Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition

Cancer Immunology, Immunotherapy

Volumn 58, Issue 5, 2009, Pages 719-728

  Moore, Tamson V ^a   Lyons, Gretchen E ^a   Brasic, Natasha ^a   Roszkowski, Jeffrey J ^a   Voelkl, Simon ^b   MacKensen, Andreas ^b   Kast, W Martin ^c,d   Le Poole, I Caroline ^e   Nishimura, Michael I ^f  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^f MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Affinity; Melanoma; T cells; TCR

Indexed keywords

CD8 ANTIGEN; GLYCOPROTEIN GP 100; HLA A2 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ARTICLE; CELL CLONE; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE FUNCTION; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; T LYMPHOCYTE; TUMOR CELL;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL LINE, TUMOR; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; GENE REARRANGEMENT, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ACTIVE; JURKAT CELLS; LYMPHOCYTES, TUMOR-INFILTRATING; MELANOMA; MEMBRANE GLYCOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 61349102416     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-008-0594-2     Document Type: Article

References (51)

1. T Boon PG Coulie B Van den Eynde 1997 Tumor antigens recognized by T cells Immunol Today 18 6 267 268
2. SA Rosenberg 1999 A new era for cancer immunotherapy based on the genes that encode cancer antigens Immunity 10 3 281 287
3. H Mizoguchi JJ O'Shea DL Longo CM Loeffler DW McVicar AC Ochoa 1992 Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice Science 258 5089 1795 1798
4. JH Finke AH Zea J Stanley DL Longo H Mizoguchi RR Tubbs RH Wiltrout JJ O'Shea S Kudoh E Klein RM Bukowski AC Ochoa 1993 Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma Cancer Res 53 23 5613 5616
5. MA Alexander-Miller GR Leggatt JA Berzofsky 1996 Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy Proc Natl Acad Sci 93 9 4102 4107
6. HJ Zeh D Perry-Lalley ME Dudley SA Rosenberg JC Yang 1999 High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy J Immunol 162 2 989 994
7. ME Dudley MI Nishimura AK Holt SA Rosenberg 1999 Antitumor immunization with a minimal peptide epitope (G9-209-2 M) leads to a functionally heterogeneous CTL response J Immunother 22 4 288 298
8. TM Clay MC Custer J Sachs P Hwu SA Rosenberg MI Nishimura 1999 Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity J Immunol 163 1 507 513
9. L Duval H Schmidt K Kaltoft K Fode JJ Jensen SM Sorensen MI Nishimura H von der Maase 2006 Adoptive transfer of allogeneic cytotoxic T lymphocytes equipped with a HLA-A2 restricted MART-1 T-cell receptor: a phase I trial in metastatic melanoma Clin Cancer Res 12 4 1229 1236
10. RA Morgan ME Dudley JR Wunderlich MS Hughes JC Yang RM Sherry RE Royal SL Topalian US Kammula NP Restifo Z Zheng A Nahvi CR de Vries LJ Rogers-Freezer SA Mavroukakis SA Rosenberg 2006 Cancer regression in patients after transfer of genetically engineered lymphocytes Science 314 5796 126 129
11. JJ Roszkowski DC Yu MP Rubinstein MD McKee DJ Cole MI Nishimura 2003 CD8 independent tumor cell recognition is a property of the T cell receptor and not the T cell J Immunol 170 5 2582 2589
12. + melanoma reactive T cells by retroviral mediated TCR gene transfer Cancer Res 65 4 1570 1576
13. GG Callender HR Rosen JJ Roszkowski GE Lyons M Li TV Moore N Brasic MD McKee MI Nishimura 2006 Identification of a CD8-independent Hepatitis C virus-specific T cell receptor that does not require CD8 for target cell recognition Hepatology 43 5 973 981
14. SL Topalian D Solomon SA Rosenberg 1989 Tumor-specific cytolysis by lymphocytes infiltrating human melanomas J Immunol 142 10 3714 3725
15. MI Nishimura Y Kawakami P Charmley B O'Neil J Shilyansky JR Yannelli SA Rosenberg L Hood 1994 T-cell receptor repertoire in tumor-infiltrating lymphocytes. Analysis of melanoma-specific long-term lines J Immunother 16 2 85 94
16. J Shilyansky MI Nishimura JR Yannelli Y Kawakami LS Jacknin P Charmley SA Rosenberg 1994 T-cell receptor usage by melanoma-specific clonal and highly oligoclonal tumor-infiltrating lymphocyte lines Proc Natl Acad Sci 91 7 2829 2833
17. J Deveraux P Haeberli O Smithies 1984 A comprehensive set of sequence analysis programs for the VAX Nucleic Acids Res 12 1 387 395
18. MD McKee JJ Roszkowski MI Nishimura 2005 T cell avidity and tumor recognition: implications and therapeutic strategies J Transl Med 3 35
19. K Kedzierska NL La Gruta MP Davenport SJ Turner PC Doherty 2005 Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses Proc Natl Acad Sci 102 32 11432 11437
20. L Trautmann M Rimbert K Echasserieau X Saulquin B Neveu J Dechanet V Cerundolo M Bonneville 2005 Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses J Immunol 175 9 6123 6132
21. M Iero P Squarcina P Romero P Guillaume E Scarselli R Cerino M Carrabba O Toutirais G Parmiani L Rivoltini 2007 Low TCR avidity and lack of tumor cell recognition in CD8(+) T cells primed with the CEA-analogue CAP1-6D peptide Cancer Immunol Immunother 56 12 1979 1991
22. M Kim HB Moon K Kim KY Lee 2006 Antigen dose governs the shaping of CTL repertoires in vitro and in vivo Int Immunol 18 3 435 444
23. ME Dudley J Wunderlich MI Nishimura D Yu JC Yang SL Topalian DJ Schwartzentruber P Hwu FM Marincola R Sherry SF Leitman SA Rosenberg 2001 Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma J Immunother 24 4 363 373
24. BF Koop L Rowen K Wang CL Kuo D Seto JA Lenstra S Howard W Shan P Deshpande L Hood 1994 The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA Genomics 19 3 478 493
25. DJ Cole DP Weil J Shilyansky M Custer Y Kawakami SA Rosenberg MI Nishimura 1995 Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen Cancer Res 55 4 748 752
26. MR Parkhurst ML Salgaller S Southwood PF Robbins A Sette SA Rosenberg Y Kawakami 1996 Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues J Immunol 157 6 2539 2548
27. Seliger B (2008) Molecular mechanisms of MHC class I abnormalities and APM components in human tumors. Cancer Immunol Immunother. [Epub ahead of print]
28. B Seliger U Ritz S Ferrone 2006 Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation Int J Cancer 118 1 129 138
29. B Ortmann J Copeman PJ Lehner B Sadasivan JA Herberg AG Grandea SR Riddell R Tampé T Spies J Trowsdale P Cresswell 1997 A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes Science 277 5330 1306 1309
30. MI Nishimura D Avichezer MC Custer CS Lee C Chen MR Parkhurst RA Diamond PF Robbins DJ Schwartzentruber SA Rosenberg 1999 MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte Cancer Res 59 24 6230 6238
31. M Theobald J Biggs D Dittmer AJ Levine LA Sherman 1995 Targeting p53 as a general tumor antigen Proc Natl Acad Sci 92 26 11993 11997
32. J Kuball FW Schmitz RH Voss EA Ferreira R Engel P Guillaume S Strand P Romero C Huber LA Sherman M Theobald 2005 Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR Immunity 22 1 117 129
33. BD Santomasso WK Roberts A Thomas T Williams NE Blachere ME Dudley AN Houghton JB Posner RB Darnell 2007 A T-cell receptor associated with naturally occurring human tumor immunity Proc Natl Acad Sci 104 48 19073 19078
34. JG van den Boorn IC Le Poole RM Luiten 2006 T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity Int Rev Immunol 25 3-4 235 258
35. MK Jenkins RH Schwartz 1987 Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo J Exp Med 165 2 302 319
36. B Beverly SM Kang MJ Lenardo RH Schwartz 1992 Reversal of in vitro T cell clonal anergy by IL-2 stimulation Int Immunol 4 6 661 671
37. SA Rosenberg P Spiess R Lafreniere 1986 A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes Science 233 4770 1318 1321
38. P Aebersold C Hyatt S Johnson K Hines L Korcak M Sanders M Lotze S Topalian J Yang SA Rosenberg 1991 Lysis of autologous melanoma cells by tumor-infiltrating lymphocytes: association with clinical response J Natl Cancer Inst 83 13 932 937
39. MA Alexander-Miller GR Leggatt A Sarin JA Berzofsky 1996 Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL J Exp Med 184 2 485 492
40. AG Cawthon H Lu MA Alexander-Miller 2001 Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression J Immunol 167 5 2577 2584
41. AG Cawthon MA Alexander-Miller 2002 Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity J Immunol 169 7 3492 3498
42. GE Lyons T Moore N Brasic M Li JJ Roszkowski MI Nishimura 2006 Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells Cancer Res 66 23 11455 11461
43. GE Lyons JJ Roszkowski S Man C Yee WM Kast MI Nishimura 2006 T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T cell receptor transduced T-cells Cancer Immunol Immunother 55 9 1142 1150
44. D Gil AG Schrum B Alarcón E Palmer 2005 T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes J Exp Med 201 4 517 522
45. WW Schamel RM Risueño S Minguet AR Ortíz B Alarcón 2006 A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex Trends Immunol 27 4 176 182
46. S Minguet M Swamy B Alarcón IF Luescher WW Schamel 2007 Full activation of the T cell receptor requires both clustering and conformational changes at CD3 Immunity 26 1 43 54
47. TR Petersen S Gülland E Bettelli V Kuchroo E Palmer BT Bäckström 2004 A chimeric T cell receptor with super-signaling properties Int Immunol 16 7 889 894
48. CJ Cohen Y Zhao Z Zheng SA Rosenberg RA Morgan 2006 Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability Cancer Res 66 17 8878 8886
49. J Kuball ML Dossett M Wolfl WY Ho RH Voss C Fowler PD Greenberg 2007 Facilitating matched pairing and expression of TCR chains introduced into human T cells Blood 109 6 2331 2338
50. CJ Cohen YF Li M El-Gamil PF Robbins SA Rosenberg RA Morgan 2007 Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond Cancer Res 67 8 3898 3903
51. RH Voss RA Willemsen J Kuball M Grabowski R Engel RS Intan P Guillaume P Romero C Huber M Theobald 2008 Molecular design of the Calphabeta interface favors specific pairing of introduced TCRalphabeta in human T cells J Immunol 180 1 391 401