Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus

Diseases of the Esophagus

Volumn 22, Issue 2, 2009, Pages 143-150

  Kim, Young Tae ^a,b   Park, J Y ^b   Jeon, Y K ^a   Park, S J ^b   Song, J Y ^b   Kang, C H ^a   Sung, S W ^a   Kim, J H ^a  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

APC; Esophageal neoplasms; Genes; Lymph nodes; Methylation; Neoplasm metastasis

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FRAGILE HISTIDINE TRIAD PROTEIN; PROTEIN MLH1; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR BETA P2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER TISSUE; CLINICAL FEATURE; COLON POLYPOSIS; CPG ISLAND; DEATH; DNA METHYLATION; ESOPHAGUS CARCINOMA; ESOPHAGUS RESECTION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; RISK FACTOR; SQUAMOUS CELL CARCINOMA;

ADENOMATOUS POLYPOSIS COLI; AGED; CARCINOMA, SQUAMOUS CELL; CPG ISLANDS; DNA METHYLATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENES, APC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGIONS, GENETIC; RISK FACTORS;

EID: 60549100565     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2008.00862.x     Document Type: Article

References (29)

1. Zhang G, Zhou X, Xue L et al. Accumulation of cytoplasmic beta-catenin correlates with reduced expression of e-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: immunohistochemical study. Pathol Int 2005; 55: 310-7.
2. Brock M V, Gou M, Akiyama Y et al. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res 2003; 9: 2912-9.
3. Eads C A, Lord R V, Wickramasinghe K et al. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 2001; 61: 3410-8.
4. Kawakami K, Brabender J, Lord R V et al. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst 2000; 92: 1805-11.
5. Mizuiri H, Yoshida K, Toge T et al. DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. Cancer Sci 2005; 96: 571-7.
6. Kuroki T, Trapasso F, Yendamuri S et al. Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res 2003; 63: 3724-8.
7. Abbaszadegan M R, Raziee H R, Ghafarzadegan K, Shakeri M T, Afsharnezhad S, Ghavamnasiry M R. Aberrant p16 methylation, a possible epigenetic risk factor in familial esophageal squamous cell carcinoma. Int J Gastrointest Cancer 2005; 36: 47-54.
8. Hibi K, Taguchi M, Nakayama H et al. Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma. Clin Cancer Res 2001; 7: 3135-8.
9. Nie Y, Liao J, Zhao X et al. Detection of multiple gene hypermethylation in the development of esophageal squamous cell carcinoma. Carcinogenesis 2002; 23: 1713-20.
10. Hayashi M, Tamura G, Jin Z et al. Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation. Pathol Int 2003; 53: 270-6.
11. Tzao C, Hsu H S, Sun G H etal. Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg 2005; 130: 1371.
12. Kubo N, Yashiro M, Ohira M, Hori T, Fujiwara I, Hirakawa K. Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma. Int J Cancer 2005; 114: 166-73.
13. Tanaka H, Shimada Y, Harada H et al. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res 1998; 58: 3429-34.
14. Lee E J, Lee B B, Kim J W et al. Aberrant methylation of fragile histidine triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma. Eur J Cancer 2006; 42: 972-80.
15. Noguchi T, Takeno S, Kimura Y etal. FHIT expression and hypermethylation in esophageal squamous cell carcinoma. Int J Mol Med 2003; 11: 441-7.
16. Tzao C, Sun G H, Tung H J et al. Reduced acetylated histone H4 is associated with promoter methylation of the fragile histidine triad gene in resected esophageal squamous cell carcinoma. Ann Thorac Surg 2006; 82: 396-401; discussion.
17. Yamaguchi S, Kato H, Miyazaki T et al. RASSF1A gene promoter methylation in esophageal cancer specimens. Dis Esophagus 2005; 18: 253-6.
18. Wong M L, Tao Q, Fu L et al. Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma. Int J Oncol 2006; 28: 767-73.
19. Liotta L A, Stetler-Stevenson W G. Tumor invasion and metastasis: An imbalance of positive and negative regulation. Cancer Res 1991; 51: 5054s-9s.
20. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451-5.
21. Polakis P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1997; 1332: F127-47.
22. Wijnhoven B P, Nollet F, De Both N J, Tilanus H W, Dinjens W N. Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus. Int J Cancer 2000; 86: 533-7.
23. Behrens J, von Kries J P, Kuhl M et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996; 382: 638-42.
24. Clevers H, van de Wetering M. TCF/LEF factor earn their wings. Trends Genet 1997; 13: 485-9.
25. Aoki M, Hecht A, Kruse U, Kemler R, Vogt P K. Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1. Proc Natl Acad Sci U S A 1999; 96: 139-44.
26. Arnold C N, Goel A, Niedzwiecki D et al. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. Cancer Biol Ther 2004; 3: 960-4.
27. Kudo Y, Kitajima S, Ogawa I et al. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin. Clin Cancer Res 2004; 10: 5455-63.
28. Kim Y T, Lee S H, Sung S W, Kim J H. Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection? Ann Thorac Surg 2005; 79: 1180-8; discussion-8.
29. Kim Y T, Park S J, Lee S H et al. Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung. J Thorac Cardiovasc Surg 2005; 130: 1378-84.