N-Acylated and N,N′-diacylated imidazolidine-2-thione derivatives and N,N′-diacylated tetrahydropyrimidine-2(1H)-thione analogues: Synthesis and antiproliferative activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1106-1118

  Cesarini, Sara ^a   Spallarossa, Andrea ^a   Ranise, Angelo ^a   Schenone, Silvia ^a   Rosano, Camillo ^b   La Colla, Paolo ^c   Sanna, Giuseppina ^c   Busonera, Bernardetta ^c   Loddo, Roberta ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Acylthioureas; Antiproliferative activity; Parallel synthesis

Indexed keywords

1,3 BIS(2 CHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(2 CHLOROBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(2 METHYLBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(2,4 DICHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(2,4 DICHLOROBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(3 CHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(3 NITROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(3,4 DICHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(3,4 DICHLOROBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(3,4,5 TRIMETHOXYBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(3,4,5 TRIMETHOXYBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(3,5 DICHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(3,5 DICHLOROBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(4 CHLOROBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(4 CHLOROBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(4 METHOXYBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(4 METHYLBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(4 METHYLBENZOYL)TETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 BIS(4 TERT BUTYLBENZOYL)IMIDAZOLIDINE 2 THIONE; 1,3 BIS(THIEN 2 YLCARBONYL)IMIDAZOLIDINE 2 THIONE; 1,3 DI 1 NAPHTHOYLIMIDAZOLIDINE 2 THIONE; 1,3 DI 2 FUROYLIMIDAZOLIDINE 2 THIONE; 1,3 DI 2 FUROYLTETRAHYDROPYRIMIDINE 2(1H) THIONE; 1,3 DIACETYLIMIDAZOLIDINE 2 THIONE; 1,3 DIBENZOYLIMIDAZOLIDINE 2 THIONE; 1,3 DIBENZOYLTETRAHYDROPYRIMIDINE 2(1H) THIONE; ACYLTHIOUREA DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEACYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MELANOMA CELL;

ACYLATION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLIDINES; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; SPECTROPHOTOMETRY, INFRARED;

EID: 60549111986     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.010     Document Type: Article

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