Inhibition of coagulation activation and inflammation by a novel factor xa inhibitor synthesized from the earthworm Eisenia andrei

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 2, 2009, Pages 253-258

  Joo, Seong Soo ^a   Won, Tae Joon ^b   Kim, Jong Sung ^b   Yoo, Yeong Min ^a   Tak, Eun Sik ^b   Park, So Young ^c   Park, Hee Yong ^b   Hwang, Kwang Woo ^b   Park, Soon Cheol ^b   Lee, Do Ik ^b  

^a Chungbuk National University   (South Korea)

^b Chung Ang University   (South Korea)

^c Korea University College of Medicine   (South Korea)

Author keywords

Antistasin; Eisenstasin; Factor xa; Inflammation; Nitric oxide; Proteinase activated receptor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; CHROMOGENIC SUBSTRATE; EISENIA ANDREI DERIVATIVE; EISENTSASIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INTERLEUKIN 16; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NATURAL PRODUCT; PROTEINASE ACTIVATED RECEPTOR 2; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; CYTOKINE PRODUCTION; EARTHWORM; EISENIA ANDREI; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LEECH; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICOAGULANTS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE; CYTOKINES; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FACTOR XA; HUMANS; INVERTEBRATE HORMONES; NITRIC OXIDE; OLIGOCHAETA; PHOSPHORYLATION; RECEPTOR, PAR-1;

EID: 60749083890     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.253     Document Type: Article

References (30)

1. De Bruin E. C., Roem D., Bulder I., Dieker M., Voerman G., Hack C., FEMS Yeast Res., 5, 1069-1077 (2005).
2. Iwanaga S., Curr. Opin. Immunol., 5, 74-82 (1993).
3. Chu V, Brown K., Colussi D., Gao J., Bostwick J., Kasiewski C., Bent-ley R., Morgan S., Guertin K., Pauls H. W., Gong Y., Zulli A., Perrone M. H., Dunwiddie C. T., Leadley R. J., Thromb. Res., 15, 309-324 (2001).
4. Herbert J. M., Bono F., Herault J. P., Avril C., Dol F., Mares A. M., Schaeffer P., J. Clin. Invest., 101, 993-1000 (1998).
5. Papapetropoulos A., Piccardi P., Cirino G., Bucci M., Sorrentino R., Cicala C., Johnson K., Zachariou V, Sessa W. C., Altieri D. C., Proc. Natl. Acad. Sci. U.S.A., 95, 4738-4742 (1998).
6. Senden N. H., Jeunhomme T. M., Heemskerk J. W., Wagenvoord R., van't Veer C., Hemker H. C., Buurman W.A., J. Immunol., 161, 4318-4324 (1998).
7. Camerer E., Rottingen J. A., Gjernes E., Larsen K., Skartlien A. H., Iversen J. G., Prydz H., J. Biol. Chem., 274, 32225-32233 (1999).
8. Tuszynski G. P., Gasic T. B., Gasic G. J., J. Biol. Chem., 262, 9718-9723 (1987).
9. Blankenship D. T., Brankamp R. G., Manley G. D., Biochem. Biophys. Res. Commun., 166, 1384-1389 (1990).
10. Salzet M., FEBSLett., 492, 187-192 (2001).
11. Nicholson A. C., Nachman R. L., Altieri D. C., Summers B. D., Ruf W., Edgington T. S., Hajjar D. P., J Biol. Chem., 271, 28407-28413 (1996).
12. Bono F., Schaeffer P., Hérault J. P., Michaux C., Nestor A. L., Guillemot J. C., Herbert J. M., Arterioscler. Thromb. Vasc. Biol., 20, e107-e112 (2000).
13. Coughlin S. R., Nature (London), 407, 258-264 (2000).
14. Saifeddine M., Al-Ani B., Cheng C. H., Wang L., Hollenberg M. D., Br. J. Pharmacol., 118, 521-530 (1996).
15. Vlasuk G. P., Thromb. Haemost., 70, 212-216 (1993).
16. Hara T., Yokoyama A., Ishihara H., Yokoyama Y., Nagahara T., Iwamoto M., Thromb. Haemost., 71, 314-319 (1994).
17. Hauptmann J., Sturzebecher J., Thromb. Res., 94, 203-241 (1999).
18. Pager N. A., Abendschein D. R., McKenzie C. R., Eisenberg P. R., Circulation, 92, 962-967 (1993).
19. Ohta N., Brush M., Jacobs J. W., Thromb. Haemost., 72, 825-830 (1994).
20. Chu V., Brown K., Colussi D., Choi Y. M., Green D., Pauls H. W., Spara A. P., Perone M. H., Leadly R. J., Dunwiddie C. T., Thromb. Res., 99, 71-82 (2000).
21. Nagai K., Perutz M. F., Proc. Natl. Acad. Sci. U.S.A., 82, 7252-7275 (1985).
22. Levi M., van der Poll T., Circulation, 109, 2698-2704 (2004).
23. Lee M. S., Cho S. J., Tak E. S., Lee J. A., Cho H. J., Park B. J., Shin C., Kim D. K., Park S. C., Biochem. Biophys. Res. Commun., 328, 1196-1204 (2005).
24. Chopin V., Salzet M., Baert J., Vandenbulcke F., Sautiere P. E., Kerck- aert J. P., Malecha J., J. Biol. Chem., 275, 32701-32707 (2000).
25. Riewald M., Ruf W., Trends Cardiovasc. Med., 12, 149-154 (2002).
26. Chambers R. C., Br. J. Pharmacol., 153, S367-S378 (2008).
27. Steinhoff M., Vergnolle N., Young S. H., Tognetto M., Amadesi S., Ennes H. S., Trevisani M., Hollenberg M. D., Wallace J. L., Caughey G. H., Mitchell S. E., Williams L. M., Geppetti P., Mayer E. A., Bun-nett N. W., Nat. Med., 6, 151-158 (2000).
28. Bono F., Lamarche I., Herbert J. M., Biochem. Biophys. Res. Commun., 241, 762-764 (1997).
29. Vergnolle N., J. Immunol., 163, 5064-5069 (1999).
30. Vergnolle N., Hollenberg M. D., Sharkey K. A., Wallace J. L., Br. J. Pharmacol., 127, 1083-1090 (1999).