Effects of tributyltin (TBT) on in vitro hormonal and biotransformation responses in Atlantic salmon (Salmo salar)

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 72, Issue 3-4, 2009, Pages 209-218

  Mortensen, Anne S ^a   Arukwe, Augustine ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ISOPROTEIN; TRIBUTYLTIN; DISINFECTANT AGENT; MESSENGER RNA; ORGANOTIN COMPOUND; STEROID RECEPTOR; VITELLOGENIN;

AHR2 GENE; AHRR GENE; ANIMAL CELL; ARBETA GENE; ARNT GENE; ARTICLE; ATLANTIC SALMON; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYP1A1 GENE; CYP3A GENE; ENZYME ACTIVITY; ENZYME ASSAY; ERALPHA GENE; ERBETA GENE; GENE; GENE EXPRESSION; HORMONE RESPONSE; IN VITRO STUDY; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VTG GENE; ANIMAL; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GENETICS; LIVER; METABOLISM; PHYSIOLOGY; WATER POLLUTANT;

SALMO SALAR; SALMONIDAE;

ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DISINFECTANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HEPATOCYTES; LIVER; RECEPTORS, STEROID; RNA, MESSENGER; SALMO SALAR; SIGNAL TRANSDUCTION; TRIALKYLTIN COMPOUNDS; VITELLOGENINS; WATER POLLUTANTS, CHEMICAL;

EID: 60749101471     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390802539061     Document Type: Article

References (51)

1. Afonso, L. O., Wassermann, G. J., and Terezinha de Oliveira, R. 2001. Sex reversal in Nile tilapia (Oreochromis niloticus) using a nonsteroidal aromatase inhibitor. J. Exp. Zool. 290:177-181.
2. Arukwe, A. 2006. Toxicological housekeeping genes: Do they really keep the house? Environ. Sci. Technol. 40:7944-7949.
3. Arukwe, A., and Goksoyr, A. 1997. Changes in three hepatic cytochrome P450 subfamilies during a reproductive cycle in turbot (Scophthalmus maximus L.). J. Exp. Zool. 277:313-325.
4. Arukwe, A., Yadetie, F., Male, R., and Goksoyr, A. 2001. In vivo modulation of nonylphenol-induced zonagenesis and vitellogenesis by the antiestrogen, 3,3′4,4′-tetrachlorobiphenyl (PCB-77) in juvenile fish. Environ. Toxicol. Pharmacol. 10:5-15.
5. Babler, S. J. M. 1970. The occurence of a penis-like outgrowth behind the right tentacle in spent female of Nucella lapillus (L.). Proc. Malacol. Soc. Lond. 39:231-233.
6. Bard, S. M. 2000. Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms. Aquat. Toxicol. 48:357-389.
7. Bemanian, V., Male, R., and Goksoyr, A. 2004. The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERalpha-signalling pathways. Comp. Hepatol. 3:2.
8. Bettin, C., Oehlmann, J., and Stroben, E. 1996. TBT-induced imposex in marine neogastropods is mediated by an increased androgen level. Helgolander Meeresuntersuchungen 50:299-317.
9. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
10. Brunnberg, S., Pettersson, K., Rydin, E., Matthews, J., Hanberg, A., and Pongratz, I. 2003. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc. Natl. Acad. Sci. USA 100:6517-6522.
11. Burke, M. D., Thompson, S., Weaver, R. J., Wolf, C. R., and Mayer, R. T. 1994. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem. Pharmacol. 48:923-936.
12. Burton, J. E., Dorociak, I. R., Schwedler, T. E., and Rice, C. D. 2002. Circulating lysozyme and hepatic CYP1A activities during a chronic dietary exposure to tributyltin (TBT) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126) mixtures in channel catfish, Ictalurus punctatus. J. Toxicol. Environ. Health A 65: 589-602.
13. Castro, L. F. C., Lima, D., Machado, A., Melo, C., Hiromori, Y., Nishikawa, J., Nakanishi, T., Reis-Henriques, M. A., and Santos, M. M. 2007. Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus. Aquat. Toxicol. 85:57-66.
14. Champ, M. A. 2000. A review of organotin regulatory strategies, pending actions, related costs and benefits. Sci. Total Environ. 258:21-71.
15. Choi, S. M., Yoo, S. D., and Lee, B. M. 2004. Toxicological characteristics of endocrine-disrupting chemicals: Developmental toxicity, carcinogenicity and mutagenicity. J. Toxicol. Environ. Health B 7:1-24.
16. de Mora, S. J., Fowler, S. W., Cassi, R., and Tolosa, I. 2003. Assessment of organotin contamination in marine sediments and biota from the Gulf and adjacent region. Mar. Pollut. Bull. 46:401-409.
17. DeRosa, C., Richter, P., Pohl, H., and Jones D.E. 1998 Environmental exposures that affect the endocrine system: Public health implications. J. Toxicol. Environ. Health B 1:3-26.
18. Gu, Y. Z., Hogenesch, J. B., and Bradfield, C. A. 2000. The PAS superfamily: Sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40:519-561.
19. Guillette, L. J., Jr., and Gunderson, M. P. 2001. Alterations in development of reproductive and endocrine systems of wildlife populations exposed to endocrine-disrupting contaminants. Reproduction 122:857-864.
20. Hahn, M. E. 2002. Aryl hydrocarbon receptors: Diversity and evolution. Chem. Biol. Interact. 141:131-160.
21. Hahn, M. E., Karchner, S. I., Evans, B. R., Franks, D. G., Merson, R. R., and Lapseritis, J. M. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: Insights from comparative genomics. J. Exp. Zool. A Comp. Exp. Biol. 305:693-706.
22. Hasselberg, L., Grosvik, B. E., Goksoyr, A., and Celander, M. C. 2005. Interactions between xenoestrogens and ketoconazole on hepatic CYP1A and CYP3A, in juvenile Atlantic cod (Gadus morhua). Comp. Hepatol. 4:2.
23. Horiguchi, T., Shiraishi, H., Shimizu, M., and Morita, M. 1997. Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell, Thais clavigera. Environ. Pollut. 95:85-91.
24. Iguchi, T., Watanabe, H., Ohta, Y., and Blumberg, B. 2008. Developmental effects: Oestrogen-induced vaginal changes and organotin-induced adipogenesis. Int. J. Androl. 31:263-268.
25. Kwon, J. Y., Haghpanah, V., Kogson-Hurtado, L. M., McAndrew, B. J., and Penman, D. J. 2000. Masculinization of genetic female nile tilapia (Oreochromis niloticus) by dietary administration of an aromatase inhibitor during sexual differentiation. J. Exp. Zool. 287:46-53.
26. Lyssimachou, A., Jenssen, B. M., and Arukwe, A. 2006. Brain cytochrome P450 aromatase gene isoforms and activity levels in Atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin. Toxicol. Sci. 91:82-92.
27. Merson, R. R., Franks, D. G., Karchner, S. I., and Hahn, M. E. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 142:85-94.
28. Michaud, M. H., and Pelletier, É. 2006. Sources and fate of butyltins in the St. Lawrence Estuary ecosystem. Chemosphere 64:1074-1082.
29. Morcillo, Y., Janer, G., O'Hara, S. C., Livingstone, D. R., and Porte, C. 2004. Interaction of tributyltin with hepatic cytochrome P450 and uridine diphosphate-glucuronosyl transferase systems of fish: in vitro studies. Environ. Toxicol. Chem. 23:990-996.
30. Mortensen, A. S., and Arukwe, A. 2007a. Interactions between estrogen- and Ah-receptor signalling pathways in primary culture of salmon hepatocytes exposed to nonylphenol and 3,3′,4,4′-tetrachlorobiphenyl (congener 77). Comp. Hepatol. 6:2.
31. Mortensen, A. S., and Arukwe, A. 2007b. Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 145:431-441.
32. Mortensen, A. S., and Arukwe, A. 2008. Activation of estrogen receptor signaling by the dioxin-like aryl hydrocarbon receptor agonist, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126 in salmon in vitro system. Toxicol. Appl. Pharmacol. 227:313-324.
33. Navas, J. M., and Segner, H. 2000. Antiestrogenicity of beta-naphthoflavone and PAHs in cultured rainbow trout hepatocytes: Evidence for a role of the arylhydrocarbon receptor. Aquat. Toxicol. 51:79-92.
34. Ohira, S., Enomoto, M., and Matsui, H. 2006. In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms. Toxicology.
35. Ohno, S., Nakajima, Y., and Nakajin, S. 2005. Triphenyltin and tributyltin inhibit pig testicular 17[beta]-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis. Steroids 70:645-651.
36. 2+, protein kinase C and proteases. Biochim. Biophys. Acta (BBA) Mol. Cell Res. 1448:473-485.
37. Rice, C. D., and Roszell, L. E. 1998. Tributyltin modulates 3,3′,4,4′,5-pentachlorobiphenyl (PCB-126)-induced hepatic CYP1A activity in channel catfish, Ictalurus punctatus. J. Toxicol. Environ. Health A 55:197-212.
38. Roy, D., Palangat, M., Chen, C.-W., Thomas, R.D., Colerangle, J., Atkinson, A., and Yan, Z-J. 1997 Biochemical and molecular changes at the cellular level in response to ex[posure to environmental estrogen-like chemicals. J. Toxicol. Environ. Health 50:1-29.
39. Sabo-Attwood, T., Kroll, K. J., and Denslow, N. D. 2004. Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol. Mol. Cell. Endocrinol. 218:107-118.
40. Safe, S., Astroff, B., Harris, M., Zacharewski, T., Dickerson, R., Romkes, M., and Biegel, L. 1991. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: Characterization and mechanism of action. Pharmacol. Toxicol. 69:400-409.
41. Safe, S., Bandiera, S., Sawyer, T., Zmudzka, B., Mason, G., Romkes, M., Denomme, M. A., Sparling, J., Okey, A. B., and Fujita, T. 1985. Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction-halogenated biphenyls. Environ. Health Perspect. 61:21-33.
42. Saitoh, M., Yanase, T., Morinaga, H., Tanabe, M., Mu, Y. M., Nishi, Y., Nomura, M., Okabe, T., Goto, K., Takayanagi, R., and Nawata, H. 2001. Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN. Biochem. Biophys. Res. Commun. 289:198-204.
43. Santos, M. M., Castro, L. F. C., Vieira, M. N., Micael, J., Morabito, R., Massanisso, P., and Reis-Henriques, M. A. 2005. New insights into the mechanism of imposex induction in the dogwhelk Nucella lapillus. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 141:101-109.
44. Santos, M. M., Micael, J., Carvalho, A. P., Morabito, R., Booy, P., Massanisso, P., Lamoree, M., and Reis-Henriques, M. A. 2006. Estrogens counteract the masculinizing effect of tributyltin in zebrafish. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 142:151-155.
45. Satoh, K., Nagai, F., and Aoki, N. 2001. Several environmental pollutants have binding affinities for both androgen receptor and estrogen receptor alpha. J. Health Sci. 47:495-501.
46. Steele, B. K., Meyers, C., and Ozbun, M. A. 2002. Variable expression of some "housekeeping" genes during human keratinocyte differentiation. Anal. Biochem. 307:341-347.
47. Tillmann, M., Schulte-Oehlmann, U., Duft, M., Markert, B., and Oehlmann, J. 2001. Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens. Ecotoxicology 10:373-388.
48. Wierman, M. E. 2007. Sex steroid effects at target tissues: mechanisms of action. Adv. Physiol. Edu. 31:26-33.
49. Wyde, M. E., Bartolucci, E., Ueda, A., Zhang, H., Yan, B., Negishi, M., and You, L. 2003. The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor. Mol. Pharmacol. 64:474-481.
50. Yamabe, Y., Hoshino, A., Imura, N., Suzuki, T., and Himeno, S. 2000. Enhancement of androgen-dependent transcription and cell proliferation by tributyltin and triphenyltin in human prostate cancer cells. Toxicol. Appl. Pharmacol. 169:177-184.
51. Yamauchi, M., Kim, E. Y., Iwata, H., and Tanabe, S. 2005. Molecular characterization of the aryl hydrocarbon receptors (AHR1 and AHR2) from red seabream (Pagrus major). Comp Biochem Physiol C Toxicol Pharmacol 141:177-187.