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Volumn 28, Issue 1-2, 2009, Pages 69-92

Neutralizing anti-influenza virus monoclonal antibodies: Therapeutics and tools for discovery

Author keywords

Antibody; Influenza virus; Memory B cell; Monoclonal

Indexed keywords

B LYMPHOCYTE RECEPTOR; HUMAN MONOCLONAL ANTIBODY; INFLUENZA VACCINE; NEUTRALIZING ANTIBODY; OKT 3; PALIVIZUMAB; VIRUS ANTIBODY;

EID: 60849088256     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.1080/08830180802593540     Document Type: Review
Times cited : (35)

References (69)
  • 2
    • 0042353731 scopus 로고    scopus 로고
    • The origin of the 1918 pandemic influenza virus: A continuing enigma
    • A.H. Reid and J.K. Taubenberger, The origin of the 1918 pandemic influenza virus: A continuing enigma J Gen Virol 84: 2285-2292, 2003.
    • (2003) J Gen Virol , vol.84 , pp. 2285-2292
    • Reid, A.H.1    Taubenberger, J.K.2
  • 3
    • 35548997439 scopus 로고    scopus 로고
    • Protective immunity and susceptibility to infectious diseases: Lessons from the 1918 influenza pandemic
    • R. Ahmed, M.B. Oldstone, and P. Palese, Protective immunity and susceptibility to infectious diseases: Lessons from the 1918 influenza pandemic. Nat Immunol 8: 1188-1193, 2003.
    • (2003) Nat Immunol , vol.8 , pp. 1188-1193
    • Ahmed, R.1    Oldstone, M.B.2    Palese, P.3
  • 4
    • 0029032565 scopus 로고
    • Return to the past: The case for antibody-based therapies in infectious diseases
    • A. Casadevall and M.D. Scharff, Return to the past: The case for antibody-based therapies in infectious diseases. Clin Infect Dis 21: 150-161, 1995.
    • (1995) Clin Infect Dis , vol.21 , pp. 150-161
    • Casadevall, A.1    Scharff, M.D.2
  • 5
    • 0026001916 scopus 로고
    • Historic aspects of intravenous immunoglobulin therapy
    • R.A. Good and E. Lorenz, Historic aspects of intravenous immunoglobulin therapy. Cancer 68: 1415-1421, 1991.
    • (1991) Cancer , vol.68 , pp. 1415-1421
    • Good, R.A.1    Lorenz, E.2
  • 6
    • 33750721332 scopus 로고    scopus 로고
    • Meta-analysis: Convalescent blood products for Spanish influenza pneumonia: A future H5N1 treatment?
    • T.C. Luke, E.M. Kilbane, J.L. Jackson, and S.L. Hoffman, Meta-analysis: Convalescent blood products for Spanish influenza pneumonia: A future H5N1 treatment? Ann Intern Med 145: 599-609, 2006.
    • (2006) Ann Intern Med , vol.145 , pp. 599-609
    • Luke, T.C.1    Kilbane, E.M.2    Jackson, J.L.3    Hoffman, S.L.4
  • 8
    • 34447301223 scopus 로고    scopus 로고
    • Role of the influenza virus nonstructural 1 protein in evasion of immunity
    • A. Fernandez-Sesma and T.M. Moran, Role of the influenza virus nonstructural 1 protein in evasion of immunity. Future Virol 2: 389-399, 2007.
    • (2007) Future Virol , vol.2 , pp. 389-399
    • Fernandez-Sesma, A.1    Moran, T.M.2
  • 10
    • 0034977654 scopus 로고    scopus 로고
    • The role of the antibody response in influenza virus infection
    • W. Gerhard, The role of the antibody response in influenza virus infection. Curr Top Microbiol Immunol 260: 171-190, 2001.
    • (2001) Curr Top Microbiol Immunol , vol.260 , pp. 171-190
    • Gerhard, W.1
  • 11
    • 0030722677 scopus 로고    scopus 로고
    • Role of the B-cell response in recovery of mice from primary influenza virus infection
    • W. Gerhard, K. Mozdzanowska, M. Furchner, G. Washko, and K. Maiese, Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol Rev 159: 95-103, 1997.
    • (1997) Immunol Rev , vol.159 , pp. 95-103
    • Gerhard, W.1    Mozdzanowska, K.2    Furchner, M.3    Washko, G.4    Maiese, K.5
  • 12
    • 39749195560 scopus 로고    scopus 로고
    • Evolution in miniature: Selection, survival, and distribution of antigen reactive cells in the germinal centre
    • D.M. Tarlinton, Evolution in miniature: Selection, survival, and distribution of antigen reactive cells in the germinal centre. Immunol Cell Biol 86: 133-138, 2008.
    • (2008) Immunol Cell Biol , vol.86 , pp. 133-138
    • Tarlinton, D.M.1
  • 13
    • 34249030028 scopus 로고    scopus 로고
    • Neutralization of animal virus infectivity by antibody
    • S.A. Reading and N.J. Dimmock, Neutralization of animal virus infectivity by antibody. Arch Virol 152: 1047-1059, 2007.
    • (2007) Arch Virol , vol.152 , pp. 1047-1059
    • Reading, S.A.1    Dimmock, N.J.2
  • 14
    • 0036441307 scopus 로고    scopus 로고
    • Mechanism of neutralization of influenza virus infectivity by antibodies
    • M. Knossow, M. Gaudier, A. Douglas, et al., Mechanism of neutralization of influenza virus infectivity by antibodies. Virology 302: 294-298, 2002.
    • (2002) Virology , vol.302 , pp. 294-298
    • Knossow, M.1    Gaudier, M.2    Douglas, A.3
  • 15
    • 0033079822 scopus 로고    scopus 로고
    • Treatment of influenza virus-infected SCID mice with nonneutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection
    • K. Mozdzanowska, K. Maiese, M. Furchner, and W. Gerhard, Treatment of influenza virus-infected SCID mice with nonneutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection. Virology 254: 138-146, 1999.
    • (1999) Virology , vol.254 , pp. 138-146
    • Mozdzanowska, K.1    Maiese, K.2    Furchner, M.3    Gerhard, W.4
  • 16
    • 0028965256 scopus 로고
    • Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice
    • G. Palladino, K. Mozdzanowska, G. Washko, and W. Gerhard, Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J Virol 69: 2075-2081, 1995.
    • (1995) J Virol , vol.69 , pp. 2075-2081
    • Palladino, G.1    Mozdzanowska, K.2    Washko, G.3    Gerhard, W.4
  • 17
    • 27644537524 scopus 로고    scopus 로고
    • Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy
    • M.M. Putz, I. Alberini, C.M. Midgley, I. Manini, E. Montomoli, and G.L. Smith, Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy. J Gen Virol 86: 2955-2960, 2005.
    • (2005) J Gen Virol , vol.86 , pp. 2955-2960
    • Putz, M.M.1    Alberini, I.2    Midgley, C.M.3    Manini, I.4    Montomoli, E.5    Smith, G.L.6
  • 18
    • 0242495755 scopus 로고    scopus 로고
    • Cutting edge: Long-term B cell memory in humans after smallpox vaccination
    • S. Crotty, P. Felgner, H. Davies, J. Glidewell, L. Villarreal, and R. Ahmed, Cutting edge: Long-term B cell memory in humans after smallpox vaccination. J Immunol 171: 4969-4973, 2003.
    • (2003) J Immunol , vol.171 , pp. 4969-4973
    • Crotty, S.1    Felgner, P.2    Davies, H.3    Glidewell, J.4    Villarreal, L.5    Ahmed, R.6
  • 19
    • 52949088297 scopus 로고    scopus 로고
    • Neutralizing antibodies derived from the B cells of 1918 pandemic survivors
    • X. Yu, Neutralizing antibodies derived from the B cells of 1918 pandemic survivors. Nature 455: 532-536, 2008.
    • (2008) Nature , vol.455 , pp. 532-536
    • Yu, X.1
  • 21
    • 1842405362 scopus 로고    scopus 로고
    • Lifetime of plasma cells in the bone marrow
    • R.A. Manz, A. Thiel, and A. Radbruch, Lifetime of plasma cells in the bone marrow. Nature 388: 133-134, 1997.
    • (1997) Nature , vol.388 , pp. 133-134
    • Manz, R.A.1    Thiel, A.2    Radbruch, A.3
  • 22
    • 0032033127 scopus 로고    scopus 로고
    • Humoral immunity due to long-lived plasma cells
    • M.K. Slifka, R. Antia, J.K. Whitmire, and R. Ahmed, Humoral immunity due to long-lived plasma cells. Immunity 8: 363-372, 1998.
    • (1998) Immunity , vol.8 , pp. 363-372
    • Slifka, M.K.1    Antia, R.2    Whitmire, J.K.3    Ahmed, R.4
  • 24
    • 0036235410 scopus 로고    scopus 로고
    • Plasma cells for a lifetime?
    • R.A. Manz and A. Radbruch, Plasma cells for a lifetime? Eur J Immunol 32: 923-927, 2002.
    • (2002) Eur J Immunol , vol.32 , pp. 923-927
    • Manz, R.A.1    Radbruch, A.2
  • 25
    • 0025732399 scopus 로고
    • Human in vivo-induced spontaneous IgG-secreting cells from tonsil, blood, and bone marrow exhibit different phenotype and functional level of maturation
    • J.A. Brieva, E. Roldan, M.L. De la Sen, and C. Rodriguez, Human in vivo-induced spontaneous IgG-secreting cells from tonsil, blood, and bone marrow exhibit different phenotype and functional level of maturation. Immunology 72: 580-583, 1991.
    • (1991) Immunology , vol.72 , pp. 580-583
    • Brieva, J.A.1    Roldan, E.2    De la Sen, M.L.3    Rodriguez, C.4
  • 26
    • 2942523585 scopus 로고    scopus 로고
    • Cellular niches controlling B lymphocyte behavior within bone marrow during development
    • K. Tokoyoda, T. Egawa, T. Sugiyama, B.I. Choi, and T. Nagasawa, Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20: 707-718, 2004.
    • (2004) Immunity , vol.20 , pp. 707-718
    • Tokoyoda, K.1    Egawa, T.2    Sugiyama, T.3    Choi, B.I.4    Nagasawa, T.5
  • 27
    • 0017137615 scopus 로고
    • The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin
    • W. Gerhard, The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin. J Exp Med 144: 985-995, 1976.
    • (1976) J Exp Med , vol.144 , pp. 985-995
    • Gerhard, W.1
  • 29
    • 67349177673 scopus 로고    scopus 로고
    • Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1)
    • World Health Organization, Geneva
    • World Health Organization. Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1). Reported to WHO, Geneva, 2008.
    • (2008) Reported to WHO
  • 30
    • 0020416123 scopus 로고
    • The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)
    • A.J. Caton, G.G. Brownlee, J.W. Yewdell, and W. Gerhard, The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 31: 417-427, 1982.
    • (1982) Cell , vol.31 , pp. 417-427
    • Caton, A.J.1    Brownlee, G.G.2    Yewdell, J.W.3    Gerhard, W.4
  • 31
    • 0021112689 scopus 로고
    • Antigenicity and evolution amongst recent influenza viruses of H1N1 subtype
    • F.L. Raymond, A.J. Caton, N.J. Cox, A.P. Kendal, and G.G. Brownlee, Antigenicity and evolution amongst recent influenza viruses of H1N1 subtype. Nucl Acids Res 11: 7191-7203, 1983.
    • (1983) Nucl Acids Res , vol.11 , pp. 7191-7203
    • Raymond, F.L.1    Caton, A.J.2    Cox, N.J.3    Kendal, A.P.4    Brownlee, G.G.5
  • 32
    • 0020629723 scopus 로고
    • Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: Multiple evolutionary pathways and sequential amino acid changes at key antigenic sites
    • G.W. Both, M.J. Sleigh, N.J. Cox, and A.P. Kendal, Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: Multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. J Virol 48: 52-60, 1983.
    • (1983) J Virol , vol.48 , pp. 52-60
    • Both, G.W.1    Sleigh, M.J.2    Cox, N.J.3    Kendal, A.P.4
  • 33
    • 0019432165 scopus 로고
    • Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
    • D.C. Wiley, I.A. Wilson, and J.J. Skehel, Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289: 373-378, 1981.
    • (1981) Nature , vol.289 , pp. 373-378
    • Wiley, D.C.1    Wilson, I.A.2    Skehel, J.J.3
  • 34
    • 37649029306 scopus 로고    scopus 로고
    • Immunoglobulin treatment for respiratory syncytial virus infection
    • CD004883
    • H. Fuller and C. Del Mar, Immunoglobulin treatment for respiratory syncytial virus infection. Cochrane Database Syst Rev CD004883, 2006.
    • (2006) Cochrane Database Syst Rev
    • Fuller, H.1    Del Mar, C.2
  • 35
    • 0034821759 scopus 로고    scopus 로고
    • Use of intravenous immunoglobulins for prophylaxis or treatment of infectious diseases
    • V.G. Hemming, Use of intravenous immunoglobulins for prophylaxis or treatment of infectious diseases. Clin Diagn Lab Immunol 8: 859-863, 2001.
    • (2001) Clin Diagn Lab Immunol , vol.8 , pp. 859-863
    • Hemming, V.G.1
  • 36
    • 36849087921 scopus 로고    scopus 로고
    • The growth and potential of human antiviral monoclonal antibody therapeutics
    • W.A. Marasco and J. Sui, The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol 25: 1421-1434, 2007.
    • (2007) Nat Biotechnol , vol.25 , pp. 1421-1434
    • Marasco, W.A.1    Sui, J.2
  • 37
    • 37549055446 scopus 로고    scopus 로고
    • Human monoclonal antibodies by immortalization of memory B cells
    • A. Lanzavecchia, D. Corti, and F. Sallusto, Human monoclonal antibodies by immortalization of memory B cells. Curr Opin Biotechnol 18: 523-528, 2007.
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 523-528
    • Lanzavecchia, A.1    Corti, D.2    Sallusto, F.3
  • 38
    • 43149109969 scopus 로고    scopus 로고
    • Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies
    • A.K. Kashyap, J. Steel, A.F. Oner, et al., Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies. Proc Natl Acad Sci USA 105: 5986-5991, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5986-5991
    • Kashyap, A.K.1    Steel, J.2    Oner, A.F.3
  • 39
    • 47049127117 scopus 로고    scopus 로고
    • Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses
    • C.F. Basler and P.V. Aguilar, Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses. Antiviral Res 79: 166-178, 2008.
    • (2008) Antiviral Res , vol.79 , pp. 166-178
    • Basler, C.F.1    Aguilar, P.V.2
  • 41
    • 38949120565 scopus 로고    scopus 로고
    • Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007
    • W.L. Wu, Y. Chen, P. Wang, et al., Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. J Virol 82: 1798-1807, 2008.
    • (2008) J Virol , vol.82 , pp. 1798-1807
    • Wu, W.L.1    Chen, Y.2    Wang, P.3
  • 42
    • 33745767275 scopus 로고    scopus 로고
    • Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus
    • M. Throsby, C. Geuijen, J. Goudsmit, et al., Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus. J Virol 80: 6982-6992, 2006.
    • (2006) J Virol , vol.80 , pp. 6982-6992
    • Throsby, M.1    Geuijen, C.2    Goudsmit, J.3
  • 43
    • 3042606257 scopus 로고    scopus 로고
    • Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets
    • J. ter Meulen, A.B. Bakker, E.N. van den Brink, et al., Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets. Lancet 363: 2139-2141, 2004.
    • (2004) Lancet , vol.363 , pp. 2139-2141
    • ter Meulen, J.1    Bakker, A.B.2    van den Brink, E.N.3
  • 44
    • 33746424849 scopus 로고    scopus 로고
    • Synergy and coverage of escape mutants
    • Human monoclonal antibody combination against SARS coronavirus
    • J. ter Meulen, E.N. van den Brink, L.L. Poon, et al., Human monoclonal antibody combination against SARS coronavirus: Synergy and coverage of escape mutants. PLoS Med 3: e237, 2006.
    • (2006) PLoS Med , vol.3
    • ter Meulen, J.1    van den Brink, E.N.2    Poon, L.L.3
  • 45
    • 33646024606 scopus 로고    scopus 로고
    • Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing
    • P.-J. Meijer, P.S. Andersen, M. Haahr Hansen, et al., Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J. Mol Biol 358: 764-772, 2006.
    • (2006) J. Mol Biol , vol.358 , pp. 764-772
    • Meijer, P.-J.1    Andersen, P.S.2    Haahr Hansen, M.3
  • 46
    • 38449104580 scopus 로고    scopus 로고
    • Humanization of antibodies
    • J.C. Almagro and J. Fransson, Humanization of antibodies. Front Biosci 13: 1619-1633, 2008.
    • (2008) Front Biosci , vol.13 , pp. 1619-1633
    • Almagro, J.C.1    Fransson, J.2
  • 49
    • 33750422851 scopus 로고    scopus 로고
    • Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice
    • B.J. Hanson, A.C. Boon, A.P. Lim, A. Webb, E.E. Ooi, and R.J. Webby, Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir Res 7: 126, 2006.
    • (2006) Respir Res , vol.7 , pp. 126
    • Hanson, B.J.1    Boon, A.C.2    Lim, A.P.3    Webb, A.4    Ooi, E.E.5    Webby, R.J.6
  • 50
    • 36349018925 scopus 로고    scopus 로고
    • Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies
    • N.V. Kaverin, I.A. Rudneva, E.A. Govorkova, et al., Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies. J Virol 81: 12911-12917, 2007.
    • (2007) J Virol , vol.81 , pp. 12911-12917
    • Kaverin, N.V.1    Rudneva, I.A.2    Govorkova, E.A.3
  • 51
    • 0019827545 scopus 로고
    • Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies
    • W. Gerhard, J. Yewdell, M.E. Frankel, and R. Webster, Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies. Nature 290: 713-717, 1981.
    • (1981) Nature , vol.290 , pp. 713-717
    • Gerhard, W.1    Yewdell, J.2    Frankel, M.E.3    Webster, R.4
  • 52
    • 0023082135 scopus 로고
    • The structure and function of the hemagglutinin membrane glycoprotein of influenza virus
    • D.C. Wiley and J.J. Skehel, The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem 56: 365-394, 1987.
    • (1987) Annu Rev Biochem , vol.56 , pp. 365-394
    • Wiley, D.C.1    Skehel, J.J.2
  • 53
    • 0346365299 scopus 로고    scopus 로고
    • Structural differences among hemagglutinins of influenza A virus subtypes are reflected in their antigenic architecture: Analysis of H9 escape mutants
    • N.V. Kaverin, I.A. Rudneva, N.A. Ilyushina, A.S. Lipatov, S. Krauss, and R.G. Webster, Structural differences among hemagglutinins of influenza A virus subtypes are reflected in their antigenic architecture: Analysis of H9 escape mutants. J Virol 78: 240-249, 2004.
    • (2004) J Virol , vol.78 , pp. 240-249
    • Kaverin, N.V.1    Rudneva, I.A.2    Ilyushina, N.A.3    Lipatov, A.S.4    Krauss, S.5    Webster, R.G.6
  • 54
    • 0036771639 scopus 로고    scopus 로고
    • Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants
    • N.V. Kaverin, I.A. Rudneva, N.A. Ilyushina, et al., Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants. J Gen Virol 83: 2497-2505, 2002.
    • (2002) J Gen Virol , vol.83 , pp. 2497-2505
    • Kaverin, N.V.1    Rudneva, I.A.2    Ilyushina, N.A.3
  • 55
    • 34047263014 scopus 로고    scopus 로고
    • Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse
    • M. Coughlin, G. Lou, O. Martinez, et al., Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse. Virology 361: 93-102, 2007.
    • (2007) Virology , vol.361 , pp. 93-102
    • Coughlin, M.1    Lou, G.2    Martinez, O.3
  • 56
    • 33947134318 scopus 로고    scopus 로고
    • Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates
    • S.E. Sloan, C. Hanlon, W. Weldon, et al., Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates. Vaccine 25: 2800-2810, 2007.
    • (2007) Vaccine , vol.25 , pp. 2800-2810
    • Sloan, S.E.1    Hanlon, C.2    Weldon, W.3
  • 57
    • 13444304336 scopus 로고    scopus 로고
    • Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice
    • T.C. Greenough, G.J. Babcock, A. Roberts, et al., Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J Infect Dis 191: 507-514, 2005.
    • (2005) J Infect Dis , vol.191 , pp. 507-514
    • Greenough, T.C.1    Babcock, G.J.2    Roberts, A.3
  • 58
    • 0036644329 scopus 로고    scopus 로고
    • Efficient isolation of novel human monoclonal antibodies with neutralizing activity against HIV-1 from transgenic mice expressing human Ig loci
    • Y. He, W.J. Honnen, C.P. Krachmarov, et al., Efficient isolation of novel human monoclonal antibodies with neutralizing activity against HIV-1 from transgenic mice expressing human Ig loci. J Immunol 169: 595-605, 2002.
    • (2002) J Immunol , vol.169 , pp. 595-605
    • He, Y.1    Honnen, W.J.2    Krachmarov, C.P.3
  • 59
    • 60849120618 scopus 로고    scopus 로고
    • World Health Organization. Cumulative Number of Reported Cases SARS
    • World Health Organization. Cumulative Number of Reported Cases (SARS).
  • 60
    • 60849134436 scopus 로고    scopus 로고
    • World Health Organization, Geneva
    • World Health Organization. Rabies Fact Sheet No. 99, 2006, Geneva.
    • (2006) Rabies Fact Sheet , Issue.99
  • 61
    • 4344651091 scopus 로고    scopus 로고
    • Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis) resistant mutants
    • J.P. DeVincenzo, C.B. Hall, D.W. Kimberlin, et al., Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis) resistant mutants. J Infect Dis 190: 975-978, 2004.
    • (2004) J Infect Dis , vol.190 , pp. 975-978
    • DeVincenzo, J.P.1    Hall, C.B.2    Kimberlin, D.W.3
  • 62
    • 35148851643 scopus 로고    scopus 로고
    • From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice
    • A. Jakobovits, R.G. Amado, X. Yang, L. Roskos, and G. Schwab, From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice. Nat Biotechnol 25: 1134-1143, 2007.
    • (2007) Nat Biotechnol , vol.25 , pp. 1134-1143
    • Jakobovits, A.1    Amado, R.G.2    Yang, X.3    Roskos, L.4    Schwab, G.5
  • 63
    • 44849091885 scopus 로고    scopus 로고
    • Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice
    • N. Nagata, N. Iwata, H. Hasegawa, et al., Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. Am J Pathol 172: 1625-1637, 2008.
    • (2008) Am J Pathol , vol.172 , pp. 1625-1637
    • Nagata, N.1    Iwata, N.2    Hasegawa, H.3
  • 64
    • 44449118948 scopus 로고    scopus 로고
    • Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    • J. Wrammert, K. Smith, J. Miller, et al., Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 453: 667-671, 2008.
    • (2008) Nature , vol.453 , pp. 667-671
    • Wrammert, J.1    Smith, K.2    Miller, J.3
  • 65
    • 34249669303 scopus 로고    scopus 로고
    • Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    • C.P. Simmons, N.L. Bernasconi, A.L. Suguitan, et al., Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med 4: e178, 2007.
    • (2007) PLoS Med , vol.4
    • Simmons, C.P.1    Bernasconi, N.L.2    Suguitan, A.L.3
  • 66
    • 33846200858 scopus 로고    scopus 로고
    • Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells
    • C. Tian, G.K. Luskin, K.M. Dischert, J.N. Higginbotham, B.E. Shepherd, and J.E. Crowe, Jr. Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells. Mol Immunol 44: 2173-2183, 2007.
    • (2007) Mol Immunol , vol.44 , pp. 2173-2183
    • Tian, C.1    Luskin, G.K.2    Dischert, K.M.3    Higginbotham, J.N.4    Shepherd, B.E.5    Crowe Jr., J.E.6
  • 67
    • 26444490055 scopus 로고    scopus 로고
    • Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    • T.M. Tumpey, C.F. Basler, P.V. Aguilar, et al., Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310: 77-80, 2005.
    • (2005) Science , vol.310 , pp. 77-80
    • Tumpey, T.M.1    Basler, C.F.2    Aguilar, P.V.3
  • 68
    • 1642352884 scopus 로고    scopus 로고
    • Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
    • J. Stevens, A.L. Corper, C.F. Basler, J.K. Taubenberger, P. Palese, and I.A. Wilson, Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science 303: 1866-1870, 2004.
    • (2004) Science , vol.303 , pp. 1866-1870
    • Stevens, J.1    Corper, A.L.2    Basler, C.F.3    Taubenberger, J.K.4    Palese, P.5    Wilson, I.A.6
  • 69
    • 12144288130 scopus 로고    scopus 로고
    • The structure and receptor binding properties of the 1918 influenza hemagglutinin
    • S.J. Gamblin, L.F. Haire, R.J. Russell, et al., The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science 303: 1838-1842, 2004.
    • (2004) Science , vol.303 , pp. 1838-1842
    • Gamblin, S.J.1    Haire, L.F.2    Russell, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.