Chemotaxis of Entamoeba histolytica towards the pro-inflammatory cytokine TNF is based on PI3K signalling, cytoskeleton reorganization and the Galactose/N-acetylgalactosamine lectin activity

Cellular Microbiology

Volumn 10, Issue 8, 2008, Pages 1676-1686

  Blazquez, Samantha ^a,b   Guigon, Ghislaine ^a   Weber, Christian ^a,b   Syan, Sylvie ^a,b   Sismeiro, Odile ^a   Coppée, Jean Yves ^a   Labruyère, Elisabeth ^a,b   Guillén, Nancy ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; CYTOSKELETON PROTEIN; GALACTOSE N ACETYLGALACTOSAMINE LECTIN; LECTIN; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR;

ARTICLE; CELL MOTILITY; CHEMOTAXIS; CONTROLLED STUDY; CYTOSKELETON; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION REGULATION; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE MIGRATION; PARASITE VIRULENCE; POLARIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACETYLGALACTOSAMINE; ANDROSTADIENES; ANIMALS; CHEMOTAXIS; CYTOSKELETON; ENTAMOEBA HISTOLYTICA; GALACTOSE; GENE EXPRESSION; HUMANS; LECTINS; PROTOZOAN PROTEINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS;

ENTAMOEBA HISTOLYTICA; PROTOZOA;

EID: 47649101100     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01158.x     Document Type: Article

References (39)

1. Abd-Alla, M.D., Jackson, T.F., Soong, G.C., Mazanec, M., and Ravdin, J.I. (2004) Identification of the Entamoeba histolytica galactose-inhibitable lectin epitopes recognized by human immunoglobulin A antibodies following cure of amebic liver abscess. Infect Immun 72: 3974-3980.
2. Arhets, P. (1997) Bases moléculaires du capping des récepteurs de surface chez Entamoeba histolytica. PhD thesis. Paris, France: Paris-Sud University.
3. Arhets, P., Gounon, P., Sansonetti, P., and Guillén, N. (1995) Myosin II is involved in capping and uroid formation in the human pathogen Entamoeba histolytica. Infect Immun 63: 4358-4367.
4. Arhets, P., Olivo, J.-C., Gounon, P., Sansonetti, P., and Guillén, N. (1998) Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica. Mol Biol Cell 9: 1537-1547.
5. Blazquez, S., Zimmer, C., Guigon, G., Olivo-Marin, J.-C., Guillén, N., and Labruyère, E. (2006) Human tumor necrosis factor is a chemoattractant for the parasite Entamoeba histolytica. Infect Immun 74: 1407-1411.
6. Chung, C.Y., Potikyan, G., and Firtel, R.A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 7: 937-947.
7. Coudrier, E., Amblard, F., Zimmer, C., Roux, P., Olivo-Marin, J.-C., Rigothier, M.-C., and Guillén, N. (2005) Myosin II and the Gal/ GalNAc lectin play a crucial role in tissue invasion by Entamoeba histolytica. Cell Microbiol 7: 19-27.
8. Delmar, P., Robin, S., and Daudin, J.J. (2005) VarMixt: Efficient variance modelling for the differential analysis of replicated gene expression data. Bioinformatics 21: 502-508.
9. Devreotes, P., and Janetopoulos, C. (2003) Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem 278: 20445-20448.
10. Diamond, L.S., Harlow, D.R., and Cunnick, C.C. (1978) A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans R Soc Trop Med Hyg 72: 431-432.
11. Eisenbach, M. (2004) Chemotaxis. London: Imperial College Press.
12. Franco, E., Vázquez-Prado, J., and Meza, I. (1997) Fibronectin-derived fragments as inducers of adhesion and chemotaxis of Entamoeba histolytica trophozoites. J Infect Dis 176: 1597-1602.
13. Ghosh, S.K., and Samuelson, J. (1997) Involvement of p21racA, phosphoinositide 3-kinase, and vacuolar ATPase in phagocytosis of bacteria and erythrocytes by Entamoeba histolytica: Suggestive evidence for coincidental evolution of amebic invasiveness. Infect Immun 65: 4243-4249.
14. Guillén, N. (1996) Role of signalling and cytoskeletal rearrangements in the pathogenesis of Entamoeba histolytica. Trends Microbiol 4: 191-197.
15. Hamann, L., Nickel, R., and Tannich, E. (1995) Transfection and continuous expression of heterologous genes in the protozoan parasite Entamoeba histolytica. Proc Natl Acad Sci USA 92: 8975-8979.
16. Labruyère, E., Zimmer, C., Galy, V., Olivo-Marin, J.-C., and Guillén, N. (2003) EhPAK, a member of the p21-activated kinase family, is involved in the control of Entamoeba histolytica migration and phagocytosis. J Cell Sci 116: 61-71.
17. Manahan, C.L., Iglesias, P.A., Long, Y., and Devreotes, P.N. (2004) Chemoattractant signaling in Dictyostelium discoideum. Annu Rev Cell Dev Biol 20: 223-253.
18. Marion, S., Tavares, P., Arhets, P., and Guillén, N. (2004) Signal transduction through the Gal/GalNAc lectin of Entamoeba histolytica involves a spectrin-like protein. Mol Biochem Parasitol 135: 31-38.
19. Mseka, T., Bamburg, J.R., and Cramer, L.P. (2007) ADF/cofilin family proteins control formation of oriented actin-filament bundles in the cell body to trigger fibroblast polarization. J Cell Sci 120: 4332-4344.
20. Noegel, A.A., Blau-Wasser, R., Sultana, H., Müller, R., Israel, L., Schleicher, M., et al. (2004) The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell 15: 934-945.
21. Petri, W.A., Jr, Haque, R., and Mann, B.J. (2002) The bittersweet interface of parasite and host: Lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica. Annu Rev Microbiol 56: 39-64.
22. Rahim, Z., Raymond-Denise, A., Sansonetti, P., and Guillen, N. (1993) Localization of myosin heavy chain A in the human pathogen Entamoeba histolytica. Infect Immun 61: 1048-1054.
23. Rivière, C., Marion, S., Guillén, N., Bacri, J.C., Gazeau, F., and Wilhelm, C. (2007) Signaling through the phosphatidylinositol 3-kinase regulates mechanotaxis induced by local low magnetic forces in Entamoeba histolytica. J Biomech 40: 64-77.
24. Santi-Rocca, J., Weber, C., Guigon, G., Sismeiro, O., Coppee, J.Y., and Guillen, N. (2008) The lysine- and glutamic acid-rich protein KERP1 plays a role in Entamoeba histolytica liver abscess pathogenesis. Cell Microbiol 10: 202-217.
25. Sasaki, A.T., and Firtel, R.A. (2006) Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol 85: 873-895.
26. Séguin, R., Mann, B.J., Keller, K., and Chadee, K. (1995) Identification of the galactose-adherence lectin epitopes of Entamoeba histolytica that stimulate tumor necrosis factor-alpha production by macrophages. Proc Natl Acad Sci USA 92: 12175-12179.
27. Séguin, R., Mann, B.J., Keller, K., and Chadee, K. (1997) The tumor necrosis factor alpha-stimulating region of galactose-inhibitable lectin of Entamoeba histolytica activates gamma interferon-primed macrophages for amebicidal activity mediated by nitric oxide. Infect Immun 65: 2522-2527.
28. Shibasaki, F., Fukami, K., Fukui, Y., and Takenawa, T. (1994) Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunit. Biochem J 302: 551-557.
29. Stanley, S.L., Jr (2003) Amoebiasis. Lancet 361: 1025-1034.
30. Tavares, P., Rigothier, M.-C., Khun, H., Roux, P., Huerre, M., and Guillén, N. (2005) Roles of cell adhesion and cytoskeleton activity in Entamoeba histolytica pathogenesis: A delicate balance. Infect Immun 73: 1771-1778.
31. Urban, T., Jarstrand, C., and Aust-Kettis, A. (1983) Migration of Entamoeba histolytica under agarose. Am J Trop Med Hyg 32: 733-737.
32. Vartiainen, M.K., and Machesky, L.M. (2004) The WASP-Arp2/3 pathway: genetic insights. Curr Opin Cell Biol 16: 174-181.
33. Virel, A., Addario, B., and Backman, L. (2007) Characterization of Entamoeba histolytica alpha-actinin2. Mol Biochem Parasitol 154: 82-89.
34. Ward, S.G. (2004) Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 25: 67-74.
35. Weber, C., Guigon, G., Bouchier, C., Frangeul, L., Moreira, S., Sismeiro, O., et al. (2006) Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica. Eukaryot Cell 5: 871-875.
36. WHO (1997) WHO/PAHO/UNESCO report of a consultation of experts on amoebiasis. WHO Wkly Epidemiol Rec 72: 97-100.
37. Zhang, Z., Mahajan, S., Zhang, X., and Stanley, S.L. Jr (2003) Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease. Infect Immun 71: 5355-5359.
38. Zigmond, S.H., Evangelista, M., Boone, C., Yang, C., Dar, A.C., Sicheri, F., et al. (2003) Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biology 13: 1820-1823.
39. Zimmer, C., Labruyère, E., Meas-Yedid, V., Guillén, N., and Olivo-Marin, J.-C. (2002) Segmentation and tracking of migrating cells in videomicroscopy with parametric active contours: A tool for cell-based drug testing. IEEE Trans Med Imaging 21: 1212-1221.