Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo

Journal of Endodontics

Volumn 35, Issue 3, 2009, Pages 367-372

  Okamoto, Yosuke ^a   Sonoyama, Wataru ^a   Ono, Mitsuaki ^a   Akiyama, Kentaro ^a,b   Fujisawa, Takuo ^a   Oshima, Masamitsu ^a   Tsuchimoto, Yohei ^a   Matsuka, Yoshizo ^a   Yasuda, Tatsuji ^a   Shi, Songtao ^b   Kuboki, Takuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cell differentiation; cell proliferation; dental pulp stem cells; dentin regeneration; pulp capping material; reparative dentin formation; simvastatin

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; DSPP PROTEIN, HUMAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OSTEOCALCIN; SCLEROPROTEIN; SIMVASTATIN;

ADULT; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; STEM CELL; TOOTH PULP; TOOTH PULP DISEASE; UPREGULATION;

ADULT; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DENTAL PULP; DENTIN, SECONDARY; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX PROTEINS; G1 PHASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; OSTEOCALCIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIMVASTATIN; STEM CELLS; UP-REGULATION; YOUNG ADULT;

EID: 60649115269     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2008.11.024     Document Type: Article

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