Developmental toxicity and toxicokinetics of two endothelin receptor antagonists in rats and rabbits

Teratology

Volumn 59, Issue 1, 1999, Pages 51-59

  Treinen, K A ^a   Louden, C ^a   Dennis, M J ^a   Wier, P J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; ENDOTHELIN RECEPTOR ANTAGONIST; ENRASENTAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONGENITAL BLOOD VESSEL MALFORMATION; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EMBRYO; FEMALE; FOOD INTAKE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RABBIT; RAT; TERATOGENESIS; THYROID DISEASE; TOXICITY TESTING; TOXICOKINETICS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; AREA UNDER CURVE; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETUS; INDANS; MALE; PREGNANCY; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ENDOTHELIN; TERATOGENS;

EID: 0033028390     PISSN: 00403709     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9926(199901)59:1<51::AID-TERA10>3.0.CO;2-I     Document Type: Article

References (34)

1. Agresti A. 1990. Categorical data analysis. New York: John Wiley & Sons. p 59-66, 100-102.
2. Barni T, Maggi M, Fantoni G, Serio M, Tollaro I, Gloria L. Vannelli GB. 1995. Identification and localization of endothelin-1 and its receptors in human fetal jaws. Dev Biol 169:373-377.
3. Bockman DE, Redmond ME, Waldo K, Davis H, Kirby ML. 1987. Effect of neural crest ablation on development of the heart and arch arteries in the chick. Am J Anat 80:332-341.
4. Brand M, Le Moullec J-M, Corvol R, Gasc J-M. 1998. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo. J Clin Invest 101:549-559.
5. Chan TSK, Feng CX, Chan WY, Chung SSM, Chung SK. 1995. Mouse preproendothelin-1 gene cDNA cloning, sequence analysis and determination of sites of expression during embryonic development. Eur J Biochem 234:819-826.
6. Conover WJ. 1980. Practical nonparametric statistics. New York: John Wiley & Sons. p 230-234.
7. Douglas SA. 1997. Clinical development of endothelin receptor antagonists. Trends Pharmacol Sci 18:408-412.
8. Douglas SA, Louden C, Vickery-Clarke LM, Storer BL, Hart T, Feurerstein GZ, Elliott JD, Ohlstein EH. 1994. A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Circ Res 75:190-197.
9. Dubin D, Pratt RE, Cooke JP, Dzau VJ. 1989. Endothelin, a potent vasoconstrictor, is a vascular smooth muscle mitogen. J Vasc Med Biol 1:150-154.
10. Kirby ML. 1993. Cellular and molecular contributions of the cardiac neural crest to cardiovascular development. Trends Cardiovasc Med 3:18-23.
11. Komura I, Kurihara H, Sugiyama T, Takafu F, Yazaki Y. 1988. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett 238:249-252.
12. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T. Wei-Hua C, Kamada N, Jishage K, Ouchi Y, Azuma S, Toyoda Y, Ishikawa T, Kumada M, Yazaki Y. 1994. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature 368:703-710.
13. Kurihara Y, Kurihara H, Oda H, Maemura K, Hagai R, Ishikawa T, Yazaki Y. 1995a. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 96:293-300.
14. Kurihara Y, Kurihara H, Maemura K, Kuwaki T, Kumada M, Yazaki Y. 1995b. Impaired development of the thyroid and thymus in endothelin-1 knockout mice. J Cardiovasc Pharmacol 26:13-16.
15. Lehrer SB, Hui JY, Wills M, Keller KA. 1997. Specific teratogenic effects of an endothelin receptor antagonist in rats and rabbits. Teratology 55:42.
16. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. 1996. SAS system for mixed models. Cary, NC: SAS Institute.
17. McKenzie J. 1966. The first arch syndrome. Dev Med Child Neurol 8:55-66.
18. Miller RG Jr. 1981. Simultaneous statistical inference. New York: Springer Verlag.
19. Nishibatake M, Kirby ML, Van Mierop LH. 1987. Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation. Circulation 75:255-264.
20. Noden DM. 1986. Origins and patterning of craniofacial mesenchymal tissues. J Craniofac Genet Dev Biol [Suppl] 2:15-31.
21. Noden DM. 1991. Cell movements and control of patterned tissue assembly during craniofacial development. J Craniofac Genet Dev Biol 11:192-213.
22. Ohlstein EH, Nambi P, Lago A, Hay DWP, Beck G, Fong KL, Eddy EP, Smith P, Ellens H, Elliott JD. 1996. Nonpeptide endothelin receptor antagonists VI: pharmacological characterization of SB-217242, a potent highly bioavailable nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 276:609-615.
23. Power RF, Wharton J, Zhao Y, Bloom SR, Polak JM. 1989. Autoradiographic localization of endothelin-1 binding sites in the human cardiovascular and respiratory systems. J Cardiovasc Pharmacol 13:50-56.
24. SAS Institute, Inc. 1990. SAS procedures. Version 6, 3rd ed. Cary, NC: SAS Institute.
25. SAS Institute, Inc. 1992. SAS technical report P-229. SAS/STAT software: Changes and enhancements, release 6.07. Cary, NC: SAS Institute, p 369-406.
26. Scamber PJ, Kelly D, Lindsay E, Williamson R, Goldberg R, Shprintzen R, Wilson DI, Goodship JA, Cross IE, Burn J. 1992. Velo-cardiofacial syndrome associated with chromosome 22 deletion encompassing the DiGeorge locus. Lancet 339:1138-1139.
27. Solomon HM, Wier PJ, Fish CJ, Hart TK, Johnson CM, Posobiec LM, Gowan CC, Maleeff BE, Kerns WD. 1997. Spontaneous and induced alterations in the cardiac membranous ventricular septum of fetal, weanling, and adult rats. Teratology 55:185-194.
28. Staples RE. 1974. Detection of visceral alterations in mammalian fetuses. Teratology 9:37.
29. Van Mierop LH, Kutsche LM. 1986. Cardiovascular anomalies in DiGeorge syndrome and importance of neural crest as a possible pathogenetic factor. Am J Cardiol 8:133-137.
30. Warner TD, Elliott JD, Ohlstein EH, 1996. California dreamin' 'bout endothelin: Emerging new therapies. Trends Pharmacol Sci 17:177-181.
31. Wharton J, Rutherford RAD, Gordon L, Moscoso G, Schiemberg I, Gaer JAR, Taylor KM, Polak JM. 1991. Localization of endothelin binding sites and endothelin-like immunoreactivity in human fetal heart. J Cardiovasc Pharmacol 17:378-384.
32. Wilson DI, Cross IE, Goodship JA, Coulthard S, Carey AH, Scambler PJ, Bain HH, Hunter AS, Carter PE, Burn J. 1991. DiGeorge syndrome with isolated aortic coarctation and isolated ventricular septal defect in three sibs with a 22q11 deletion of maternal origin. Br Heart J 66:308-312.
33. Wilson DI, Goodship JA, Burn J, Cross IE, Scambler PJ. 1992. Deletion within chromosome 22q11 in familial congenital heart disease. Lancet 340:573-575.
34. Wilson JG. 1965. Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, Warkany J, editors. Teratology: Principles and techniques. Chicago: University of Chicago Press, p 262-277.