Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 5, 2009, Pages 1431-1433

  Biju, Purakkattle ^a   Taveras, Arthur G ^a   Dwyer, Michael P ^a   Yu, Younong ^a   Chao, Jianhua ^a   Hipkin, R William ^a   Fan, Xuedong ^a   Rindgen, Diane ^a   Fine, Jay ^a   Lundell, Daniel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CXCR2 CXCR1 dual antagonist; Cyclobutenediones; Fluoroalkyl

Indexed keywords

3,4 DIAMINOCYCLOBUTENEDIONE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR1 ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; FLUORINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CYCLOBUTANES; PROTEIN BINDING; RATS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B;

EID: 60449110305     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.033     Document Type: Article

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