Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children

BMC Psychiatry

Volumn 9, Issue , 2009, Pages

  Mick, Eric ^a   Wozniak, Janet ^a   Wilens, Timothy E ^a   Biederman, Joseph ^a   Faraone, Stephen V ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; SEROTONIN TRANSPORTER;

ADOLESCENT; ALLELE; ARTICLE; BIPOLAR I DISORDER; CHILD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENERAL HOSPITAL; GENETIC ASSOCIATION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PEDIGREE ANALYSIS; PROGENY; UNITED STATES; ADULT; AGE; BIPOLAR DISORDER; GENETIC PREDISPOSITION; GENETICS; NUCLEAR FAMILY;

ADOLESCENT; ADULT; AGE FACTORS; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATECHOL O-METHYLTRANSFERASE; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; NUCLEAR FAMILY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 60849125106     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-9-2     Document Type: Article

References (53)

1. Carlson GA Bipolar Affective Disorders in Childhood and Adolescence Affective Disorders in Childhood and Adolescence: An Update New York: Spectrum Publications Cantwell DP, Carlson GA 1983, 61-83
2. McElroy SL Keck JPE Pope JHG Hudson JI Faedda G Swann AC Clinical and research implications of the diagnosis of dysphoric or mixed mania or hypomania American Journal of Psychiatry 1992, 149:1633-1644 1359799
3. Biederman J Mick E Faraone SV Van Patten S Burback M Wozniak J A Prospective Follow Up Study of Pediatric Bipolar Disorder in boys with attention deficit/hyperactivity disorder Journal of Affective Disorders 2004, 82S:S17-S23 10.1016/j.jad.2004.05.012
4. Geller B Williams M Zimerman B Frazier J Beringer L Warner K Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling Journal of Affective Disorders 1998, 51:81-91 10.1016/S0165-0327(98)00175-X 10743841
5. Geller B Craney JL Bolhofner K DelBello MP Williams M Zimerman B One-Year Recovery and Relapse Rates of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype American Journal of Psychiatry 2001, 158:303-305 10.1176/appi.ajp.158.2.303 11156815
6. Geller B Tillman R Bolhofner K Zimerman B Strauss NA Kaufmann P Controlled, blindly rated, direct-interview family study of a prepubertal and early-adolescent bipolar I disorder phenotype: Morbid risk, age at onset, and comorbidity Arch Gen Psychiatry 2006, 63:1130-1138 10.1001/archpsyc.63.10.1130 17015815
7. Birmaher B Axelson D Strober M Gill MK Valeri S Chiappetta L Ryan N Leonard H Hunt J Iyengar S Keller M Clinical course of children and adolescents with bipolar spectrum disorders Arch Gen Psychiatry 2006, 63:175-183 10.1001/archpsyc.63.2.175 16461861
8. Brotman MA Kassem L Reising MM Guyer AE Dickstein DP Rich BA Towbin KE Pine DS McMahon FJ Leibenluft E Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation Am J Psychiatry 2007, 164:1238-1241 10.1176/appi.ajp.2007.06101619 17671287
9. Wozniak J Biederman J Kiely K Ablon S Faraone S Mundy E Mennin D Mania-like symptoms suggestive of childhood onset bipolar disorder in clinically referred children J Am Acad Child Adolesc Psychiatry 1995, 34(7):867-876 7649957 10.1097/00004583-199507000-00010
10. Findling RL Gracious BL McNamara NK Youngstrom EA Demeter CA Branicky LA Calabrese JR Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder Bipolar Disorders 2001, 3:202-210 10.1034/ j.1399-5618.2001.30405.x 11552959
11. Wilens TE Biederman J Adamson JJ Henin A Sgambati S Gignac M Sawtelle R Santry A Monuteaux MC Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study Drug Alcohol Depend 2008, 95:188-198 10.1016/ j.drugalcdep.2007.12.016 18343050
12. Tsuang MT Faraone SV The Genetics of Mood Disorders Baltimore: The John Hopkins University Press 1990
13. Cardno AG Marshall EJ Coid B Macdonald AM Ribchester TR Davies NJ Venturi P Jones LA Lewis SW Sham PC Gottesman II Farmer AE McGuffin P Reveley AM Murray RM Heritability estimates for psychotic disorders: The Maudsley twin psychosis series Arch Gen Psychiatry 1999, 56:162-168 10.1001/archpsyc.56.2.162 10025441
14. Kendler KS Pedersen N Johnson L Neale MC Mathe AA A pilot Swedish twin study of affective illness, including hospital- and population-ascertained subsamples Arch Gen Psychiatry 1993, 50:699-700 8357295
15. Kendler KS Pedersen NL Neale MC Mathe AA A pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: Results of model fitting Behav Genet 1995, 25:217-232 10.1007/BF02197180 7598665
16. Kieseppa T Partonen T Haukka J Kaprio J Lonnqvist J High concordance of bipolar I disorder in a nationwide sample of twins Am J Psychiatry 2004, 161:1814-1821 10.1176/appi.ajp.161.10.1814 15465978
17. McGuffin P Rijsdijk F Andrew M Sham P Katz R Cardno A The heritability of bipolar affective disorder and the genetic relationship to unipolar depression Arch Gen Psychiatry 2003, 60:497-502 10.1001/ archpsyc.60.5.497 12742871
18. Smoller JW Finn CT Family, twin, and adoption studies of bipolar disorder American Journal of Medical Genetics 2003, 123C:48 10.1002/ ajmg.c.20013 14601036
19. Dwyer JT DeLong GR A family history study of twenty probands with childhood manic-depressive illness J Am Acad Child Adolesc Psychiatry 1987, 26:176-180 10.1097/00004583-198703000-00009 3584013
20. Kutcher S Marton P Affective disorders in first-degree relatives of adolescent onset bipolars, unipolars, and normal controls J Am Acad Child Adolesc Psychiatry 1991, 30:75-78 2005067
21. Neuman RJ Geller B Rice JP Todd RD Increased prevalence and earlier onset of mood disorders among relatives of prepubertal versus adult probands J Am Acad Child Adolesc Psychiatry 1997, 36:466-473 10.1097/ 00004583-199704000-00008 9100420
22. Strober M Morrell W Burroughs J Lampert C Danforth H Freeman R A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance J Affect Disord 1988, 15:255-268 10.1016/0165-0327(88)90023-7 2975298
23. Wozniak J Biederman J Mundy E Mennin D Faraone SV A pilot family study of childhood-onset mania J Am Acad Child Adolesc Psychiatry 1995, 34:1577-1583 10.1097/00004583-199512000-00007 8543528
24. Wilens TE Biederman J Adamson J Monuteaux M Henin A Sgambati S Santry A Faraone SV Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder Biol Psychiatry 2007, 62:129-134 10.1016/j.biopsych.2006.11.022 17481590
25. Craddock N Forty L Genetics of affective (mood) disorders Eur J Hum Genet 2006, 14:660-668 10.1038/sj.ejhg.5201549 16721402
26. Geller B Cook E Serotonin transporter gene (HTTLPR) is not in linkage disequilibrium with prepubertal and early adolescent bipolarity Biological Psychiatry 1999, 45:1230-1233 10.1016/S0006-3223(98)00362-X 10331118
27. Geller B Cook EH Jr Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with val/met COMT alleles Biological Psychiatry 2000, 47:605-609 10.1016/ S0006-3223(99)00251-6 10745052
28. Geller B Badner JA Tillman R Christian SL Bolhofner K Cook EH Jr Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype The American Journal of Psychiatry 2004, 161:1698 10.1176/appi.ajp.161.9.1698 15337662
29. Geller B Tillman R Bolhofner K Hennessy K Cook EH Jr GAD1 single nucleotide polymorphism is in linkage disequilibrium with a child bipolar I disorder phenotype J Child Adolesc Psychopharmacol 2008, 18:25-29 10.1089/cap.2007.0056 18294085
30. Lesch K Bengel D Heils A Sabol S Greenberg B Petri S Benjamin J Muller C Hamer D Murphy D Association of anxiety-related traits with a polymorphism in the serotinin transporter gene regulatory region Science 1996, 274:1527-1532 10.1126/science.274.5292.1527 8929413
31. Axelrod J Tomchick R Enzymatic O-methylation of epinephrine and other catechols J Biol Chem 1958, 233:702-705 13575440
32. Lachman HM Papolos DF Saito T Yu YM Szumlanski CL Weinshilboum RM Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders Pharmacogenetics 1996, 6:243-250 10.1097/ 00008571-199606000-00007 8807664
33. Rylett RJ Williams LR Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS Trends Neurosci 1994, 17:486-490 10.1016/0166-2236(94)90138-4 7531891
34. Egan MF Kojima M Callicott JH Goldberg TE Kolachana BS Bertolino A Zaitsev E Gold B Goldman D Dean M Lu B Weinberger DR The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 2003, 112:257-269 10.1016/ S0092-8674(03)00035-7 12553913
35. Erlander MG Tillakaratne NJ Feldblum S Patel N Tobin AJ Two genes encode distinct glutamate decarboxylases Neuron 1991, 7:91-100 10.1016/ 0896-6273(91)90077-D 2069816
36. Bu DF Tobin AJ The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD Genomics 1994, 21:222-228 10.1006/geno.1994.1246 8088791
37. Addington AM Gornick M Duckworth J Sporn A Gogtay N Bobb A Greenstein D Lenane M Gochman P Baker N Balkissoon R Vakkalanka RK Weinberger DR Rapoport JL Straub RE GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss Mol Psychiatry 2005, 10:581-588 10.1038/sj.mp.4001599 15505639
38. Madras BK Miller GM Fischman AJ The dopamine transporter: Relevance to attention deficit hyperactivity disorder (ADHD) Behavioural Brain Research 2002, 130:57-63 10.1016/S0166-4328(01)00439-9 11864718
39. Madras BK Miller GM Fischman AJ The dopamine transporter and attention-deficit/hyperactivity disorder Biol Psychiatry 2005, 57:1397-1409 10.1016/j.biopsych.2004.10.011 15950014
40. Mick E Kim JW Biederman J Wozniak J Wilens T Spencer T Smoller JW Faraone SV Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3) Am J Med Genet B Neuropsychiatr Genet 2008, 147B:1182-1185 10.1002/ajmg.b.30745 18361424
41. Biederman J Monuteaux M Mick E Spencer T Wilens T Silva J Snyder L Faraone SV Young Adult Outcome of Attention Deficit Hyperactivity Disorder: A Controlled 10 year Prospective Follow-Up Study Psychological Medicine 2006, 36:167-179 10.1017/S0033291705006410 16420713
42. Biederman J Monuteaux MC Mick E Spencer T Wilens TE Klein KL Price JE Faraone SV Psychopathology in females with attention-deficit/ hyperactivity disorder: A controlled, five-year prospective study Biol Psychiatry 2006, 60:1098-1105 10.1016/j.biopsych.2006.02.031 16712802
43. Faraone SV Biederman J Spencer T Mick E Murray K Petty C Adamson JJ Monuteaux MC Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid? Am J Psychiatry 2006, 163:1720-1729 10.1176/appi.ajp.163.10.1720 17012682
44. Wozniak J Biederman J Kwon A Mick E Faraone SV Orlovsky K Schnare L Cargol C Van Grondelle A How cardinal are cardinal symptoms in pediatric bipolar disorder?: An examination of clinical correlates Biological Psychiatry 2005, 58:583-588 10.1016/j.biopsych.2005.08.014 16197929
45. Orvaschel H Schedule for Affective Disorder and Schizophrenia for School-Age Children Epidemiologic Version Ft. Lauderdale: Nova Southeastern University, Center for Psychological Studies 5 1994
46. First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV) Washington, DC: American Psychiatric Press 1997
47. Sklar P Gabriel SB McInnis MG Bennett P Lim YM Tsan G Schaffner S Kirov G Jones I Owen M Craddock N DePaulo JR Lander ES Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor Mol Psychiatry 2002, 7:579-593 10.1038/sj.mp.4001058 12140781
48. Purcell S Neale B Todd-Brown K Thomas L Ferreira MA Bender D Maller J Sklar P de Bakker PI Daly MJ Sham PC PLINK: A tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 2007, 81:559-575 1950838 17701901 10.1086/519795
49. Baum AE Akula N Cabanero M Cardona I Corona W Klemens B Schulze TG Cichon S Rietschel M Nothen MM Georgi A Schumacher J Schwarz M Abou Jamra R Hofels S Propping P Satagopan J Detera-Wadleigh SD Hardy J McMahon FJ A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder Mol Psychiatry 2008, 13:197-207 2527618 17486107 10.1038/ sj.mp.4002012
50. Baum AE Hamshere M Green E Cichon S Rietschel M Noethen MM Craddock N McMahon FJ Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement Mol Psychiatry 2008, 13:466-467 2435183 18421293 10.1038/mp.2008.16
51. Sklar P Smoller JW Fan J Ferreira MA Perlis RH Chambert K Nimgaonkar VL McQueen MB Faraone SV Kirby A de Bakker PI Ogdie MN Thase ME Sachs GS Todd-Brown K Gabriel SB Sougnez C Gates C Blumenstiel B Defelice M Ardlie KG Franklin J Muir WJ McGhee KA Macintyre DJ McLean A Vanbeck M McQuillin A Bass NJ Robinson M Lawrence J Anjorin A Curtis D Scolnick EM Daly MJ Blackwood DH Gurling HM Purcell SM Whole-genome association study of bipolar disorder Mol Psychiatry 2008, 13:558-569 10.1038/ sj.mp.4002151 18317468
52. WTCCC TWTCCC Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007, 447:661-678 10.1038/nature05911 17554300
53. Pandey GN Rizavi HS Dwivedi Y Pavuluri MN Brain-Derived Neurotrophic Factor Gene Expression in Pediatric Bipolar Disorder: Effects of Treatment and Clinical Response J Am Acad Child Adolesc Psychiatry 2008 18664999