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For recent reviews of the Mannich reaction, see: (a) Kleinman, E. F. In Comprehensive Organic Synthesis; Trost, B. M., Fleming, I., Eds.; Pergamon Press: New York, 1991; Vol. 2, Chapter 4.1.
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35549010503
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Minute amounts of compound A were detected in some experiments NMR and MS evidence
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Minute amounts of compound A were detected in some experiments (NMR and MS evidence).
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-
-
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30
-
-
35248848733
-
-
To the best of our knowledge, this is an unreported transformation. For a related process, see
-
To the best of our knowledge, this is an unreported transformation. For a related process, see: Baydar, A. E.; Boyd, G. V.; Monteil, R. L.; Lindley, P. F.; Mahmoud, M. M. Chem. Commun. 1976..650.
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0007835164
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For the stepwise synthesis of these compounds, see: (a) Takei, H.; Fukuda, Y.; Sugaya, K.; Taguchi, T.; Kawara, T. Chem. Lett. 1980, 1307.
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35549003909
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This ratio of stereoisomers seems to be the usual outcome for this kind of processes. For related results, see refs 3 and 4
-
This ratio of stereoisomers seems to be the usual outcome for this kind of processes. For related results, see refs 3 and 4.
-
-
-
-
38
-
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33745431146
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For a recent example, see
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For a recent example, see: More, S. V.; Sastry, M. N. V.; Yao, C.-F. Synlett 2006, 1399.
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More, S.V.1
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39
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35548975633
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-
In agreement with preliminar calculations (AMI) on the relative stability of cis and trans isomers
-
In agreement with preliminar calculations (AMI) on the relative stability of cis and trans isomers.
-
-
-
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40
-
-
33947448210
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-
The corresponding carboxylic acid is described: Buehler, C. A.; Edwards, S. P. J. Am Chem. Soc. 1952, 74, 977.
-
The corresponding carboxylic acid is described: Buehler, C. A.; Edwards, S. P. J. Am Chem. Soc. 1952, 74, 977.
-
-
-
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41
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-
33845322646
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-
Quinoline 5b has previously been described: Alves, M. J.; Azoia, N. G.; Gil Fortes, A. Tetrahedron 2007, 63, 727.
-
Quinoline 5b has previously been described: Alves, M. J.; Azoia, N. G.; Gil Fortes, A. Tetrahedron 2007, 63, 727.
-
-
-
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42
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0343081039
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See, for instance
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See, for instance: Crousse, B.; Bégué, J.-P.; Bonnet-Delpon, D. J. Org. Chem. 2000, 65, 5009.
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43
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0001296532
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For a related transformation involving the more reactive Nacyliminium ions, see: a
-
For a related transformation involving the more reactive Nacyliminium ions, see: (a) Katritzky, A. R.; Ignatchenko, A. V.; Lang, H. J. Org. Chem 1995, 60, 4002.
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35548954516
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Meester, W. J. N.; van Maarseveen, J. H.; Kirchsteiger, K.; Hermkens, P. H: H.; Schoemaker, H. E.; Hiemstra, H.; Rutjes, F. P. J. T. Arkivoc 2004, 122.
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(b) Meester, W. J. N.; van Maarseveen, J. H.; Kirchsteiger, K.; Hermkens, P. H: H.; Schoemaker, H. E.; Hiemstra, H.; Rutjes, F. P. J. T. Arkivoc 2004, 122.
-
-
-
-
45
-
-
35549007451
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-
In this case, the stereochemical complexity of the resulting double lactam was simplified by the acid-catalyzed isomerization to yield a major trans-trans stereoisomer of unknown relative stereochemistry
-
In this case, the stereochemical complexity of the resulting double lactam was simplified by the acid-catalyzed isomerization to yield a major trans-trans stereoisomer of unknown relative stereochemistry.
-
-
-
-
46
-
-
0037420331
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For a recent result, see
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For a recent result, see: Kobayashi, S.; Matsubara, R.; Nakamura, Y.; Kitagawa, H.; Sugiura, M. J. Am. Chem. Soc. 2003, 125, 2507.
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47
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35549009627
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Approximately 150 000 substances with a 5- or 6-membered ring N-aryl lactam core are listed in SciFinder (2006).
-
Approximately 150 000 substances with a 5- or 6-membered ring N-aryl lactam core are listed in SciFinder (2006).
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48
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Synthesis and Chemistry of Agrochemicals
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For recent results, see: a, ppp 18-29
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For recent results, see: (a) Mitchell, G.; Barnes, N.; Cox, J. M.; Mathews, I. R.; Parry, D. R.; Pearson, D. P. J.; Smith, S. C. Synthesis and Chemistry of Agrochemicals; ACS Symposium Series VI; American Chemical Society: Washington, DC, 2002; 800, ppp 18-29.
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