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Volumn 6, Issue 1, 2009, Pages 65-75

Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum Sulphuricum 200

Author keywords

Anti carcinogenesis; Azo dye induced liver cancer; Geno and cyto toxicity biomarkers homeopathic remedy; Mice

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; HOMEOPATHIC AGENT; PHENOBARBITAL; SODIUM SULFURICUM; UNCLASSIFIED DRUG;

EID: 60749133798     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nem067     Document Type: Article
Times cited : (15)

References (51)
  • 1
    • 0141817894 scopus 로고    scopus 로고
    • The current position of complementary/alternative medicine in cancer
    • Ernst E. The current position of complementary/alternative medicine in cancer. Eur J Cancer 2003;39:2273-77.
    • (2003) Eur J Cancer , vol.39 , pp. 2273-2277
    • Ernst, E.1
  • 2
    • 32644449009 scopus 로고    scopus 로고
    • Complementary or alternative therapies for osteoarthritis
    • Earnst E. Complementary or alternative therapies for osteoarthritis. Nat Clin Pract Rheumatol 2006;2:74-80.
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 74-80
    • Earnst, E.1
  • 3
    • 33746056472 scopus 로고    scopus 로고
    • Use of complementary and alternative medicine in epilepsy
    • Ricotti V, Delanty N. Use of complementary and alternative medicine in epilepsy. Curr Neurol Neurosci Rep 2006;6:347-53.
    • (2006) Curr Neurol Neurosci Rep , vol.6 , pp. 347-353
    • Ricotti, V.1    Delanty, N.2
  • 4
    • 33645975208 scopus 로고    scopus 로고
    • Complementary medicine in chronic pain treatment
    • Simpson CA. Complementary medicine in chronic pain treatment. Phys Med Rehabil Clin N Am 2006;17:451-72.
    • (2006) Phys Med Rehabil Clin N Am , vol.17 , pp. 451-472
    • Simpson, C.A.1
  • 5
    • 0036968184 scopus 로고    scopus 로고
    • Complementary and alternative medicine: Opportunities and Challenges for cancer management and research
    • Richardson MA, Straus SE. Complementary and alternative medicine: Opportunities and Challenges for cancer management and research. Seminars in Oncology 2002;29:531-45.
    • (2002) Seminars in Oncology , vol.29 , pp. 531-545
    • Richardson, M.A.1    Straus, S.E.2
  • 6
    • 0037462673 scopus 로고    scopus 로고
    • The use of complementary and alternative medicine by cancer patients in New Zealand and regional cancer treatment center
    • Chrystal K, Allan S, Forgeson G, Issacs R. The use of complementary and alternative medicine by cancer patients in New Zealand and regional cancer treatment center. New Zealand Med J 2003;116:1-8.
    • (2003) New Zealand Med J , vol.116 , pp. 1-8
    • Chrystal, K.1    Allan, S.2    Forgeson, G.3    Issacs, R.4
  • 9
    • 32144434587 scopus 로고    scopus 로고
    • Complementary and alternative medicine use by patients with inflammatory bowel disease: Results from a postal survey
    • Bensoussan M, Jovenin N, Garcia B, Vandromme L, Jolly D, Bouche O, et al. Complementary and alternative medicine use by patients with inflammatory bowel disease: results from a postal survey. Gastroenterol Clin Biol 2006;30:14-23.
    • (2006) Gastroenterol Clin Biol , vol.30 , pp. 14-23
    • Bensoussan, M.1    Jovenin, N.2    Garcia, B.3    Vandromme, L.4    Jolly, D.5    Bouche, O.6
  • 10
    • 33847119383 scopus 로고    scopus 로고
    • Use of complementary and alternative medicine in Germany - a survey of patients with inflammatory bowel disease
    • doi: 10.1186/1472-6882-6-19
    • Joos S, Rosemann T, Szecsenyi J, Hahn EG, Willich SN, Brinkhaus B. Use of complementary and alternative medicine in Germany - a survey of patients with inflammatory bowel disease. BMC Complement Altern Med 2006;6:19. doi: 10.1186/1472-6882-6-19. http://www.biomedcentral.com/1472-6882/6/19.
    • (2006) BMC Complement Altern Med , vol.6 , pp. 19
    • Joos, S.1    Rosemann, T.2    Szecsenyi, J.3    Hahn, E.G.4    Willich, S.N.5    Brinkhaus, B.6
  • 11
    • 2442672276 scopus 로고    scopus 로고
    • Effect of a homeopathic drug, Chelidonium, in amelioration of p-Dab induced hepatocarcinogenesis in mice
    • Biswas SJ, Khuda-Bukhsh AR. Effect of a homeopathic drug, Chelidonium, in amelioration of p-Dab induced hepatocarcinogenesis in mice. BMC Complement Altern Med 2002;2:1-16.
    • (2002) BMC Complement Altern Med , vol.2 , pp. 1-16
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 12
    • 3042805454 scopus 로고    scopus 로고
    • Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in mice
    • Biswas SJ, Khuda-Bukhsh AR. Evaluation of protective potentials of a potentized homeopathic drug, Chelidonium majus, during azo dye induced hepatocarcinogenesis in mice. Indian J Exp Biol 2004;42:698-714.
    • (2004) Indian J Exp Biol , vol.42 , pp. 698-714
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 13
    • 28444450816 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug, Carcinosin-200, fed alone and in combination with another drug, Chelidonium-200, in amelioration of p-Dab induced hepatocarcinogenesis in mice
    • Biswas SJ, Pathak S, Bhattacharjee N, Das JK, Khuda-Bukhsh AR. Efficacy of a potentized homeopathic drug, Carcinosin-200, fed alone and in combination with another drug, Chelidonium-200, in amelioration of p-Dab induced hepatocarcinogenesis in mice. J Altern Complement Med 2005;11:839-54.
    • (2005) J Altern Complement Med , vol.11 , pp. 839-854
    • Biswas, S.J.1    Pathak, S.2    Bhattacharjee, N.3    Das, J.K.4    Khuda-Bukhsh, A.R.5
  • 14
    • 33646191834 scopus 로고    scopus 로고
    • Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice
    • Pathak S, Das JK, Biswas SJ, Khuda-Bukhsh AR. Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice. Mol Cell Biochem 2006;258:121-31.
    • (2006) Mol Cell Biochem , vol.258 , pp. 121-131
    • Pathak, S.1    Das, J.K.2    Biswas, S.J.3    Khuda-Bukhsh, A.R.4
  • 15
    • 84883833956 scopus 로고
    • Cellular populations and mitotic activity in rat liver parenchyma during azo dye carcinogenesis
    • Daust R, Molnar F. Cellular populations and mitotic activity in rat liver parenchyma during azo dye carcinogenesis. Cancer Res 1964;24:1898-1909.
    • (1964) Cancer Res , vol.24 , pp. 1898-1909
    • Daust, R.1    Molnar, F.2
  • 16
    • 0003595535 scopus 로고
    • On the evaluation of carcinogenic risk of chemicals to man
    • IARC International Agency for Research on Cancer
    • IARC (International Agency for Research on Cancer). On the evaluation of carcinogenic risk of chemicals to man. Group-2B 1987;7:449.
    • (1987) Group-2B , vol.7 , pp. 449
  • 17
    • 0035116205 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene
    • Ohnishi S, Murata M, Degawa M, Kawanishi S. Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene. Jpn J Cancer Res 2001;92:23-9.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 23-29
    • Ohnishi, S.1    Murata, M.2    Degawa, M.3    Kawanishi, S.4
  • 18
    • 28844435330 scopus 로고    scopus 로고
    • Species-specific effects of the hepatocarcinogens 3′- methyl-4-dimehylaminoazobenzene and ortho-aminoazotoluene in mouse and rat liver
    • Merkulova TI, Kropachev KY, Timofeeva OA, Vasiliev GV, Levashova ZB, Ilnitskaya SI, et al. Species-specific effects of the hepatocarcinogens 3′- methyl-4-dimehylaminoazobenzene and ortho-aminoazotoluene in mouse and rat liver. Mol Carcinog 2005;44:223-32.
    • (2005) Mol Carcinog , vol.44 , pp. 223-232
    • Merkulova, T.I.1    Kropachev, K.Y.2    Timofeeva, O.A.3    Vasiliev, G.V.4    Levashova, Z.B.5    Ilnitskaya, S.I.6
  • 19
    • 27144502020 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic effects of the azo-dye p-dimethylaminoazobenzene in mice: A time-course study
    • Biswas SJ, Khuda-Bukhsh AR. Cytotoxic and genotoxic effects of the azo-dye p-dimethylaminoazobenzene in mice: A time-course study. Mutat Res 2005;587:1-8.
    • (2005) Mutat Res , vol.587 , pp. 1-8
    • Biswas, S.J.1    Khuda-Bukhsh, A.R.2
  • 21
    • 60749129670 scopus 로고    scopus 로고
    • NTP. Report on Carcinogens. (11th edn). Research Triangle Park, NC: National Toxicology Program. 2005 (Retrieved from http://ntp.niehs.nih. gov/index.cfm?Objectid=32BA9724-F1F6-975E-7FCE50709CB4C932.).
    • NTP. Report on Carcinogens. (11th edn). Research Triangle Park, NC: National Toxicology Program. 2005 (Retrieved from http://ntp.niehs.nih. gov/index.cfm?Objectid=32BA9724-F1F6-975E-7FCE50709CB4C932.).
  • 22
    • 29544433631 scopus 로고    scopus 로고
    • Phenobarbital and Sodium salt
    • IARC International Agency for Research on Cancer
    • IARC (International Agency for Research on Cancer). Phenobarbital and Sodium salt. IARC monograph 2001;79:161.
    • (2001) IARC monograph , vol.79 , pp. 161
  • 23
    • 0018406229 scopus 로고
    • Anticonvulsant drugs and cancer, A cohort study in patients with severe epilepsy
    • White SJ, McLean AEM, Howland C. Anticonvulsant drugs and cancer, A cohort study in patients with severe epilepsy. Lancet 1979;ii:458-61.
    • (1979) Lancet , vol.2 , pp. 458-461
    • White, S.J.1    McLean, A.E.M.2    Howland, C.3
  • 24
    • 0034117990 scopus 로고    scopus 로고
    • Paradoxical effects of phenobarbital on mouse carcinogenesis
    • Lee GH. Paradoxical effects of phenobarbital on mouse carcinogenesis. Toxicol Pathol 2000;28:215-25.
    • (2000) Toxicol Pathol , vol.28 , pp. 215-225
    • Lee, G.H.1
  • 25
    • 0042889217 scopus 로고    scopus 로고
    • Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression
    • Kinoshita A, Wanibuchi H, Morimura K, Wei M, Shen J, Imaoka S, et al. Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis 2003;24:1389-99.
    • (2003) Carcinogenesis , vol.24 , pp. 1389-1399
    • Kinoshita, A.1    Wanibuchi, H.2    Morimura, K.3    Wei, M.4    Shen, J.5    Imaoka, S.6
  • 26
    • 8644283540 scopus 로고    scopus 로고
    • Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug Phenobarbital, in mice: A time course study
    • Biswas SJ, Pathak S, Khuda-Bukhsh AR. Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug Phenobarbital, in mice: A time course study. Mutat Res 2004;563:1-11.
    • (2004) Mutat Res , vol.563 , pp. 1-11
    • Biswas, S.J.1    Pathak, S.2    Khuda-Bukhsh, A.R.3
  • 27
    • 0013902563 scopus 로고
    • Studies on the hepatocyte in azo dye carcinogenesis
    • Palekar SD, Sirsat SM. Studies on the hepatocyte in azo dye carcinogenesis. Indian J Exp Boil 1966;4:73-8.
    • (1966) Indian J Exp Boil , vol.4 , pp. 73-78
    • Palekar, S.D.1    Sirsat, S.M.2
  • 29
    • 0018117024 scopus 로고
    • Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3′-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine
    • Kitagawa T, Sugano H. Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3′-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine. Gann 1978;69:679-87.
    • (1978) Gann , vol.69 , pp. 679-687
    • Kitagawa, T.1    Sugano, H.2
  • 30
    • 0017373204 scopus 로고
    • Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats
    • Kitagawa T, Sugano H. Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats. Gann 1977;68:255-6.
    • (1977) Gann , vol.68 , pp. 255-256
    • Kitagawa, T.1    Sugano, H.2
  • 31
    • 0142243234 scopus 로고    scopus 로고
    • Towards understanding molecular mechanisms of action of homeopathic drugs: An overview
    • Khuda-Bukhsh AR. Towards understanding molecular mechanisms of action of homeopathic drugs: An overview. Mol Cell Biochem 2003;253:339-45.
    • (2003) Mol Cell Biochem , vol.253 , pp. 339-345
    • Khuda-Bukhsh, A.R.1
  • 32
    • 33750861301 scopus 로고    scopus 로고
    • Laboratory research in homeopathy: Pro
    • Khuda-Bukhsh AR. Laboratory research in homeopathy: pro. Integr Cancer Ther 2006;5:320-32.
    • (2006) Integr Cancer Ther , vol.5 , pp. 320-332
    • Khuda-Bukhsh, A.R.1
  • 33
    • 60749101106 scopus 로고
    • Homeopathic Pharmacopoeia of India. Ministry of Health
    • Controller of Publications
    • Homeopathic Pharmacopoeia of India. Ministry of Health. Government of India Press, Coimbatore-641019: Controller of Publications, 1971;1:165.
    • (1971) Government of India Press, Coimbatore-641019 , vol.1 , pp. 165
  • 34
    • 60749102268 scopus 로고    scopus 로고
    • Supportive evidences for anticancerous potential of an alternative medicine in hepatocarcinogenesis of mice
    • June, DOI:10.1159/000102007
    • Pathak S, Bhattacharjee N, Das JK, Chaki Chowdhury S, Roy Karmakar S, Banerjee P et al. Supportive evidences for anticancerous potential of an alternative medicine in hepatocarcinogenesis of mice. Res Com Med. June issue, 2007; 14:132 (DOI:10.1159/000102007).
    • Res Com Med , vol.14 , Issue.2007 , pp. 132
    • Pathak, S.1    Bhattacharjee, N.2    Das, J.K.3    Chaki Chowdhury, S.4    Roy Karmakar, S.5    Banerjee, P.6
  • 36
    • 17044431887 scopus 로고    scopus 로고
    • Transcriptional profiling on chromosome 19p indicated frequent down regulation of ACP5 expression in hepatocellular carcinoma
    • Chan KY, Wong N, Lai PB, Squire JA, Macgregor PF, Behesthi B, et al. Transcriptional profiling on chromosome 19p indicated frequent down regulation of ACP5 expression in hepatocellular carcinoma. Int J cance 2005;114:902-8.
    • (2005) Int J cance , vol.114 , pp. 902-908
    • Chan, K.Y.1    Wong, N.2    Lai, P.B.3    Squire, J.A.4    Macgregor, P.F.5    Behesthi, B.6
  • 37
    • 0024235620 scopus 로고
    • Clinical use of serum enzymes in liver diseases
    • Reichling JJ, Kaplan MM. Clinical use of serum enzymes in liver diseases. Dig Dis Sci 1988;33:1601-14.
    • (1988) Dig Dis Sci , vol.33 , pp. 1601-1614
    • Reichling, J.J.1    Kaplan, M.M.2
  • 38
    • 3042852857 scopus 로고    scopus 로고
    • High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients
    • retrieved from
    • Wiwanitkit V. High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients. BMC Family Practice 2001; 2:2 (retrieved from http://www.biomedcentral.com/1471-2296/2/2).
    • (2001) BMC Family Practice , vol.2 , pp. 2
    • Wiwanitkit, V.1
  • 39
    • 0033535371 scopus 로고    scopus 로고
    • Lipid peroxidation-DNA damage by malondialdehyde
    • Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 1999;424:83-95.
    • (1999) Mutat Res , vol.424 , pp. 83-95
    • Marnett, L.J.1
  • 40
    • 1342301740 scopus 로고    scopus 로고
    • Studies of biochemical parameters in breast cancer with and without metastasis
    • Mishra S, Sharma DC, Sharma P. Studies of biochemical parameters in breast cancer with and without metastasis. Indian J Clin Biochem 2004;19:71-5.
    • (2004) Indian J Clin Biochem , vol.19 , pp. 71-75
    • Mishra, S.1    Sharma, D.C.2    Sharma, P.3
  • 41
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher D, Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer 1996;32A:30-8.
    • (1996) Eur J Cancer , vol.32 A , pp. 30-38
    • Dreher, D.1    Junod, A.F.2
  • 42
    • 18544392795 scopus 로고    scopus 로고
    • Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma
    • Jungst C, Cheng B, Gehrke R, Schmitz V, Nischalke HD, Ramakers J, et al. Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma. Hepatology 2004;39:1663-72.
    • (2004) Hepatology , vol.39 , pp. 1663-1672
    • Jungst, C.1    Cheng, B.2    Gehrke, R.3    Schmitz, V.4    Nischalke, H.D.5    Ramakers, J.6
  • 43
    • 14844323676 scopus 로고    scopus 로고
    • Effect of alcohol on viral hepatitis and other forms of liver dysfunction
    • Balasubramanian S, Kowdley KV. Effect of alcohol on viral hepatitis and other forms of liver dysfunction. Clin Liver Dis 2005;9:83-101.
    • (2005) Clin Liver Dis , vol.9 , pp. 83-101
    • Balasubramanian, S.1    Kowdley, K.V.2
  • 44
    • 33645236156 scopus 로고    scopus 로고
    • Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma
    • Czeczot H, Scibior D, Skrzycki M, Podsiad M. Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma. Acta Biochem Pol 2006;53:237-42.
    • (2006) Acta Biochem Pol , vol.53 , pp. 237-242
    • Czeczot, H.1    Scibior, D.2    Skrzycki, M.3    Podsiad, M.4
  • 47
    • 33745684501 scopus 로고    scopus 로고
    • Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the Interactions of Botanical Extract Combinations Against the Viability of Prostate Cancer Cell Lines. eCAM 2006;3:117-24.
    • Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the Interactions of Botanical Extract Combinations Against the Viability of Prostate Cancer Cell Lines. eCAM 2006;3:117-24.
  • 49
    • 24344490294 scopus 로고    scopus 로고
    • Echinacea: A Miracle Herb against Aging and Cancer? Evidence In vivo in Mice
    • Miller SC. Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice. Evid Based Compliment Alternat Med 2005;2:309-14.
    • (2005) Evid Based Compliment Alternat Med , vol.2 , pp. 309-314
    • Miller, S.C.1
  • 50
    • 3042606421 scopus 로고    scopus 로고
    • Ruta 6 selectively induced cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer
    • Pathak S, Multani AS, Banerjee P. Ruta 6 selectively induced cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol 2003;23:975-82.
    • (2003) Int J Oncol , vol.23 , pp. 975-982
    • Pathak, S.1    Multani, A.S.2    Banerjee, P.3
  • 51
    • 0030970288 scopus 로고    scopus 로고
    • Potentized homeopathic drugs act through regulation of gene expression: A hypothesis to explain their mechanism and pathways of action in vivo
    • Khuda-Bukhsh AR. Potentized homeopathic drugs act through regulation of gene expression: a hypothesis to explain their mechanism and pathways of action in vivo. Com Ther Med 1997;5:13-46.
    • (1997) Com Ther Med , vol.5 , pp. 13-46
    • Khuda-Bukhsh, A.R.1


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