Triphenyltin and Tributyltin inhibit pig testicular 17β-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis

Steroids

Volumn 70, Issue 9, 2005, Pages 645-651

  Ohno, Shuji ^a   Nakajima, Yonako ^a   Nakajin, Shizuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

17 Hydroxysteroid dehydrogenase; Enzyme inhibition; Organotin; Pig testis; TBT and TPT; Testosterone production

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL; CYTOCHROME P450; DITHIOERYTHRITOL; DITHIOTHREITOL; FERREDOXIN; LYASE; MICROSOME ENZYME; ORGANOTIN COMPOUND; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRIBUTYLTIN; TRIPHENYLTIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE ACTION; IC 50; LEYDIG CELL; MALE; MICROSOME; NONHUMAN; SENSITIVITY ANALYSIS; SWINE; TESTIS; TESTOSTERONE SYNTHESIS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ANIMALS, NEWBORN; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DITHIOERYTHRITOL; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FERREDOXIN-NADP REDUCTASE; LEYDIG CELLS; MALE; MICROSOMES; MITOCHONDRIA; NADPH-FERRIHEMOPROTEIN REDUCTASE; ORGANOTIN COMPOUNDS; STEROID 17-ALPHA-HYDROXYLASE; SWINE; TESTIS; TESTOSTERONE; TRIALKYLTIN COMPOUNDS;

SUS SCROFA;

EID: 21344458134     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.03.005     Document Type: Article

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