Mutation and expression of the p27(KIP1) and p57(KIP2) genes in human gastric cancer

Experimental and Molecular Medicine

Volumn 32, Issue 2, 2000, Pages 79-83

  Shin, Jong Yeon ^a   Kim, Hyun Seok ^a   Lee, Kyung Suk ^a   Kim, Jaebong ^a   Park, Jae Bong ^a   Won, Moo Ho ^a   Chae, Seung Wan ^a   Choi, Young Hee ^a   Choi, Kyung Chan ^a   Park, Young Euy ^a   Lee, Jae Yong ^a  

^a Hallym University   (South Korea)

Author keywords

CDKI; Gastric cancer; p27; p57; PCR SSCP

Indexed keywords

ALANINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; PROLINE; PROTEIN P27; PROTEIN P57; UNCLASSIFIED DRUG; CDKN1C PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DNA; ENZYME INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; NUCLEAR PROTEIN; RNA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; POLYMERASE CHAIN REACTION; RNA ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CANCER; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR;

CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASE INHIBITOR P57; CYCLIN-DEPENDENT KINASES; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; ENZYME INHIBITORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034733047     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2000.14     Document Type: Article

References (25)

1. Kip1, to regions involved in human cancer. Cancer Res. 55: 1199-1205
2. Chan, F. K., Zhang, J., Shapiro, D. N. and Winoto, A. (1995) Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol. Cell. Biol. 15: 2682-2688
3. Cordon-Cardo, C. (1995) Mutation of cell cycle regulators: biological and clinical implications for human neoplasia. Am. J. Pathol. 147: 545-560
4. Cordon-Cardo C., Koff, A., Drobnjak, M., Capodieci, P., Osman, I., Millard, S. S., Gaudin, P. B., Fazzari, M., Zhang, Z. F., Massague, J. and Scher, H. I. (1998) Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. J. Natl. Cancer. Inst. 90: 1284-1291
5. INK4B/MST2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev. 8: 2939-2952
6. INK4B is a potential effector of TGF-ß- induced cell cycle arrest. Nature 371: 257-261
7. Hirai, H., Roussel, M. F., Kato, J., Ashmun, R. A. and Sherr, C. J. (1995) Novel INK4 proteins , p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell Biol. 15: 2672-2681
8. Hunter, T. and Pines, J. (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79: 573-582
9. Koufos, A., Grundy, P., Morgan, K., Aleck, K. A., Hadro, T., Lampkin, B. C., Kalbakji, A. and Cavenee, W. K. (1989) Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am. J. Hum. Genet. 44: 711-719
10. Lee, M-H., Reynisdottir, I. and Massague, J. (1995) Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 9: 639-649
11. Loh, W. E., Jr, Scrable, H., Livanos, E., Arboleda, M. J., Cavenee, W. K., Oshimura, M. and Weissman, B. E. (1992) Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc. Natl. Acad Sci. USA 89: 1755-1759
12. MacLachlan, T. K., Sang, N. and Giordano, A. (1995) Cyclins, cyclin-dependent kinase and cdk inbihitors: implications in cell cycle control and cancer. Crit. Rev. Eukaryotic Gene Expr. 5: 127-156
13. KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitory family, is a candidate tumor suppressor gene. Genes Dev. 9: 650-662
14. Matsuoka, S., Thompson, J. S., Edwards, M. C., Bartletta, J. M., Grundy, P., Kalikin, L. M., Harper, J. W., Elledge, S. J. and Feinberg, A. P. (1996) Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc. Natl. Acad. Sci. USA 93: 3026-30
15. Montagna, M., Menin, C., Chieco-Bianchi, L. and DAndrea, E. (1994) Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma. J. Cancer Res. Clin. Oncol. 120: 732-736
16. Papadopoulos, P., Ridge, S. A., Boucher, C. A., Stocking, C. and Wiedemann, L. M. (1995) The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res. 55: 34-38
17. Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res. 55: 1206-1210
18. Polyak, K., Lee, M-H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P. and Massague, J. (1994) Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78: 59-66
19. KIP1: chromosomal mapping to 12p21-12p13.1 and absence of mutations in human tumors. Cancer Res. 55: 1211-1214
20. Romana, S. P., Mauchauffe, M., Le Coniat, M., Chumakov, I., Le Paslier, D., Berger, R. and Bernard, O. A. (1995) The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85: 3662-3670
21. Scrable, H., Witte, D., Shimada, H., Seemayer, T., Wang-Wuu, S., Soukup, S., Koufus, A., Houghton, P., Lampkin, B. and Cayenee, W. (1989) Molecular differential pathology of rhabdomyosarcoma. Genes Chromosomes & Cancer 1: 23-35
22. Serrano, M., Hannon, G. J. and Beach. D. (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707
23. Takeuchi, S., Bartram, C. R., Seriu, T., Wada, M., Lee, E. and Koeffler, H. P. (1994) Allelotype of acute lymphoblastic leukemia (ALL) identifies sites of tumor suppressor genes. Blood 84 (suppl. 1): 149a
24. Toyoshima, H. and Hunter, T. (1994) p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78: 67-74
25. Xing, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R. and Beach, D. (1993) p21 is a universal inhibitor of cyclin kinase. Nature (Lond) 366: 701-704