Family and Genetic Association Studies of Bipolar Disorder in Children

Child and Adolescent Psychiatric Clinics of North America

Volumn 18, Issue 2, 2009, Pages 441-453

  Mick, Eric ^a   Faraone, Stephen V ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Age at onset; Bipolar disorder; Childhood; Comorbidity; Genetics

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE TRANSPORTER; SEROTONIN TRANSPORTER;

BEHAVIOR; BIPOLAR DISORDER; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CATECHOL METHYLTRANSFERASE GENE; DISEASE ASSOCIATION; DOPAMINE TRANSPORTER GENE; GAD1 GENE; GENE; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; PEDIATRICS; PHENOTYPE; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SEROTONIN TRANSPORTER GENE; SLC6A3 GENE;

BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION; GENETIC MARKERS; GLUTAMATE DECARBOXYLASE; HUMANS; PHENOTYPE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 60949091520     PISSN: 10564993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chc.2008.11.008     Document Type: Review

References (81)

1. Biederman J., Mick E., Faraone S.V., et al. A Prospective Follow-Up Study of Pediatric Bipolar Disorder in boys with attention deficit/hyperactivity disorder. J Affect Disord 82S (2004) S17-S23
2. Geller B., Williams M., Zimerman B., et al. Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. J Affect Disord 51 (1998) 81-91
3. Geller B., Craney J.L., Bolhofner K., et al. One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 158 (2001) 303-305
4. Geller B., Tillman R., Bolhofner K., et al. Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: morbid risk, age at onset, and comorbidity. Arch Gen Psychiatry 63 (2006) 1130-1138
5. Birmaher B., Axelson D., Strober M., et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 63 (2006) 175-183
6. Brotman M.A., Kassem L., Reising M.M., et al. Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry 164 (2007) 1238-1241
7. Wozniak J., Biederman J., Kiely K., et al. Mania-like symptoms suggestive of childhood onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 34 (1995) 867-876
8. Wilens T.E., Biederman J., Adamson J., et al. Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder. Biol Psychiatry 62 (2007) 129-134
9. Findling R.L., Gracious B.L., McNamara N.K., et al. Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder. Bipolar Disord 3 (2001) 202-210
10. McElroy S.L., Keck J.P.E., Pope J.H.G., et al. Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania. Am J Psychiatry 149 (1992) 1633-1644
11. Geller B., Craney J.L., Bolhofner K., et al. Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 159 (2002) 927-933
12. Geller B., Tillman R., Craney J.L., et al. Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry 61 (2004) 459-467
13. Tohen M., Zarate Jr. C.A., Hennen J., et al. The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence. Am J Psychiatry 160 (2003) 2099-2107
14. Tsuang M.T., and Faraone S.V. The Genetics of Mood Disorders (1990), Johns Hopkins University Press, Baltimore (MD)
15. Pauls D.L., Morton L.A., and Egeland J.A. Risks of affective illness among first-degree relatives of bipolar I old-order Amish probands. Arch Gen Psychiatry 49 (1992) 703-708
16. Bellivier F., Golmard J.L., Rietschel M., et al. Age at onset in bipolar I affective disorder: further evidence for three subgroups. Am J Psychiatry 160 (2003) 999-1001
17. Dwyer J.T., and DeLong G.R. A family history study of twenty probands with childhood manic-depressive illness. J Am Acad Child Adolesc Psychiatry 26 (1987) 176-180
18. Kutcher S., and Marton P. Affective disorders in first-degree relatives of adolescent onset bipolars, unipolars, and normal controls. J Am Acad Child Adolesc Psychiatry 30 (1991) 75-78
19. Neuman R.J., Geller B., Rice J.P., et al. Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands. J Am Acad Child Adolesc Psychiatry 36 (1997) 466-473
20. Strober M., Morrell W., Burroughs J., et al. A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance. J Affect Disord 15 (1988) 255-268
21. Wozniak J., Biederman J., Mundy E., et al. A pilot family study of childhood-onset mania. J Am Acad Child Adolesc Psychiatry 34 (1995) 1577-1583
22. Smoller J.W., and Finn C.T. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet 123C (2003) 48-58
23. Faraone S.V., Su J., Glatt S.J., et al. Early onset bipolar disorder: evidence for linkage to chromosome 9q34. Bipolar Disord 8 (2006) 144-151
24. Lin P.I., McInnis M.G., Potash J.B., et al. Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q. Am J Hum Genet 77 (2005) 545-555
25. Etain B., Mathieu F., Rietschel M., et al. Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. Mol Psychiatry 11 (2006) 685-694
26. Zandi P.P., Badner J.A., Steele J., et al. Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates. Mol Psychiatry 12 (2007) 630-639
27. Mick E., Biederman J., Pandina G., et al. A preliminary meta-analysis of the Child Behavior Checklist in pediatric bipolar disorder. Biol Psychiatry 53 (2003) 1021-1027
28. Althoff R.R., Rettew D.C., Faraone S.V., et al. Latent class analysis shows strong heritability of the Child Behavior Checklist-juvenile bipolar phenotype. Biol Psychiatry 60 (2006) 903-911
29. Hudziak J.J., Derks E.M., Althoff R.R., et al. The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the Conners' rating scales-revised. Am J Psychiatry 162 (2005) 1614-1620
30. Hudziak J., Althoff R.R., Rettew D.C., et al. The prevalence and genetic architecture of CBCL-juvenile bipolar disorder. Biol Psychiatry 58 (2005) 562-568
31. Volk H.E., and Todd R.D. Does the Child Behavior Checklist juvenile bipolar disorder phenotype identify bipolar disorder?. Biol Psychiatry 62 (2007) 115-120
32. Faraone S.V., Althoff R.R., Hudziak J.J., et al. The CBCL predicts DSM bipolar disorder in children: A receiver operating characteristic curve analysis. Bipolar Disord 7 (2005) 518-524
33. McGough J.J., Loo S.K., McCracken J.T., et al. CBCL Pediatric Bipolar Disorder Profile and ADHD: Comorbidity and Quantitative Trait Loci Analysis. J Am Acad Child Adolesc Psychiatry (2008)
34. Youngstrom E., Youngstrom J.K., and Starr M. Bipolar diagnoses in community mental health: Achenbach Child Behavior Checklist profiles and patterns of comorbidity. Biol Psychiatry 58 (2005) 569-575
35. Mick E., Kim J.W., Biederman J., et al. Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3). Am J Med Genet B Neuropsychiatr Genet 147B (2008) 1182-1185
36. Greenwood T.A., Alexander M., Keck P.E., et al. Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet 105 (2001) 145-151
37. Greenwood T.A., Schork N.J., Eskin E., et al. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Mol Psychiatry 11 (2006) 125-133
38. Abou Jamra R., Fuerst R., Kaneva R., et al. The first genome-wide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. Am J Hum Genet 81 (2007) 974-986
39. Geller B., and Cook E. Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity. Biol Psychiatry 45 (1999) 1230-1233
40. Geller B., and Cook Jr. E.H. Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles. Biol Psychiatry 47 (2000) 605-609
41. Geller B., Badner J.A., Tillman R., et al. Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 161 (2004) 1698-1770
42. Geller B., Tillman R., Bolhofner K., et al. GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype. J Child Adolesc Psychopharmacol 18 (2008) 25-29
43. Lesch K., Bengel D., Heils A., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1532
44. Lasky-Su J.A., Faraone S.V., Glatt S.J., et al. Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet 133B (2005) 110-115
45. Axelrod J., and Tomchick R. Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem 233 (1958) 702-705
46. Lachman H.M., Papolos D.F., Saito T., et al. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6 (1996) 243-250
47. Craddock N., Dave S., and Greening J. Association studies of bipolar disorder. Bipolar Disord 3 (2001) 284-298
48. Lachman H.M., Morrow B., Shprintzen R., et al. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Am J Med Genet 67 (1996) 468-472
49. Rylett R.J., and Williams L.R. Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS. Trends Neurosci 17 (1994) 486-490
50. Egan M.F., Kojima M., Callicott J.H., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
51. Sklar P., Gabriel S.B., McInnis M.G., et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neurotrophic factor. Mol Psychiatry 7 (2002) 579-593
52. Neves-Pereira M., Mundo E., Muglia P., et al. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71 (2002) 651-655
53. Muller D.J., de Luca V., Sicard T., et al. Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder: family-based association study. Br J Psychiatry 189 (2006) 317-323
54. Strauss J., Barr C.L., George C.J., et al. Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder. Am J Med Genet B Neuropsychiatr Genet 131 (2004) 16-19
55. Strauss J., Barr C.L., George C.J., et al. Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample. Mol Psychiatry 10 (2005) 861-867
56. Pandey G.N., Rizavi H.S., Dwivedi Y., et al. Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response. J Am Acad Child Adolesc Psychiatry 47 (2008) 1077-1085
57. Bulgin N.L., Strauss J.S., King N.A., et al. Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder. Neuromolecular Med (2008) in press
58. Madras B.K., Miller G.M., and Fischman A.J. The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res 130 (2002) 57-63
59. Madras B.K., Miller G.M., and Fischman A.J. The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry 57 (2005) 1397-1409
60. Li D., Sham P.C., Owen M.J., et al. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet (2006) 2276-2284
61. Brookes K., Mill J., Guindalini C., et al. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63 (2006) 74-81
62. Brookes K., Xu X., Chen W., et al. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 11 (2006) 934-953
63. Faraone S.V., Biederman J., Wozniak J., et al. Is comorbidity with ADHD a marker for juvenile onset mania?. J Am Acad Child Adolesc Psychiatry 36 (1997) 1046-1055
64. Faraone S.V., Biederman J., and Monuteaux M.C. Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype?. J Affect Disord 64 (2001) 19-26
65. Faraone S.V., Biederman J., Mennin D., et al. Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype?. J Am Acad Child Adolesc Psychiatry 36 (1997) 1378-1387
66. Bocchetta A., Piccardi M.P., Palmas M.A., et al. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. Am J Med Genet 88 (1999) 522-526
67. Gomez-Casero E., Perez de Castro I., Saiz-Ruiz J., et al. No association between particular DRD3 and DAT gene polymorphisms and manic-depressive illness in a Spanish sample. Psychiatr Genet 6 (1996) 209-212
68. Waldman I.D., Robinson B.F., and Feigon S.A. Linkage disequilibrium between the dopamine transporter gene (DAT1) and bipolar disorder: extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity. Genet Epidemiol 14 (1997) 699-704
69. Stober G., Sprandel J., Schmidt F., et al. Association study of 5'-UTR polymorphisms of the human dopamine transporter gene with manic depression. Bipolar Disord 8 (2006) 490-495
70. Erlander M.G., Tillakaratne N.J., Feldblum S., et al. Two genes encode distinct glutamate decarboxylases. Neuron 7 (1991) 91-100
71. Bu D.F., and Tobin A.J. The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD. Genomics 21 (1994) 222-228
72. Addington A.M., Gornick M., Duckworth J., et al. GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss. Mol Psychiatry 10 (2005) 581-588
73. WTCCC TWTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
74. Baum A.E., Akula N., Cabanero M., et al. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13 (2008) 197-207
75. Sklar P., Smoller J.W., Fan J., et al. Whole-genome association study of bipolar disorder. Mol Psychiatry 13 (2008) 558-569
76. Baum A.E., Hamshere M., Green E., et al. Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement. Mol Psychiatry 13 (2008) 466-467
77. Ferreira M.A., O'Donovan M.C., Meng Y.A., et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40 (2008) 1056-1058
78. Carlson G.A., Jensen P.S., Findling R.L., et al. Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference. J Child Adolesc Psychopharmacol 13 (2003) 13-27
79. Tohen M., Kryzhanovskaya L., Carlson G., et al. Olanzapine versus placebo in the treatment of adolescents with bipolar mania. Am J Psychiatry 164 (2007) 1547-1556
80. Pandina GJ, Delbello M, Kushner S, et al: Risperidone for the treatment of acute mania in bipolar youth. In 54th Annual Meeting of the American Academy of Child and Adolescent Psychiatry, Boston (MA): 2007. p. 246.
81. Forbes A, Chang KD, Nyilas M, et al: Acute efficacy and tolerability of aripiprazole for the treatment of bipolar-I disorder in pediatric patients. In 161st Annual Meeting of the American Psychiatric Association, Washington, DC; 2008. p. 296-7.