메뉴 건너뛰기




Volumn 9, Issue 3, 1999, Pages 150-172

Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures: Are renal cells in tissue culture hypoxic?

Author keywords

Glutaminase; Glycolysis; Glycolytic enzymes; LLC PK 1 cells; OK cells; Oxygenation

Indexed keywords

6 PHOSPHOFRUCTOKINASE; GLUCOSE; GLYCOLYTIC ENZYME; HEXOKINASE; LACTATE DEHYDROGENASE; PYRUVATE KINASE;

EID: 0032859002     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016312     Document Type: Article
Times cited : (86)

References (99)
  • 1
    • 0020022709 scopus 로고
    • Structure function correlation on rat kidney. Quantitative correlation of structure and function in the normal and injured rat kidney
    • Pfaller W: Structure function correlation on rat kidney. Quantitative correlation of structure and function in the normal and injured rat kidney. Adv Anat Embryol Cell Biol 1982;70:1-106.
    • (1982) Adv Anat Embryol Cell Biol , vol.70 , pp. 1-106
    • Pfaller, W.1
  • 2
    • 0021619876 scopus 로고
    • Enzyme distribution along the nephron
    • Guder WG, Ross BD: Enzyme distribution along the nephron. Kidney Int 1984;26:101-111.
    • (1984) Kidney int , vol.26 , pp. 101-111
    • Guder, W.G.1    Ross, B.D.2
  • 3
    • 0021961195 scopus 로고
    • Interrelation between oxygen consumption an Na-K-ATPase activity in rat renal proximal tubule suspension
    • Gstraunthaler G, Pfaller W, Kotanko P: Interrelation between oxygen consumption an Na-K-ATPase activity in rat renal proximal tubule suspension. Renal Physiol 1985;8: 38-44.
    • (1985) Renal Physiol , vol.8 , pp. 38-44
    • Gstraunthaler, G.1    Pfaller, W.2    Kotanko, P.3
  • 4
    • 0017107851 scopus 로고
    • Substrate and oxygen dependence of renal metabolism
    • Guder WG, Schmidt U: Substrate and oxygen dependence of renal metabolism. Kidney Int 1976;10:S32-S38.
    • (1976) Kidney int , vol.10
    • Guder, W.G.1    Schmidt, U.2
  • 5
  • 6
    • 0025001336 scopus 로고
    • Biochemical pathways and modulators of renal ammoniagenesis
    • Tannen RL, Sahai A: Biochemical pathways and modulators of renal ammoniagenesis. Miner Electrolyte Metab 1990;16:249-258.
    • (1990) Miner Electrolyte Metab , vol.16 , pp. 249-258
    • Tannen, R.L.1    Sahai, A.2
  • 7
    • 0028189209 scopus 로고
    • Ammoniagenesis in renal cell culture. a comparative study on ammonia metabolism of renal epithelial cell lines
    • Basel, Karger
    • Gstraunthaler GJA: Ammoniagenesis in renal cell culture. A comparative study on ammonia metabolism of renal epithelial cell lines. Contrib Nephrol. Basel, Karger, 1994, vol 110, pp 88-97.
    • (1994) Contrib Nephrol. , vol.110 , pp. 88-97
    • Gstraunthaler, G.J.A.1
  • 9
    • 0026002432 scopus 로고
    • Regulation of renal ammoniagenesis in metabolic acidosis
    • Schoolwerth AC: Regulation of renal ammoniagenesis in metabolic acidosis. Kidney Int 1991;40:961-973.
    • (1991) Kidney int , vol.40 , pp. 961-973
    • Schoolwerth, A.C.1
  • 12
    • 0345723739 scopus 로고
    • The use of cultured renal epithelial cells in in vitro assessment of xenobiotic-induced nephrotoxicity
    • Anders MW, Dekant W, Henschler D, Oberleithner H, Silbernagl S (eds): San Diego, Academic Press
    • Gstraunthaler G, Pfaller W: The use of cultured renal epithelial cells in in vitro assessment of xenobiotic-induced nephrotoxicity; in Anders MW, Dekant W, Henschler D, Oberleithner H, Silbernagl S (eds): Renal Disposition and Nephrotoxicity of Xenobiotics. San Diego, Academic Press, 1993, pp 27-61.
    • (1993) Renal Disposition and Nephrotoxicity of Xenobiotics , pp. 27-61
    • Gstraunthaler, G.1    Pfaller, W.2
  • 13
    • 0025113468 scopus 로고
    • Renal cell cultures: A tool for studying tubular function and nephrotoxicity
    • Gstraunthaler G, Steinmassl D, Pfaller W: Renal cell cultures: A tool for studying tubular function and nephrotoxicity. Toxicol Lett 1990; 53:1-7.
    • (1990) Toxicol Lett , vol.53 , pp. 1-7
    • Gstraunthaler, G.1    Steinmassl, D.2    Pfaller, W.3
  • 14
    • 0010619536 scopus 로고
    • Energy metabolism of cellular activation, growth, and transformation
    • Mandel LJ: Energy metabolism of cellular activation, growth, and transformation. Curr Top Membr Transport 1986;27:261-291.
    • (1986) Curr Top Membr Transport , vol.27 , pp. 261-291
    • Mandel, L.J.1
  • 15
    • 0026609312 scopus 로고
    • Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells
    • Aleo MD, Schnellmann RG: Regulation of glycolytic metabolism during long-term primary culture of renal proximal tubule cells. Am J Physiol 1992;262:F77-F85.
    • (1992) Am J Physiol , vol.262
    • Aleo, M.D.1    Schnellmann, R.G.2
  • 16
    • 0030666980 scopus 로고    scopus 로고
    • Glycolysis inhibition by palmitate in renal cells cultured in a two-chamber system
    • Bolon C, Gauthier C, Simonnet H: Glycolysis inhibition by palmitate in renal cells cultured in a two-chamber system. Am J Physiol 1997;273:C1732-C1738.
    • (1997) Am J Physiol , vol.273
    • Bolon, C.1    Gauthier, C.2    Simonnet, H.3
  • 17
    • 0026332898 scopus 로고
    • Morphological an biochemical characterization of the opossum kidney cell line and primary cultures of rabbit proximal tubule cells in serum-free defined medium
    • Courjault F, Gerin B, Leroy D, Chevalier J, Toutain H: Morphological an biochemical characterization of the opossum kidney cell line and primary cultures of rabbit proximal tubule cells in serum-free defined medium. Cell Biol Int Rep 1991;15: 1225-1234.
    • (1991) Cell Biol int Rep , vol.15 , pp. 1225-1234
    • Courjault, F.1    Gerin, B.2    Leroy, D.3    Chevalier, J.4    Toutain, H.5
  • 18
    • 0027232649 scopus 로고
    • Effect of glucose and insulin deprivation on differentiation and carbohydrate metabolism of rabbit proximal tubular cells in primary culture
    • Courjault F, Chevalier J, Leroy D, Toutain H: Effect of glucose and insulin deprivation on differentiation and carbohydrate metabolism of rabbit proximal tubular cells in primary culture. Biochim Biophys Acta 1993;1177:147-159.
    • (1993) Biochim Biophys Acta , vol.1177 , pp. 147-159
    • Courjault, F.1    Chevalier, J.2    Leroy, D.3    Toutain, H.4
  • 19
    • 84939691083 scopus 로고
    • Insulin and glucose impact on functional and morphological differentiation of rabbit proximal tubule cells in primary culture
    • Monteil C, Leclere C, Fillastre JP, Morin JP: Insulin and glucose impact on functional and morphological differentiation of rabbit proximal tubule cells in primary culture. Renal Physiol Biochem 1993;16: 212-221.
    • (1993) Renal Physiol Biochem , vol.16 , pp. 212-221
    • Monteil, C.1    Leclere, C.2    Fillastre, J.P.3    Morin, J.P.4
  • 20
    • 0028927094 scopus 로고
    • Expression and subcellular distribution of phosphoenolpyruvate carboxykinase in primary cultures of rabbit kidney proximal tubule cells: Comparative study with renal and hepatic PEPCK in vivo
    • Monteil C, Fillastre JP, Morin JP: Expression and subcellular distribution of phosphoenolpyruvate carboxykinase in primary cultures of rabbit kidney proximal tubule cells: Comparative study with renal and hepatic PEPCK in vivo. Biochim Biophys Acta 1995;1243:437-445.
    • (1995) Biochim Biophys Acta , vol.1243 , pp. 437-445
    • Monteil, C.1    Fillastre, J.P.2    Morin, J.P.3
  • 21
    • 0028913368 scopus 로고
    • Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells
    • Nowak G, Schnellmann RG: Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells. Am J Physiol 1995;268:C1053-C1061.
    • (1995) Am J Physiol , vol.268
    • Nowak, G.1    Schnellmann, R.G.2
  • 22
    • 0025080227 scopus 로고
    • Relationship between proliferation and glucose metabolism in primary cultures of rabbit proximal tubules
    • Tang MJ, Tannen RL: Relationship between proliferation and glucose metabolism in primary cultures of rabbit proximal tubules. Am J Physiol 1990;259;C455-C461.
    • (1990) Am J Physiol , vol.259
    • Tang, M.J.1    Tannen, R.L.2
  • 23
    • 0024597865 scopus 로고
    • Carbohydrate metabolism by primary cultures of rabbit proximal tubules
    • Tang MJ, Suresh KR, Tannen RL: Carbohydrate metabolism by primary cultures of rabbit proximal tubules. Am J Physiol 1989;256: C532-C539.
    • (1989) Am J Physiol , vol.256
    • Tang, M.J.1    Suresh, K.R.2    Tannen, R.L.3
  • 24
    • 0026163057 scopus 로고
    • Biochemical, functional, and morphological characterization of a primary culture of rabbit proximal tubule cells
    • Toutain H, Vauclin-Jaques N, Fillastre JP, Morin JP: Biochemical, functional, and morphological characterization of a primary culture of rabbit proximal tubule cells. Exp Cell Res 1991;194:9-18.
    • (1991) Exp Cell Res , vol.194 , pp. 9-18
    • Toutain, H.1    Vauclin-Jaques, N.2    Fillastre, J.P.3    Morin, J.P.4
  • 25
    • 0025829198 scopus 로고
    • Conversion of a rabbit proximal convoluted tubule (PCT) into a cell monolayer: Ultrastructural study of cell dedifferentiation and redifferentiation
    • Koechlin M, Pisam M, Poujeol P, Taue M, Rambourg A: Conversion of a rabbit proximal convoluted tubule (PCT) into a cell monolayer: Ultrastructural study of cell dedifferentiation and redifferentiation. Eur J Cell Biol 1991;54:224-236.
    • (1991) Eur J Cell Biol , vol.54 , pp. 224-236
    • Koechlin, M.1    Pisam, M.2    Poujeol, P.3    Taue, M.4    Rambourg, A.5
  • 28
    • 0027441056 scopus 로고
    • Selective release of apical membrane enzymes from cultured renal epithelial by phosphatidylinositol-specific phospholipase C
    • Netzer A, Gstraunthaler G: Selective release of apical membrane enzymes from cultured renal epithelial by phosphatidylinositol-specific phospholipase C. Renal Physiol Biochem 1993;16:299-310.
    • (1993) Renal Physiol Biochem , vol.16 , pp. 299-310
    • Netzer, A.1    Gstraunthaler, G.2
  • 30
    • 0026631762 scopus 로고
    • Increased functional differentiation of rabbit proximal tubule cells cultured in glucose-free media
    • Blais A, Jalal F, Crine P, Paiement J, Berteloot A: Increased functional differentiation of rabbit proximal tubule cells cultured in glucose-free media. Am J Physiol 1992;263: F152-F162.
    • (1992) Am J Physiol , vol.263
    • Blais, A.1    Jalal, F.2    Crine, P.3    Paiement, J.4    Berteloot, A.5
  • 31
    • 0029034922 scopus 로고
    • Consecutive use of hormonally defined serum-free media to establish highly differentiated human renal proximal tubule cells in primary culture
    • Courjault-Gautier F, Chevalier J, Abbou CC, Chopin K, Toutain HJ: Consecutive use of hormonally defined serum-free media to establish highly differentiated human renal proximal tubule cells in primary culture. J Am Soc Nephrol 1995;5: 1949-1963.
    • (1995) J Am Soc Nephrol , vol.5 , pp. 1949-1963
    • Courjault-Gautier, F.1    Chevalier, J.2    Abbou, C.C.3    Chopin, K.4    Toutain, H.J.5
  • 32
    • 0026502481 scopus 로고
    • Growth and function of primary rabbit kidney proximal tubule cells in glucose-free serum-free medium
    • Jung JC, Lee SM, Kadakia N, Taub M: Growth and function of primary rabbit kidney proximal tubule cells in glucose-free serum-free medium. J Cell Physiol 1992;150:243-250.
    • (1992) J Cell Physiol , vol.150 , pp. 243-250
    • Jung, J.C.1    Lee, S.M.2    Kadakia, N.3    Taub, M.4
  • 33
    • 0025911623 scopus 로고
    • Insulin and other regulatory factors modulate the growth and the phosphoenolpyruvate carboxykinase (PEPCK) activity of primary rabbit kidney proximal tubule cells in serum-free medium
    • Wang Y, Taub M: Insulin and other regulatory factors modulate the growth and the phosphoenolpyruvate carboxykinase (PEPCK) activity of primary rabbit kidney proximal tubule cells in serum-free medium. J Cell Physiol 1991;147:374-382.
    • (1991) J Cell Physiol , vol.147 , pp. 374-382
    • Wang, Y.1    Taub, M.2
  • 34
    • 0028291777 scopus 로고
    • Decreasing glycolysis increases sensitivity to mitochondrial inhibition in primary cultures of renal proximal tubule cells
    • Griner RD, Schnellmann RG: Decreasing glycolysis increases sensitivity to mitochondrial inhibition in primary cultures of renal proximal tubule cells. In Vitro Cell Dev Biol 1994;30A:30-34.
    • (1994) In Vitro Cell Dev Biol , vol.30 A , pp. 30-34
    • Griner, R.D.1    Schnellmann, R.G.2
  • 35
    • 0027517628 scopus 로고
    • Modulation of glycolysis induction in primary cultures of rabbit kidney proximal tubule cells: The role of shaking, glucose and insulin
    • Monteil C, Leclere C, Dantzer F, Elkaz V, Fillastre JP, Morin JP: Modulation of glycolysis induction in primary cultures of rabbit kidney proximal tubule cells: The role of shaking, glucose and insulin. Cell Biol Int Rep 1993;17:953-960.
    • (1993) Cell Biol int Rep , vol.17 , pp. 953-960
    • Monteil, C.1    Leclere, C.2    Dantzer, F.3    Elkaz, V.4    Fillastre, J.P.5    Morin, J.P.6
  • 37
    • 0023105578 scopus 로고
    • Isolation, growth, and characterization of a gluconeogenic strain of renal cells
    • Gstraunthaler G, Handler JS: Isolation, growth, and characterization of a gluconeogenic strain of renal cells. Am J Physiol 1987;252:C232-C238.
    • (1987) Am J Physiol , vol.252
    • Gstraunthaler, G.1    Handler, J.S.2
  • 40
    • 0028938894 scopus 로고
    • Subcellular localization of PEPCK and metabolism of gluconeogenic substrains of renal cell lines
    • Holcomb T. Curthoys NP, Gstraunthaler G: Subcellular localization of PEPCK and metabolism of gluconeogenic substrains of renal cell lines. Am J Physiol 1995;268:C449-C457.
    • (1995) Am J Physiol , vol.268
    • Holcomb, T.1    Curthoys, N.P.2    Gstraunthaler, G.3
  • 41
    • 0001854884 scopus 로고
    • Basic cell culture techniques and the maintenance of cell lines
    • Davis JM (ed): Oxford, IRL Press
    • McAteer JA, Davis J: Basic cell culture techniques and the maintenance of cell lines; in Davis JM (ed): Basic Cell Culture. A Practical Approach. Oxford, IRL Press, 1994, pp 93-148.
    • (1994) Basic Cell Culture. A Practical Approach , pp. 93-148
    • McAteer, J.A.1    Davis, J.2
  • 42
    • 0344860807 scopus 로고
    • Processes with animal cell and tissue cultures
    • Rehm HJ, Reed G (eds): Weinheim, Verlag Chemie VCH
    • Butler M: Processes with animal cell and tissue cultures; in Rehm HJ, Reed G (eds): Biotechnology. Weinheim, Verlag Chemie VCH, 1988, vol 6b, pp 249-316.
    • (1988) Biotechnology , vol.6 B , pp. 249-316
    • Butler, M.1
  • 43
    • 0024764155 scopus 로고
    • Nutritional aspects of the growth of animal cells in culture
    • Butler M, Jenkins H: Nutritional aspects of the growth of animal cells in culture. J Biotechnol 1989;12:97-110.
    • (1989) J Biotechnol , vol.12 , pp. 97-110
    • Butler, M.1    Jenkins, H.2
  • 44
    • 0023483203 scopus 로고
    • Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture
    • Miller WM, Wilke CR, Blanch HW: Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J Cell Physiol 1987;132:524-530.
    • (1987) J Cell Physiol , vol.132 , pp. 524-530
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 45
    • 0024462705 scopus 로고
    • Growth of mammalian cells at high oxygen concentrations
    • Oller AR, Buser CW, Tyo MA, Thilly WG: Growth of mammalian cells at high oxygen concentrations. J Cell Sci 1989;94:43-49.
    • (1989) J Cell Sci , vol.94 , pp. 43-49
    • Oller, A.R.1    Buser, C.W.2    Tyo, M.A.3    Thilly, W.G.4
  • 46
    • 0030049769 scopus 로고    scopus 로고
    • Comparative analysis of glucose and glutamine metabolism in transformed cell lines, insect and primary liver cells
    • Neermann J, Wagner R: Comparative analysis of glucose and glutamine metabolism in transformed cell lines, insect and primary liver cells. J Cell Physiol 1996;166:152-169.
    • (1996) J Cell Physiol , vol.166 , pp. 152-169
    • Neermann, J.1    Wagner, R.2
  • 47
    • 0028189966 scopus 로고
    • pH and hormonal regulation of ammoniagenesis in cultured OK cells
    • Basel, Karger
    • Nissim I, States B, Nissim I, Lin ZP, Yudkoff M: pH and hormonal regulation of ammoniagenesis in cultured OK cells. Contrib Nephrol. Basel, Karger, 1994, vol 110, pp 30-40.
    • (1994) Contrib Nephrol. , vol.110 , pp. 30-40
    • Nissim, I.1    States, B.2    Nissim, I.3    Lin, Z.P.4    Yudkoff, M.5
  • 48
    • 0029099953 scopus 로고
    • Regulation of glutaminase activity and glutamine metabolism
    • Curthoys NP, Watford M: Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr 1995;15:133-159.
    • (1995) Annu Rev Nutr , vol.15 , pp. 133-159
    • Curthoys, N.P.1    Watford, M.2
  • 49
    • 0023763120 scopus 로고
    • Catabolic control of mammalian cell culture
    • Glacken MW: Catabolic control of mammalian cell culture. Biotechnology 1988;6:1041-1050.
    • (1988) Biotechnology , vol.6 , pp. 1041-1050
    • Glacken, M.W.1
  • 50
    • 0023664719 scopus 로고
    • End products of glucose and glutamine metabolism by L929 cells
    • Lanks KW: End products of glucose and glutamine metabolism by L929 cells. J Biol Chem 1987;262:10093-10097.
    • (1987) J Biol Chem , vol.262 , pp. 10093-10097
    • Lanks, K.W.1
  • 51
    • 0023880944 scopus 로고
    • End products of glucose and glutamine metabolism by cultured cell lines
    • Lanks KW, Li PW: End products of glucose and glutamine metabolism by cultured cell lines. J Cell Physiol 1988;135:151-155.
    • (1988) J Cell Physiol , vol.135 , pp. 151-155
    • Lanks, K.W.1    Li, P.W.2
  • 52
    • 0019898583 scopus 로고
    • Glycolysis, glutaminolysis and cell proliferation
    • McKeehan WL: Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 1982;6:635-650.
    • (1982) Cell Biol int Rep , vol.6 , pp. 635-650
    • McKeehan, W.L.1
  • 53
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
    • Reitzer LJ, Wice BM, Kennell D: Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 1979; 254:2669-2676.
    • (1979) J Biol Chem , vol.254 , pp. 2669-2676
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 54
    • 0021366190 scopus 로고
    • Glutamine: A major energy source for cultured mammalian cells
    • Zielke HR, Zielke CL, Ozand PT: Glutamine: A major energy source for cultured mammalian cells. Fed Proc 1984;43:121-125.
    • (1984) Fed Proc , vol.43 , pp. 121-125
    • Zielke, H.R.1    Zielke, C.L.2    Ozand, P.T.3
  • 55
    • 0024459845 scopus 로고
    • Primary cultures of rabbit renal proximal tubule cells. I. Growth and biochemical characteristics
    • Aleo MD, Taub ML, Nickerson PA, Kostyniak PJ: Primary cultures of rabbit renal proximal tubule cells. I. Growth and biochemical characteristics. In Vitro Cell Dev Biol 1989;25:776-783.
    • (1989) In Vitro Cell Dev Biol , vol.25 , pp. 776-783
    • Aleo, M.D.1    Taub, M.L.2    Nickerson, P.A.3    Kostyniak, P.J.4
  • 56
    • 0021686472 scopus 로고
    • Primary culture, cellular stress and differentiated function
    • Wolffe AP, Tata JR: Primary culture, cellular stress and differentiated function. FEBS Lett 1984; 176:8-15.
    • (1984) FEBS Lett , vol.176 , pp. 8-15
    • Wolffe, A.P.1    Tata, J.R.2
  • 57
    • 0024999067 scopus 로고
    • Activation of the heat shock transcription factor by hypoxia in mammalian cells
    • Benjamin IJ, Kröger B, Williams RS: Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proc Natl Acad Sci USA 1990;87:6263-6267.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6263-6267
    • Benjamin, I.J.1    Kröger, B.2    Williams, R.S.3
  • 58
    • 0027522356 scopus 로고
    • Cells in stress: Transcriptional activation of heat shock genes
    • Morimoto RI: Cells in stress: Transcriptional activation of heat shock genes. Science 1993;259:1409-1410.
    • (1993) Science , vol.259 , pp. 1409-1410
    • Morimoto, R.I.1
  • 59
    • 0021133350 scopus 로고
    • Culture shock. Synthesis of heat-shock-like proteins in fresh primary cell cultures
    • Wolffe AP, Glover JF, Tata JR: Culture shock. Synthesis of heat-shock-like proteins in fresh primary cell cultures. Exp Cell Res 1984;154: 581-590.
    • (1984) Exp Cell Res , vol.154 , pp. 581-590
    • Wolffe, A.P.1    Glover, J.F.2    Tata, J.R.3
  • 61
    • 33745425733 scopus 로고    scopus 로고
    • 1 cell proliferation and dedifferentiation by the activation of protein kinase C
    • 1 cell proliferation and dedifferentiation by the activation of protein kinase C. Am J Physiol 1997; 272:F809-F815.
    • (1997) Am J Physiol , vol.272
    • Sahai, A.1    Mei, C.2    Zavosh, A.3    Tannen, R.L.4
  • 62
    • 0028077867 scopus 로고
    • Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization
    • Petch D, Butler M: Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization. J Cell Physiol 1994;161:71-76.
    • (1994) J Cell Physiol , vol.161 , pp. 71-76
    • Petch, D.1    Butler, M.2
  • 64
    • 0019849530 scopus 로고
    • The continuous growth of vertebrate cells in the absence of sugar
    • Wice BM, Reitzer LJ, Kennell D: The continuous growth of vertebrate cells in the absence of sugar. J Biol Chem 1981;256:7812-7819.
    • (1981) J Biol Chem , vol.256 , pp. 7812-7819
    • Wice, B.M.1    Reitzer, L.J.2    Kennell, D.3
  • 65
    • 0000045991 scopus 로고
    • The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid
    • Eagle H, Oyama VI, Levy M, Horton CL, Fleischman R: The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid. J Biol Chem 1956; 218:607-617.
    • (1956) J Biol Chem , vol.218 , pp. 607-617
    • Eagle, H.1    Oyama, V.I.2    Levy, M.3    Horton, C.L.4    Fleischman, R.5
  • 66
    • 0027480269 scopus 로고
    • Uptake of glutamate, hot glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium
    • McDermott RH, Butler M: Uptake of glutamate, hot glutamine synthetase, regulates adaptation of mammalian cells to glutamine-free medium. J Cell Sci 1993;104:51-58.
    • (1993) J Cell Sci , vol.104 , pp. 51-58
    • McDermott, R.H.1    Butler, M.2
  • 67
    • 0028901229 scopus 로고
    • Growth of cultured rabbit renal tubular cells does not require exogenous glutamine
    • Bolon C, Chauvin MF, Simonnet H, Gauthier C, Baverel G: Growth of cultured rabbit renal tubular cells does not require exogenous glutamine. Kidney Int 1995;47:299-305.
    • (1995) Kidney int , vol.47 , pp. 299-305
    • Bolon, C.1    Chauvin, M.F.2    Simonnet, H.3    Gauthier, C.4    Baverel, G.5
  • 68
    • 0025340874 scopus 로고
    • Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures
    • Hassell T, Butler M: Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures. J Cell Sci 1990;96:501-508.
    • (1990) J Cell Sci , vol.96 , pp. 501-508
    • Hassell, T.1    Butler, M.2
  • 69
    • 0019332614 scopus 로고
    • The pentose cycle. Control and essential function in HeLa cell nucleic acid synthesis
    • Reitzer LJ, Wice BM, Kennell D: The pentose cycle. Control and essential function in HeLa cell nucleic acid synthesis. J Biol Chem 1980; 255:5616-5626.
    • (1980) J Biol Chem , vol.255 , pp. 5616-5626
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 70
    • 0018257869 scopus 로고
    • Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts
    • Zielke HR, Ozand PT, Tildon JT, Sevdalian DA, Cornblath M: Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts. J Cell Physiol 1978;95:41-48.
    • (1978) J Cell Physiol , vol.95 , pp. 41-48
    • Zielke, H.R.1    Ozand, P.T.2    Tildon, J.T.3    Sevdalian, D.A.4    Cornblath, M.5
  • 72
    • 0020478745 scopus 로고
    • Ribose-1-P is the essential precursor for nucleic acid synthesis in animal cells growing on uridine in the absence of sugar
    • Wice BM, Kennell D: Ribose-1-P is the essential precursor for nucleic acid synthesis in animal cells growing on uridine in the absence of sugar. J Biol Chem 1982;257:2578-2583.
    • (1982) J Biol Chem , vol.257 , pp. 2578-2583
    • Wice, B.M.1    Kennell, D.2
  • 73
    • 0021066377 scopus 로고
    • Sugar-free growth of mammalian cells on some ribonucleosides but not on others
    • Wice BM, Kennell D: Sugar-free growth of mammalian cells on some ribonucleosides but not on others. J Biol Chem 1983;258:13134-13140.
    • (1983) J Biol Chem , vol.258 , pp. 13134-13140
    • Wice, B.M.1    Kennell, D.2
  • 75
    • 0028158283 scopus 로고
    • Transcriptional control of metabolic regulation genes by carbohydrates
    • Vaulont S, Kahn A: Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J 1994;8:28-35.
    • (1994) FASEB J , vol.8 , pp. 28-35
    • Vaulont, S.1    Kahn, A.2
  • 77
    • 0019319464 scopus 로고
    • Regulation of cellular energy metabolism. the Crabtree effect
    • Sussman I, Erecinska M, Wilson DF: Regulation of cellular energy metabolism. The Crabtree effect. Biochim Biophys Acta 1980;591: 209-223.
    • (1980) Biochim Biophys Acta , vol.591 , pp. 209-223
    • Sussman, I.1    Erecinska, M.2    Wilson, D.F.3
  • 78
    • 0020695614 scopus 로고
    • Transepithelial transport in cell culture: Bioenergetics of Na-,D-glucose-coupled transport
    • Sanders MJ, Simon LM, Misfeldt DS: Transepithelial transport in cell culture: Bioenergetics of Na-,D-glucose-coupled transport. J Cell Physiol 1983;114:263-266.
    • (1983) J Cell Physiol , vol.114 , pp. 263-266
    • Sanders, M.J.1    Simon, L.M.2    Misfeldt, D.S.3
  • 79
    • 0021013570 scopus 로고
    • Regulation of sodium-coupled glucose transport by glucose in a cultured epithelium
    • Moran A, Turner RJ, Handler JS: Regulation of sodium-coupled glucose transport by glucose in a cultured epithelium. J Biol Chem 1983; 258:15087-15090.
    • (1983) J Biol Chem , vol.258 , pp. 15087-15090
    • Moran, A.1    Turner, R.J.2    Handler, J.S.3
  • 83
    • 0028180793 scopus 로고
    • High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures
    • Kreisberg JI, Radnik RA, Ayo SH, Garoni JA, Saikumar P: High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures. Kidney Int 1994;46: 105-112.
    • (1994) Kidney int , vol.46 , pp. 105-112
    • Kreisberg, J.I.1    Radnik, R.A.2    Ayo, S.H.3    Garoni, J.A.4    Saikumar, P.5
  • 85
    • 0028785437 scopus 로고
    • Integrative effects of EFG on metabolism and proliferation in renal proximal tubular cells
    • Nowak G, Schnellmann RG: Integrative effects of EFG on metabolism and proliferation in renal proximal tubular cells. Am J Physiol 1995;269:C1317-C1325.
    • (1995) Am J Physiol , vol.269
    • Nowak, G.1    Schnellmann, R.G.2
  • 86
    • 0022559184 scopus 로고
    • Renal metabolism during normoxia, hypoxia, and ischemic injury
    • Jones DP: Renal metabolism during normoxia, hypoxia, and ischemic injury. Annu Rev Physiol 1986;48:33-50.
    • (1986) Annu Rev Physiol , vol.48 , pp. 33-50
    • Jones, D.P.1
  • 88
    • 0001875002 scopus 로고
    • When is a mammalian cell hypoxic? Insights from studies of cells versus mitochondria
    • Jones DP, Kennedy FG, Andersson BS, Aw TY, Wilson E: When is a mammalian cell hypoxic? Insights from studies of cells versus mitochondria. Mol Physiol 1985;8:473-482.
    • (1985) Mol Physiol , vol.8 , pp. 473-482
    • Jones, D.P.1    Kennedy, F.G.2    Andersson, B.S.3    Aw, T.Y.4    Wilson, E.5
  • 90
    • 0002498741 scopus 로고
    • Scaling-up of animal cell cultures
    • Freshney RI (ed): Oxford, IRL Press
    • Griffiths B: Scaling-up of animal cell cultures; in Freshney RI (ed): Animal Cell Culture. A Practical Approach. Oxford, IRL Press, 1986, pp 33-69.
    • (1986) Animal Cell Culture. A Practical Approach , pp. 33-69
    • Griffiths, B.1
  • 92
    • 0027362262 scopus 로고
    • 2 in erythropoietin-producing human hepatoma cell cultures
    • 2 in erythropoietin-producing human hepatoma cell cultures. Am J Physiol 1993;265: C1266-C1270.
    • (1993) Am J Physiol , vol.265
    • Wolff, M.1    Fandrey, J.2    Jelkmann, W.3
  • 93
    • 0021345887 scopus 로고
    • Coordinate regulation of glycolysis by hypoxia in mammalian cells
    • Robin ED, Murphy BJ, Theodore J: Coordinate regulation of glycolysis by hypoxia in mammalian cells. J Cell Physiol 1984;118:287-290.
    • (1984) J Cell Physiol , vol.118 , pp. 287-290
    • Robin, E.D.1    Murphy, B.J.2    Theodore, J.3
  • 94
    • 0021349488 scopus 로고
    • Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells
    • Murphy BJ, Robin ED, Tapper DP, Wong RJ, Clayton DA: Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells. Science 1984;223:707-709.
    • (1984) Science , vol.223 , pp. 707-709
    • Murphy, B.J.1    Robin, E.D.2    Tapper, D.P.3    Wong, R.J.4    Clayton, D.A.5
  • 95
    • 0019506518 scopus 로고
    • Differences in oxygen-dependent regulation of enzymes between tumor and normal cell systems in culture
    • Simon LM, Robin ED, Theodore J: Differences in oxygen-dependent regulation of enzymes between tumor and normal cell systems in culture. J Cell Physiol 1981;108:393-400.
    • (1981) J Cell Physiol , vol.108 , pp. 393-400
    • Simon, L.M.1    Robin, E.D.2    Theodore, J.3
  • 96
    • 0020052491 scopus 로고
    • Modulation of epithelial cell proliferation in culture by dissolved oxygen
    • Taylor WG, Camalier RF: Modulation of epithelial cell proliferation in culture by dissolved oxygen. J Cell Physiol 1982;111:21-27.
    • (1982) J Cell Physiol , vol.111 , pp. 21-27
    • Taylor, W.G.1    Camalier, R.F.2
  • 97
    • 0026799250 scopus 로고
    • Relationship between culture conditions and the dependency on mitochondrial function of mammalian cell proliferation
    • Van den Bogert C, Spelbrink JN, Dekker HL: Relationship between culture conditions and the dependency on mitochondrial function of mammalian cell proliferation. J Cell Physiol 1992;152:632-638.
    • (1992) J Cell Physiol , vol.152 , pp. 632-638
    • Van Den Bogert, C.1    Spelbrink, J.N.2    Dekker, H.L.3
  • 98
    • 0029756791 scopus 로고    scopus 로고
    • Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism
    • Rajpurohit R, Koch CJ, Tao Z, Teixeira CA, Shapiro IM: Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism. J Cell Physiol 1996;168:424-432.
    • (1996) J Cell Physiol , vol.168 , pp. 424-432
    • Rajpurohit, R.1    Koch, C.J.2    Tao, Z.3    Teixeira, C.A.4    Shapiro, I.M.5
  • 99
    • 0022629768 scopus 로고
    • Innovative approaches for the study of cultured renal epithelia
    • Valentich JD: Innovative approaches for the study of cultured renal epithelia. Miner Electrolyte Metab 1986:12:6-13.
    • (1986) Miner Electrolyte Metab , vol.12 , pp. 6-13
    • Valentich, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.