Effect of homeopathic drug, Chelidonium, an amelioration of p-DAB induced hepatocarcinogenesis in mice

BMC Complementary and Alternative Medicine

Volumn 2, Issue , 2002, Pages

  Biswas, Surjyo Jyoti ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; CHELIDONIUM EXTRACT; HOMEOPATHIC AGENT; PHENOBARBITAL; ACID PHOSPHATASE; ALKALINE PHOSPHATASE; CARCINOGEN; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHELIDONIUM; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; GENOTOXICITY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER NODULE; MOUSE; NONHUMAN; STATISTICAL SIGNIFICANCE; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; HOMEOPATHY; LIPID PEROXIDATION; LIVER TUMOR; METABOLISM; MICRONUCLEUS TEST; MITOSIS INDEX; PATHOLOGY; PHYTOTHERAPY; REMISSION;

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ANIMALS; CARCINOGENS; CHELIDONIUM; HOMEOPATHY; LIPID PEROXIDATION; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICRONUCLEUS TESTS; MITOTIC INDEX; P-DIMETHYLAMINOAZOBENZENE; PHYTOTHERAPY; PLANT EXTRACTS; REMISSION INDUCTION;

EID: 2442672276     PISSN: 14726882     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6882-2-4     Document Type: Article

References (34)

1. Kery RY, Horvath J, Nasz I, Verzar-Petri G, Kulcsar G, Dan P: Antiviral alkaloid in Chelidonium majus L. Acta Pharm Hung 1987, 57:19-25
2. Lenfeld J, Kroutil M, Marsalek E, Slavik J, Preininger V, Simanek V: Antiinflammatory activity of quatertnary benzophenanthridine alkaloids from Chelidonium majus. Planta Med 1981, 43:161-165
3. Colombo ML, Bosisio E: Pharmacological activities of Chelidonium majus L. Pharmacol Res 1996, 33:127-134
4. Vavreckova C, Gawlik I, Muller K: Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non redox mehanism. Planta Med 1996, 62:397-401
5. Vahlensieck U, Hahn R, Winterhoff H, Gumbinger HG, Nahrstedt A, Kemper Fh: The effect of Chelidonium majus herb extract on choleresis in the isolated perfused rat liver. Planta Med 1995, 61:267-271
6. Boericke W: Pocket Manual of Homeopathic Meteria Medica, Indian Edition Calcutta: Sett Dey and Co, 1976
7. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with Folin-Phenol reagent. J Biol Chem 1951, 193:265-275
8. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 1984, 105:302-310
9. Walter K, Schutt C: Acid and alkaline phosphatase in serum (two point method In Methods in Enzymatic Analysis 1974, 2:
10. Daoust R, Molnar F: Cellular populations and mitotic activity in rat liver parenchyma during azo dye carcinogenesis. Cancer Res 1964, 24:1898-1909
11. Samuels AR, Bhargava M, Levine WG: Uptake of hepatobiliary fate of two hepatocarcinogens, N,N-dimethyl-4-aminoazobenzene and 3"-methyl-N,N-dimrthyl-4-aminoazobenzene, in rat. Cancer Res 1983, 43:4816-4821
12. Kitagawa T, Sugano H: Enhancement of azodye hepatocarcinogenesis with dietary phenobarbital in rats. Gann 1977, 68:255-256
13. Ohnishi S, Murata M, Degawa M, Kawanishi S: Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene. Jpn. J. Cancer Res. 2001, 92(1):23-29
14. Roberfroid M, de Gerlache J, Lans M: Action of Hahnemanian potencies upon artificially produced cancer in animals. In: Aspects of research in Homeopathy 1983, 1:
15. Fisher P: Cancer and the mithridates effect. Proc. First. Intl. Congress of Medicine in Europe. 1992, 1:7-8
16. Plaa GL, Amdun AM, Doull J, Klasser CD: Toxic responses of the liver. Pergamon Press 1991
17. Comporti M: Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest 1985, 53:599-623
18. Deboyser D, Goethals F, Krack G, Robertroid M: Investigation into the mechanism of tetracycline induced steatosis study in isolated hepatocytes. Toxicol and Appl Pharmacol 1989, 97:473-479
19. Hirano T, Higashi K, Sakai A, Tsurudome Y, Ootsuyama Y, Kido R, Kasai H: Analyses of oxidative DNA damage and its repair activity in the livers of 3"-methyl-4-dimethylaminoazobenzene-treated rodents. Jpn. J. Cancer Res 2000, 91:681-685
20. Linde K, Jonas WB, Melchart D, Worku F, Wagner H, Eitel F: Critical review and meta-analysis of serial agitated dilutions in experimental toxicology. Hum exp Toxicol 1994, 13:481
21. Datta S, Mallick P, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenic Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice:II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses. Comp Ther Med 1999, 7:156-163
22. Chakrabarti J, Biswas SJ, Khuda-Bukhsh AR: Cytogenetical efficacies of ultrasound in mice and their modulations by Actinomycin D and a homeopathic drug, Arnica-30. Indian J Exp Biol 2001, 39:1235-1242
23. Khuda-Bukhsh AR: Potentized homeopathic drugs act through regulation of gene expression: a hypothesis to explain their mechanism and pathways of action in vivo. Com Ther Med 1997, 5:43-46
24. Khuda Bukhsh AR, Maity S: Alteration of cytogenetical effects by oral administration of a homeopathic drug, Ruta Graveolens in mice exposed to sub lethal X-irradiation. The Berlin J Res Hom. 1991, 1:264-274
25. Banik S, Khuda Bukhsh AR: Alteration of cytogenetical and haematological effects of ultra-low doses of Ginseng in whole body X-irradiated mice. Nucleus 1996, 49:28-35
26. Datta S, Mallick P, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenic Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice:II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses. Com Ther Med 1999, 7:156-163
27. Kundu SN, Mitra K, Khuda Bukhsh AR: Efficacy of potentized homeopathic drug (Arsenicum-Album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice:IV. Pathological changes, protein profiles, and content of DNA and RNA. Com Ther Med 2000, 8:157-165
28. Datta S, Mallick P, Khuda Bukhsh AR: Comparative efficacy of two microdoses of a potentized homeopathic drug, Cadmium Sulphoricum, in reducing cytogenetical effects produced by cadmium chloride in mice: A time-course study. BMC Compl & Alter Med 2001, 1:9
29. Khuda-Bukhsh AR: The efficacy of potentized homeopathic drug in combating arsenic poisoning. Pers. Cytol. Genet 2001, 10:231-239
30. Datta S, Khuda Bukhsh AR: Efficacy of potentised homeopathic drug, Stannum-30, in modifying clastogenic effects of stannous chloride in mice. Pers Cytol Genet 1998, 9:345-351
31. Datta S, Mallick P, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenic Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: Comparative studies of pre-, post- and combined pre-and post-oral administration and comparative efficacy of two microdoses. Comp. Ther Med, 1999, 7:62
32. Kundu SN, Mitra K, Khuda-Bukhsh AR: Efficacy of a potentized III Efficacy of potentized homeopathic drug (Arsenic Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: III Enzymatic changes and recovery of tissue damage in liver. Comp Ther Med, 2000, 8:76-81
33. Kundu SN, Mitra K, Khuda Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenicum-Album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles, and content of DNA and RNA. Com Ther Med 2000, 8:157-165
34. Gardner EJ, Simmons MJ, Snustad DP: Principles of Genetics, John Wiley & Sons, N.Y. 1991