Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats

Chinese Journal of Physiology

Volumn 51, Issue 5, 2008, Pages 292-300

  Tsai, Wen Hui ^a   Cheng, Pao Yun ^b,c   Lee, Yen Mei ^b   Chiu, Min Chen ^b   Jiau, Shyi Shiaw ^d   Wu, Edwin S C ^e   Yen, Mao Hsiung ^b  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e Jenken Biosciences Inc   (United States)

Author keywords

Circulatory failure; Dextromethorphan; Nitric oxide; Reactive oxygen species; Sepsis; TNF

Indexed keywords

3 METHOXYMORPHINAN; 3-METHOXYMORPHINAN; ANTIINFLAMMATORY AGENT; DEXTROMETHORPHAN; DRUG DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRATE; NITRITE; NOS2 PROTEIN, RAT; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; BLOOD PRESSURE; DRUG EFFECT; ENDOTOXEMIA; ENZYMOLOGY; HEART RATE; LIVER; LUNG; MALE; METABOLISM; NEUTROPHIL; RAT; VASOCONSTRICTION; VASODILATATION; WISTAR KYOTO RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; DEXTROMETHORPHAN; ENDOTOXEMIA; HEART RATE; LIPOPOLYSACCHARIDES; LIVER; LUNG; MALE; NEUTROPHILS; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, INBRED WKY; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; VASOCONSTRICTION; VASODILATION;

EID: 60849127584     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ando, H., Takamura, T., Ota, T., Nagai, Y. and Kobayashi, K. Cerivastatin improves survival of mice with lipopolysaccharideinduced sepsis. J. Pharmacol. Exp. Ther. 294: 1043-1046, 2000.
2. Angus, D.C., Linde-Zwirbe, W.T., Lidicker, J., Clermont, G., Carcillo, J. and Pinsky, M.R. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29: 1303-1310, 2001.
3. Beckman, J.S., Beckman, T.W., Chert, J., Marshal1, P.A. and Freeman, B.A. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624, 1990.
4. Bone, R.C., Grodzin, C.J. and Balk, R.A. Sepsis, a new hypothesis for pathogenesis of the disease process. Chest 112: 235-243, 1997.
5. Brix-Christensen, V., Andersen, S.K., Andersen, R., Mengel, A., Dyhr, T., Andersen, N.T., Larsson, A., Schmitz, O., Orskov, H. and Tonnesen, E. Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response. Anesthesiology 100: 861-870, 2004.
6. Cheng, P.Y., Lee, Y.M., Wu, Y.S., Chang, T.W., Jin, J.S. and Yen, M. H. Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro. Biochem. Pharmacol. 73: 793-804, 2007.
7. Choi, D.W. Dextrorphan and dextromethorphan attenuate glutamate neurotoxicity. Brain Res. 403: 333-336, 1987.
8. Deitch, E.A. Multiple organ failure. Pathophysiology and potential future therapy. Ann. Surg. 216: 117-134, 1992.
9. Haberecht, M.F., Mitchell, C.K., Lo, G.J. and Redburn, D.A. NMethyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina. J. Neurosci. Res. 47: 416-426, 1997.
10. Hong, H.J., Loh, S.H. and Yen, M.H. Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase. Brit. J. Pharmacol. 131: 631-637, 2000.
11. Horn, K.D. Evolving strategies in the treatment of sepsis and systemic inflammatory response syndrome (SIRS). QJM 91: 265-277, 1998.
12. Jiang, H., Stewart, C.A. and Leu, R.W. Tumor-derived factor synergizes with IFN-ssand LPS, IL-2 or TNF-aato promote macrophage synthesis of TNF-ssand TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxidemediated tumor cytotoxicity. Immunobiology 192: 321-342, 1995.
13. Kirkebone, K.A. and Stramd, O.A. The role of nitric oxide in sepsis: an overview. Acta. Anaesthesiol. Scand. 43: 275-288, 1999.
14. Kukreja, R.C. and Hess, M.L. The oxygen free radical system: From equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc. Res. 26: 641-655, 1992.
15. Langrehr, J.M., Hoffman, R.A., Lancaster, J.R. and Simmons, R.L. Nitric oxide-a new endogenous immunomodulator. Transplantation 55:1205-1212, 1993.
16. Li, G., Cui, G., Tzeng, N.S., Wei, S.J., Wang, T., Block, M.L. and Hong, J.S. Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB J. 19: 489-496, 2005.
17. Li, G., Liu, Y., Tzeng, N.S., Cui, G., Block, M.L., Wilson, B., Qin, L., Wang, T., Liu, B., Liu, J., and Hong, J.S. Protective effect of dextromethorphan against endotoxicshock in mice. Biochem. Pharmacol. 69:233-240, 2005.
18. Liu, Y., Qin, L., Li, G., Zhang, W., An, L., Liu, B. and Hong, J.S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J. Phannacol. Exp. Ther. 305: 212-218, 2003.
19. Marik, P.E. and Zalopa, G.P. Therapeutic selection: has its time come? Crit. Care Med. 30: 949-952, 2002.
20. Marik, P.E. and Raghavan, M. Stress-hyperglycemia, insulin and immuno-modulation in sepsis. Int. Care Med. 30: 748-756, 2004.
21. Moncada, S., Palmer, R.M. and Higgs, E.A. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
22. Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051-3064; 1992.
23. Sugino, K., Dohi, K., Yamada, K. and Kawasaki, T. Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants. Surgery 105: 200-206, 1989.
24. Szabo, C, Wu, C.C., Gross, S.S., Thiemermann, C. and Vane, J.R. Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. Eur. J. Pharmacol. 250: 157-160, 1993.
25. Szabo, C., Salzman, A.L. and Ischiropoulos, H. Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett. 363: 235-238, 1995.
26. Thiemermann, C. Nitric oxide and septic shock. Gen. Pharmacol. 29: 159-166, 1997.
27. Thiemermann, C., Wu, C.C., Szabo, C., Perretti, M. and Vane, J.R. Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Brit. J. Pharmacol. 110: 177-182, 1993.
28. Titheradge, M.A. Nitric oxide in septic shock. Biochim. Biophys. Acta. 1411: 437-455, 1999.
29. Tortella, F.C., Pellicano, M. and Bowery N.G. Dextromethorphan and neuromodulation: Old drug coughs up new activities. Trends. Pharmacol. Sci. 10:501-507, 1989.
30. Wang, W., Jittikanont, S., Falk, S.A., Li, P., Feng, L., Gengaro, P.E., Poole, B.D., Bowler, R.P., Day, B.J., Crapo, J.D. and Schrie R.W. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am. J. Physiol. 284: F532-F537, 2003.
31. Wu, C.C., Chiao, C.W., Hsiao, G., Chen, A. and Yen M.H. Melatonin prevents endotoxin induced circulatory failure in rats. J. Pineal Res. 30: 147-156, 2001.
32. Wu, C.C., Ruetten, H. and Thiemermann C. Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat. Eur. J. Pharmacol. 300: 99-104, 1996.
33. Yang, F., Comtois, A.S., Fang, L., Hartman, N.G. and Blaise, G. Nitric oxide-derived nitrate anion contributes to endotoxic shock and multiple organ injury/dysfunction. Crit. Care Med. 30: 650-657, 2002.