Using differential gene expression to study Entamoeba histolytica pathogenesis

Trends in Parasitology

Volumn 25, Issue 3, 2009, Pages 124-131

  Gilchrist, Carol A ^a   Petri Jr , William A ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

AMEBIASIS; BIOLOGY; COMPARATIVE STUDY; ENTAMOEBA HISTOLYTICA; EPIGENETICS; GENE EXPRESSION; GENE OVEREXPRESSION; GENOMICS; HUMAN; LIFE CYCLE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE STRESS; PARASITE ISOLATION; PARASITE VIRULENCE; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTOZOON; REVIEW; TROPHOZOITE; UPREGULATION;

ANIMALS; DISEASE MODELS, ANIMAL; ENTAMOEBA HISTOLYTICA; ENTAMOEBIASIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTOZOAN PROTEINS; VIRULENCE;

ENTAMOEBA HISTOLYTICA; PROTOZOA;

EID: 60449117752     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2008.12.007     Document Type: Review

References (51)

1. Duggal P., et al. Influence of human leukocyte antigen class II alleles on susceptibility to Entamoeba histolytica infection in Bangladeshi children. J. Infect. Dis. 189 (2004) 520-526
2. Ali I.K., et al. Evidence for a link between parasite genotype and outcome of infection with Entamoeba histolytica. J. Clin. Microbiol. 45 (2007) 285-289
3. Mondal D., et al. Entamoeba histolytica-associated diarrheal illness is negatively associated with the growth of preschool children: evidence from a prospective study. Trans. R. Soc. Trop. Med. Hyg. 100 (2006) 1032-1038
4. Haque R., et al. Amebiasis. N. Engl. J. Med 348 (2003) 1565-1573
5. + T cells. J. Immunol. 169 (2002) 4496-4503
6. Davis P.H., et al. Transcriptomic comparison of two Entamoeba histolytica strains with defined virulence phenotypes identifies new virulence factor candidates and key differences in the expression patterns of cysteine proteases, lectin light chains, and calmodulin. Mol. Biochem. Parasitol. 151 (2007) 118-128
7. MacFarlane R.C., and Singh U. Identification of differentially expressed genes in virulent and nonvirulent Entamoeba species: potential implications for amebic pathogenesis. Infect. Immun. 74 (2006) 340-351
8. Gilchrist C.A., et al. Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome. Mol. Biochem. Parasitol. 147 (2006) 163-176
9. Ayeh-Kumi P.F., et al. Entamoeba histolytica: genetic diversity of clinical isolates from Bangladesh as demonstrated by polymorphisms in the serine-rich gene. Exp. Parasitol. 99 (2001) 80-88
10. Ali I.K., et al. Tissue invasion by Entamoeba histolytica: evidence of genetic selection and/or DNA reorganization events in organ tropism. PLoS Negl. Trop. Dis. 2 (2008) e219
11. Davis P.H., et al. Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence. Mol. Microbiol. 61 (2006) 1523-1532
12. Ehrenkaufer G.M., et al. Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechanisms of stage conversion in a protozoan parasite. Cell. Microbiol. 9 (2007) 1426-1444
13. Bruchhaus I., et al. Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica. Biochem. J. 326 (1997) 785-789
14. Hughes M.A., et al. Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein. Mol. Biochem. Parasitol. 127 (2003) 113-120
15. Akbar M.A., et al. Genes induced by a high-oxygen environment in Entamoeba histolytica. Mol. Biochem. Parasitol. 133 (2004) 187-196
16. Vicente J.B., et al. Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stress: implications for amebic pathogenesis. Cell Microbiol. 11 (2009) 51-69
17. Weber C., et al. Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica. Eukaryot. Cell 5 (2006) 871-875
18. Hackney J.A., et al. Identification of putative transcriptional regulatory networks in Entamoeba histolytica using Bayesian inference. Nucleic Acids Res. 35 (2007) 2141-2152
19. Macfarlane R.C., and Singh U. Identification of an Entamoeba histolytica serine, threonine, isoleucine, rich protein with roles in adhesion and cytotoxicity. Eukaryot. Cell 6 (2007) 2139-2146
20. Loftus B., et al. The genome of the protist parasite Entamoeba histolytica. Nature 433 (2005) 865-868
21. Yang Y.H., et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30 (2002) e15
22. Tusher V.G., et al. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 5116-5121
23. Severgnini M., et al. Strategies for comparing gene expression profiles from different microarray platforms: application to a case-control experiment. Anal. Biochem. 353 (2006) 43-56
24. Bruchhaus I., et al. Differential gene expression in Entamoeba histolytica isolated from amoebic liver abscess. Mol. Microbiol. 44 (2002) 1063-1072
25. Santi-Rocca J., et al. The lysine- and glutamic acid-rich protein KERP1 plays a role in Entamoeba histolytica liver abscess pathogenesis. Cell. Microbiol. 10 (2008) 202-217
26. Sahoo N., et al. Calcium binding protein 1 of the protozoan parasite Entamoeba histolytica interacts with actin and is involved in cytoskeleton dynamics. J. Cell Sci. 117 (2004) 3625-3634
27. Chakrabarty P., et al. Identification and characterization of EhCaBP2. A second member of the calcium-binding protein family of the protozoan parasite Entamoeba histolytica. J. Biol. Chem. 279 (2004) 12898-12908
28. Sen A., et al. The 29-kilodalton thiol-dependent peroxidase of Entamoeba histolytica is a factor involved in pathogenesis and survival of the parasite during oxidative stress. Eukaryot. Cell 6 (2007) 664-673
29. Seigneur M., et al. A lysine- and glutamic acid-rich protein, KERP1, from Entamoeba histolytica binds to human enterocytes. Cell. Microbiol. 7 (2005) 569-579
30. Abhyankar M.M., et al. Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection. Eukaryot. Cell 7 (2008) 1565-1572
31. Gilchrist C.A., et al. Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs. J. Biol. Chem. 276 (2001) 11838-11843
32. +-binding transcription factor URE3-BP. J. Biol. Chem. 278 (2003) 4646-4653
33. Gilchrist C.A., et al. Targets of the Entamoeba histolytica transcription factor URE3-BP. PLoS Negl. Trop. Dis. 2 (2008) e282
34. Blazquez S., et al. Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin activity. Cell Microbiol. 8 (2008) 1676-1686
35. Stanley Jr. S.L. Amoebiasis. Lancet 361 (2003) 1025-1034
36. Goff L.A., et al. Evaluation of sense-strand mRNA amplification by comparative quantitative PCR. BMC Genomics 5 (2004) 76
37. Hunter S.M., et al. Optimization of minuscule samples for use with cDNA microarrays. J. Biochem. Biophys. Methods 70 (2008) 1048-1058
38. Puskas L.G., et al. RNA amplification results in reproducible microarray data with slight ratio bias. Biotechniques 32 (2002) 1330-1334 1336, 1338, 1340
39. Eisen M.B., et al. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14863-14868
40. Bruchhaus I., et al. The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation. Eukaryot. Cell 2 (2003) 501-509
41. Ebert F., et al. An Entamoeba cysteine peptidase specifically expressed during encystation. Parasitol. Int. 57 (2008) 521-524
42. Singh U., and Ehrenkaufer G.M. Recent insights into Entamoeba development: identification of transcriptional networks associated with stage conversion. Int. J. Parasitol. 39 (2008) 41-47
43. Eichinger D. A role for a galactose lectin and its ligands during encystment of Entamoeba. J. Eukaryot. Microbiol. 48 (2001) 17-21
44. Ehrenkaufer G.M., et al. Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica. BMC Genomics 8 (2007) 216
45. Ramakrishnan G., et al. Histone acetyltransferases and deacetylase in Entamoeba histolytica. Mol. Biochem. Parasitol. 138 (2004) 205-216
46. Isakov E., et al. Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica. Mol. Biochem. Parasitol. 158 (2008) 82-94
47. Lavi T., et al. EhMLBP is an essential constituent of the Entamoeba histolytica epigenetic machinery and a potential drug target. Mol. Microbiol. 69 (2008) 55-66
48. Ali I.K., et al. Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expression. BMC Genomics 8 (2007) 7
49. Beck D.L., et al. Identification and gene expression analysis of a large family of transmembrane kinases related to the Gal/GalNAc lectin in Entamoeba histolytica. Eukaryot. Cell 4 (2005) 722-732
50. Mehra A., et al. Expression and function of a family of transmembrane kinases from the protozoan parasite Entamoeba histolytica. Infect. Immun. 74 (2006) 5341-5351
51. Edgar R., et al. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30 (2002) 207-210