Characterization and application of two novel monoclonal antibodies against human CXCR4: Cell proliferation and migration regulation for glioma cell line in vitro by CXCR4/SDF-1α signal

Hybridoma

Volumn 28, Issue 1, 2009, Pages 33-41

  Cheng, Zhongqin ^a   Zhou, Shiyong ^a   Wang, Xuefeng ^a   Xie, Fang ^a   Wu, Hongya ^a   Liu, Gaoqin ^a   Wang, Qin ^a   Chen, Yongjin ^a   Hu, Yumin ^a   Lu, Binfeng ^a   Zhang, Xueguang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CHEMOKINE RECEPTOR CXCR4; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 6H7; MONOCLONAL ANTIBODY 7D4; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CD4+ T LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; FLOW CYTOMETRY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR CELL; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITOPE MAPPING; FLOW CYTOMETRY; GLIOMA; HUMANS; HYBRIDOMAS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED BALB C; RECEPTORS, CXCR4;

EID: 60849126162     PISSN: 15540014     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.2008.0069     Document Type: Article

References (30)

1. Nagasawa T, Kikutani H, and Kishimoto T: Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci USA 1994:91:2305-2309.
2. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, and Kishimoto T: Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1α. Nature 1996:382;635-638.
3. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, and Littman DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998:393;595-599.
4. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, and Springer TA: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1α- deficient mice. Proc Natl Acad Sci USA 1998:95;9448-9453.
5. Fran B: The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 2004:14;17-19.
6. Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verástegui E, and Zlotnik A: Involvement of chemokine receptors in breast cancer metastasis. Nature 2001:410;50-56.
7. Liang Z, Yoon Y, Votaw J, Goodman MM, Williams L, and Shim H: Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res 2005:65;967-971.
8. Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, Beider K, Avniel S, Kasem S, Galun E, and Peled A: Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004:18;1240-1242.
9. Burger JA, Burger M, and Kipps TJ: Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 1999:94;3658-3667.
10. Sun YX, Wang J, Shelburne CE, Lopatin DE, Chinnaiyan AM, Rubin MA, Pienta KJ, and Taichman RS: Expression of CXCR4 and CXCL12(SDF-1α) in human prostate cancers (PCa) in vivo. J Cell Biochem 2003:89;462-473.
11. Sehgal A, Keener C, Boynton AL, Warrick J, and Murphy GP: CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells. J Surg Oncol 1998:69;99-104.
12. Kato M, Kitayama J, Kazama S, and Nagawa H: Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 2003:5;144-150.
13. Chen SN, Xue YQ, Zhang XG, Wu YF, Pan JL, Wang Y, and Cen JN: Establishment and characterization of a human acute monocytic leukemic cell line, SHI-1, carrying t(6;11) (q27;q23) and p53 gene alteration. Zhonghua Xue Ye Xue Za Zhi 2005:26;94-99.
14. Wang XF, Chen YJ, Wang Q, Ge Y, Dai Q, Yang KF, Fang-Xie, Zhou YH, Hu YM, Mao YX, and Zhang XG: Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells. Tissue Antigens 2007:69;145-153.
15. Groth SF, and Scheidegger D: Production of monoclonal antibodies: strategytactics. J Immunol Methods 1980:35;1-12.
16. Xie F, Wang Q, Chen Y, Gu Y, Shi Q, Ge Y, Yu G, Wu H, Mao Y, Wang X, Zhou Y, and Zhang X: Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues. Tissue Antigens 2006:67;307-317.
17. Feng Y, Broder CC, Kennedy PE, and Berger EA: HIV-1entry cofactor:functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996:272;872-877.
18. Xue Q, Miao ZN, Qu J, Shi Q, Chen YJ, and Zhang XG: The gp130 signal increases the expression of CXCR4 on the neural progenitor cells. Mod Immunol China 2005:25;117-121.
19. Rempel SA, Dudas S, Ge S, and Gutiérrez JA: Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 2000:1;102-111.
20. Huang X, Shen J, Cui M, Shen L, Luo X, Ling K, Pei G, Jiang H, and Chen K: Molecular dynamics simulations on SDF-1alpha binding with CXCR4 recetor. Biophys J 2003:84;171-184.
21. Brelot A, Heveker N, Montes M, and Alizon M: Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities. J Biol Chem 2000:275;23736-23744.
22. Zhou N, Luo Z, Luo J, Liu D, Hall JW, Pomerantz RJ, and Huang Z: Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies. J Biol Chem 2001:276;42826-42833.
23. Baribaud F, Edwards TG, Sharron M, Brelot A, Heveker N, Price K, Mortari F, Alizon M, Tsang M, and Doms RW: Antigenically distinct conformations of CXCR4. J Virol 2001:75;8957-8967.
24. Endres MJ, Clapham PR, Marsh M, Ahuja M, Turner JD, McKnight A, Thomas JF, Stoebenau-Haggarty B, Choe S, Vance PJ, Wells TN, Power CA, Sutterwala SS, Doms RW, Landau NR, and Hoxie JA: CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell 1996:87;745-756.
25. Zlotnik A: Chemokines and cancer. Int J Cancer 2006:119;2026-2029.
26. Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, Fujii N, Amagai T, and Nagasawa T: A role of CXC chemokine ligand 12 stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol 2003:170;4649-4655.
27. Schabath R, Müller G, Schubel A, Kremmer E, Lipp M, and Forster R: The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation. J Leukocyte Biol 1999:66;996-1004.
28. Bleul CC, Wu L, Hoxie JA, Springer TA, and Mackay CR: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997:94;1925-1930.
29. Mohaghegheghpour N, Chakrabarti R, and Stein S: Early activation events render T cells susceptible to HIV-1-induced syncytia formation. Role of protein kinase C. J Biol Chem 1991:266;7233-7238.
30. Zhou Y, Larsen PH, Hao C, and Yong VW: CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 2002:277;49481-49487.