-
1
-
-
84890597202
-
-
For overviews, see: a) J. Zhu, H. Bienaymé Eds, Wiley-VCH, Weinheim
-
For overviews, see: a) J. Zhu, H. Bienaymé (Eds.), Multicompo-nent reactions, Wiley-VCH, Weinheim, 2005;
-
(2005)
Multicompo-nent reactions
-
-
-
2
-
-
84890766709
-
-
L. F. Tietze, G. Brasche, K. M. Gericke Eds, Wiley-VCH, Weinheim
-
b) L. F. Tietze, G. Brasche, K. M. Gericke (Eds.), Domino reactions in Organic Synthesis, Wiley-VCH, Weinheim, 2006;
-
(2006)
Domino reactions in Organic Synthesis
-
-
-
3
-
-
2542509173
-
-
For recent reviews, see: cA. Dömling, I. Ugi, Angew. Chem. Int. Ed. 2000, 39, 3168-3210; Angew. Chem. 2000, 112, 3300-3344;
-
For recent reviews, see: c)A. Dömling, I. Ugi, Angew. Chem. Int. Ed. 2000, 39, 3168-3210; Angew. Chem. 2000, 112, 3300-3344;
-
-
-
-
4
-
-
0034665244
-
-
H. Bienaymé,C.Hulme, G. Oddon, P. Schmitt, Chem. Eur. J. 2000, 6, 3321-3329;
-
(2000)
Chem. Eur. J
, vol.6
, pp. 3321-3329
-
-
Bienaymé, H.1
Hulme, C.2
Oddon, G.3
Schmitt, P.4
-
8
-
-
23044445558
-
-
Angew. Chem. 2005, 117, 1628-1661;
-
(2005)
Angew. Chem
, vol.117
, pp. 1628-1661
-
-
-
9
-
-
31544434530
-
-
h) A. Dömling, Chem. Rev. 2006,106,17-89;
-
(2006)
Chem. Rev
, vol.106
, pp. 17-89
-
-
Dömling, A.1
-
10
-
-
33750977591
-
-
K. C. Nicolaou, D. J. Edmonds, P. G. Bulger, Angew. Chem. Int. Ed. 2006, 45, 7134-7186;
-
(2006)
Angew. Chem. Int. Ed
, vol.45
, pp. 7134-7186
-
-
Nicolaou, K.C.1
Edmonds, D.J.2
Bulger, P.G.3
-
11
-
-
33847207721
-
-
Angew. Chem. 2006, 118, 7292-7344.
-
(2006)
Angew. Chem
, vol.118
, pp. 7292-7344
-
-
-
12
-
-
0038042482
-
-
a) C. Merlot, D. Domine, C. Cleva, D. J. Church, Drug Discov. Today 2003, 8, 594-602;
-
(2003)
Drug Discov. Today
, vol.8
, pp. 594-602
-
-
Merlot, C.1
Domine, D.2
Cleva, C.3
Church, D.J.4
-
14
-
-
0037366605
-
-
D. A. Horton, G. T. Bourne,M. L. Symthe, Chem. Rev. 2003, 103, 893-930.
-
(2003)
Chem. Rev
, vol.103
, pp. 893-930
-
-
Horton, D.A.1
Bourne, G.T.2
Symthe, M.L.3
-
15
-
-
34250021382
-
-
For a heterocyclic domino process, including MCRs, see: a
-
For a heterocyclic domino process, including MCRs, see: a) A. Padwa, S. K. Bur, Tetrahedron 2007, 63, 5341-5378;
-
(2007)
Tetrahedron
, vol.63
, pp. 5341-5378
-
-
Padwa, A.1
Bur, S.K.2
-
16
-
-
53849120603
-
-
for a review on MCRs involving heterocycles, see: N. Isambert, R. Lavilla, Chem. Eur. J. 2008, 8444-8454.
-
b) for a review on MCRs involving heterocycles, see: N. Isambert, R. Lavilla, Chem. Eur. J. 2008, 8444-8454.
-
-
-
-
17
-
-
17744403755
-
-
a) J. L. Díaz, M. Miguel, R. Lavilla, J. Org. Chem. 2004, 69,3550-3553;
-
(2004)
J. Org. Chem
, vol.69
, pp. 3550-3553
-
-
Díaz, J.L.1
Miguel, M.2
Lavilla, R.3
-
18
-
-
13544253604
-
-
b) I. Carranco, J. L. D az, O. Jiménez, M. Vendrell, F. Albericio, M. Royo, R. Lavilla, J. Comb. Chem. 2005, 7,33-41;
-
(2005)
J. Comb. Chem
, vol.7
, pp. 33-41
-
-
Carranco, I.1
az, J.L.D.2
Jiménez, O.3
Vendrell, M.4
Albericio, F.5
Royo, M.6
Lavilla, R.7
-
19
-
-
27144508168
-
-
O. Jiménez, G. de la Rosa, R. Lavilla, Angew. Chem. Int.Ed. 2005, 44, 6521-6525;
-
(2005)
Angew. Chem. Int.Ed
, vol.44
, pp. 6521-6525
-
-
Jiménez, O.1
de la Rosa, G.2
Lavilla, R.3
-
20
-
-
33846590858
-
-
Angew. Chem. 2005, 117, 6679-6683;
-
(2005)
Angew. Chem
, vol.117
, pp. 6679-6683
-
-
-
21
-
-
35548962875
-
-
N. Isambert, M. Cruz, M. J. Arévalo, E. Gómez, R. Lavilla,Org. Lett. 2007, 9, 4199-4202;
-
(2007)
Org. Lett
, vol.9
, pp. 4199-4202
-
-
Isambert, N.1
Cruz, M.2
Arévalo, M.J.3
Gómez, E.4
Lavilla, R.5
-
22
-
-
34250831544
-
-
e) C. Masdeu, E. Gómez, N. A. O. Williams, R. Lavilla, Angew. Chem. Int. Ed. 2007, 46,3043-3046;
-
(2007)
Angew. Chem. Int. Ed
, vol.46
, pp. 3043-3046
-
-
Masdeu, C.1
Gómez, E.2
Williams, N.A.O.3
Lavilla, R.4
-
23
-
-
53549131119
-
-
Angew. Chem. 2007, 119, 3103-3106.
-
(2007)
Angew. Chem
, vol.119
, pp. 3103-3106
-
-
-
24
-
-
42049087420
-
-
and references cited therein;
-
a) C. G. Newton, C. A. Ramsden, Tetrahedron 1982, 38, 2965-3011, and references cited therein;
-
(1982)
Tetrahedron
, vol.38
, pp. 2965-3011
-
-
Newton, C.G.1
Ramsden, C.A.2
-
25
-
-
0000069238
-
-
Ed, C. J. Moody, JAI Press, Greenwich, CT
-
b) L. S. Beall, A. Padwa in Advances in Nitrogen Heterocycles (Ed.: C. J. Moody), JAI Press, Greenwich, CT, 1998,vol.3,pp. 117-158.
-
(1998)
Advances in Nitrogen Heterocycles
, vol.3
, pp. 117-158
-
-
Beall, L.S.1
Padwa, A.2
-
26
-
-
33847080427
-
-
a) D. J. St. Cyr, N. Martin, B. A. Arndtsen, Org. Lett. 2007, 9,449-452;
-
(2007)
Org. Lett
, vol.9
, pp. 449-452
-
-
St. Cyr, D.J.1
Martin, N.2
Arndtsen, B.A.3
-
27
-
-
15444372252
-
-
In this latter case, the process presumably involves the electrophilic activation of the isocyanide component by the isothiocyanate
-
b) M. A. Mironov, S. S. Maltsev, V. S. Morushin,V. A. Bakulev, Mol. Diversity 2005, 9, 221-227. In this latter case, the process presumably involves the electrophilic activation of the isocyanide component by the isothiocyanate.
-
(2005)
Mol. Diversity
, vol.9
, pp. 221-227
-
-
Mironov, M.A.1
Maltsev, S.S.2
Morushin, V.S.3
Bakulev, V.A.4
-
29
-
-
60849120305
-
-
2 = 0.0906. CCDC-684676 contains the supplementary crystallographic The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/ cif.
-
2 = 0.0906. CCDC-684676 contains the supplementary crystallographic The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/ cif.
-
-
-
-
30
-
-
0032514523
-
-
C. J. Moody, S. Miah, A. M. Z. Slawin, D. J. Mansfield, I. C. Richards, Tetrahedron 1998, 54, 9689-9700.
-
(1998)
Tetrahedron
, vol.54
, pp. 9689-9700
-
-
Moody, C.J.1
Miah, S.2
Slawin, A.M.Z.3
Mansfield, D.J.4
Richards, I.C.5
-
33
-
-
4644220952
-
-
L. El Kaïm, L. Gaultier, L. Grimaud, E. Vieu, Tetrahedron Lett. 2004, 45, 8047-8048;
-
(2004)
Tetrahedron Lett
, vol.45
, pp. 8047-8048
-
-
El Kaïm, L.1
Gaultier, L.2
Grimaud, L.3
Vieu, E.4
-
34
-
-
3042670427
-
-
see also
-
see also: T. Colin, L. El Kaïm,L. Gaultier, L. Grimaud, L. Gatay, V. Michaut, Tetrahedron Lett. 2004, 45, 5611-5613;
-
(2004)
Tetrahedron Lett
, vol.45
, pp. 5611-5613
-
-
Colin, T.1
El Kaïm, L.2
Gaultier, L.3
Grimaud, L.4
Gatay, L.5
Michaut, V.6
-
35
-
-
60849112717
-
-
this interesting possibility was kindly suggested by a referee
-
e) this interesting possibility was kindly suggested by a referee.
-
-
-
-
37
-
-
21644433381
-
-
b) S. M. Igumnov, G. I. Lekontseva, A. A. Shipigusev, V. F. Mukhametshin, Russ. J. Appl. Chem. 2005, 78, 435-437;
-
(2005)
Russ. J. Appl. Chem
, vol.78
, pp. 435-437
-
-
Igumnov, S.M.1
Lekontseva, G.I.2
Shipigusev, A.A.3
Mukhametshin, V.F.4
-
41
-
-
84981760993
-
-
For some examples of the double insertion of isocyanides at electrophilic centers, see: a
-
For some examples of the double insertion of isocyanides at electrophilic centers, see: a) H. J. Kabbe, Chem. Ber. 1969, 102,1404-1409;
-
(1969)
Chem. Ber
, vol.102
, pp. 1404-1409
-
-
Kabbe, H.J.1
-
43
-
-
12944307854
-
-
M. Oshita, K. Yamashita, M. Tobisu, N. Chatani, J. Am. Chem. Soc. 2005, 127, 761-766;
-
(2005)
J. Am. Chem. Soc
, vol.127
, pp. 761-766
-
-
Oshita, M.1
Yamashita, K.2
Tobisu, M.3
Chatani, N.4
-
45
-
-
60849137720
-
-
Also see refs.[3a,3e
-
[3a,3e].
-
-
-
-
46
-
-
19944370115
-
-
and references cited therein. See, for instance
-
See, for instance: S. Montiel-Smith, S. Meza-Reyes, O. Viñas-Bravo, M. A. Fernández-Herrera, R. Martínez-Pascual, J. San-doval-Ramírez, A. Fuente, M. Reyes, J. A. Ruiz, ARKIVOC 2005, 127-135, and references cited therein.
-
(2005)
ARKIVOC
, pp. 127-135
-
-
Montiel-Smith, S.1
Meza-Reyes, S.2
Viñas-Bravo, O.3
Fernández-Herrera, M.A.4
Martínez-Pascual, R.5
San-doval-Ramírez, J.6
Fuente, A.7
Reyes, M.8
Ruiz, J.A.9
-
47
-
-
60849138258
-
-
2 = 0.0866. CCDC-684677 contains the supplementary crystallographic data for 5p. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/cif.
-
2 = 0.0866. CCDC-684677 contains the supplementary crystallographic data for 5p. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data-request/cif.
-
-
-
-
48
-
-
0028000622
-
-
The addition of trichloromethyl anions (by decarboxylation of sodium trichloroacetate) to N-alkylazinium salts has been reported: M. Grignon-Dubois, F. Diaba, M.-C. Grellier-Marly,Synthesis 1994, 800-804.
-
The addition of trichloromethyl anions (by decarboxylation of sodium trichloroacetate) to N-alkylazinium salts has been reported: M. Grignon-Dubois, F. Diaba, M.-C. Grellier-Marly,Synthesis 1994, 800-804.
-
-
-
-
49
-
-
37849046429
-
-
a) A. M. Palmer, B. Grobbel, C. Jecke, C. Brehm, P. J. Zimmer-mann, W. Burh, M. P. Feth, W.-A. Simon, W. Kroemer, J. Med. Chem. 2007, 50, 6240-6264;
-
(2007)
J. Med. Chem
, vol.50
, pp. 6240-6264
-
-
Palmer, A.M.1
Grobbel, B.2
Jecke, C.3
Brehm, C.4
Zimmer-mann, P.J.5
Burh, W.6
Feth, M.P.7
Simon, W.-A.8
Kroemer, W.9
-
50
-
-
37849003729
-
-
b) L. Cai, J.-S. Liow, S. S. Zoghbi,J. Cuevas, C. Baetas, J. Hong, H. U. Shetty, N. M. Seneca, A. K. Brown, R. Gladding, S. S. Temme, M. H. Herman, R. B. Innis, V. W. Pike, J. Med. Chem. 2008, 51, 148-158;
-
(2008)
J. Med. Chem
, vol.51
, pp. 148-158
-
-
Cai, L.1
Liow, J.-S.2
Zoghbi, S.S.3
Cuevas, J.4
Baetas, C.5
Hong, J.6
Shetty, H.U.7
Seneca, N.M.8
Brown, A.K.9
Gladding, R.10
Temme, S.S.11
Herman, M.H.12
Innis, R.B.13
Pike, V.W.14
-
53
-
-
0013103264
-
-
Angew. Chem. 1998, 110, 2349-2352;
-
(1998)
Angew. Chem
, vol.110
, pp. 2349-2352
-
-
-
54
-
-
0032575201
-
-
b) C. Blackburn, B. Guan, P. Fleming, K. Shiosaki, S. Tsai, Tetrahedron Lett. 1998, 39, 3635-3638;
-
(1998)
Tetrahedron Lett
, vol.39
, pp. 3635-3638
-
-
Blackburn, C.1
Guan, B.2
Fleming, P.3
Shiosaki, K.4
Tsai, S.5
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