Temporal quantitative proteomics by iTRAQ 2D-LC-MS/MS and corresponding mRNA expression analysis identify post-transcriptional modulation of actin-cytoskeleton regulators during TGF-β-Lnduced epithelial-mesenchymal transition

Journal of Proteome Research

Volumn 8, Issue 1, 2009, Pages 35-47

  Keshamouni, Venkateshwar G ^a   Jagtap, Pratik ^b   Michailidis, George ^c   Strahler, John R ^b   Kuick, Rork ^d   Reka, Ajaya Kumar ^a   Papoulias, Panagiotis ^b   Krishnapuram, Rashml ^a   Srirangam, Anjaiah ^a   Standiford, Theodore J ^a   Andrews, Philip C ^b   Omenn, Gilbert S ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Michigan Proteome Consortium   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Actin cytoskeleton remodeling; Beta actin; Calpain; Cofilin1; Epithelial mesenchymal transition; Ezrin; ITRAQ; Lung cancer; Moesin; Qualitative proteomics; TGF

Indexed keywords

ACTIN; BETA ACTIN; CALPAIN; CELL PROTEIN; COFILIN 1; FASCIN; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL HYBRIDIZATION; CELL LABELING; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSKELETON; DIFFERENTIAL DISPLAY; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENETIC STABILITY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MACROPHAGE MIGRATION; MASS SPECTROMETRY; MESENCHYME; MESENCHYME CELL; MOLECULAR HYBRIDIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA STABILITY; UPREGULATION; CELL DIFFERENTIATION; DRUG EFFECT; EPITHELIUM; GENE EXPRESSION REGULATION; MESODERM; METABOLISM; METHODOLOGY; RNA PROCESSING; TIME; TUMOR CELL LINE;

ACTINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; COFILIN 1; CYTOSKELETON; EPITHELIUM; GENE EXPRESSION REGULATION; HUMANS; MASS SPECTROMETRY; MESODERM; PROTEOMICS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 60849087975     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr8006478     Document Type: Article

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