From bugs to drugs - Mining the gut microbiota

Current Gastroenterology Reports

Volumn 10, Issue 6, 2008, Pages 515-516

  Shanahan, Fergus ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; BACTERIOCIN; DEFENSIN; MORPHINE; POLYPEPTIDE ANTIBIOTIC AGENT; PROBIOTIC AGENT;

ANTIINFLAMMATORY ACTIVITY; BACTERIAL COLONIZATION; COMMENSAL; DRUG EFFICACY; DRUG RESEARCH; DRUG SAFETY; DRUG TARGETING; ENTERITIS; GASTROENTEROLOGY; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOREGULATION; INTESTINE FLORA; IRRITABLE COLON; LACTOBACILLUS; MUCOSAL IMMUNITY; NONHUMAN; NOTE; OBESITY;

DRUG DESIGN; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRACT; GENOME, HUMAN; HUMANS;

EID: 60749084415     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-008-0094-8     Document Type: Note

References (18)

1. Caskey CT: The drug devElopment crisis: efficiency and safety. Annu Rev Med 2007, 58: 1-16.
2. Parsons ME, Garner A: Drug development in gastroenterology - the changing view of industry. Aliment Pharmacol Ther 1995, 9: 457-463.
3. Shanahan F, Kiely B: The gut microbiota and disease - an inner repository for drug discovery. Drug Discov Today: Ther Strategies 2007, 4: 195-200.
4. O'Hara AM, Shanahan F: The gut flora as a forgotten organ. EMBO Rep 2006, 7: 688-693.
5. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL: An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122: 107-118.
6. Mazmanian SK, Round JL, Kasper DL: A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453: 620-625.
7. Rachmilewitz D, Katakura K, Karmeli F, et al.: Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004, 126: 520-528.
8. Yan F, Cao H, Cover TL, et al.: Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 2007, 132: 562-575.
9. Fujiya M, Musch MW, Nakagawa Y, et al.: The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe 2007, 1: 299-308.
10. Rea MC, Clayton E, O'Connor PM, et al.: Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains. J Med Microbiol 2007, 56: 940-946.
11. Coakley M, Ross RP, Nordgren M, et al.: Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. J Appl Microbiol 2003, 94: 138-145.
12. Rosberg-Cody E, Ross RP, Hussey S, et al.: Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteria. Appl Environ Microbiol 2004, 70: 4635-4641.
13. Marchesi J, Shanahan F: The normal intestinal microbiota. Curr Opin Infect Dis 2007, 20: 508-513.
14. Dumas ME, Barton RH, Toye A, et al.: Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 2006, 103: 12511-12516.
15. Backhed F, Ding H, Wang T, et al.: The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004, 101: 15718-15723.
16. Rousseaux C, Thuru X, Gelot A, et al.: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med 2007, 13: 35-37.
17. Turnbaugh PJ, Ley RE, Hamady M, et al.: The human microbiome project. Nature 2007, 449: 804-810.
18. Venter JC: A Life Decoded. My Genome: My Life. London: Allen Lane/ Penguin; 2007.