3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 228-231

  Biju, Purakkattle ^a   Taveras, Arthur ^a   Yu, Younong ^a   Zheng, Junying ^a   Chao, Jianhua ^a   Rindgen, Diane ^a   Jakway, James ^a   Hipkin, R William ^a   Fossetta, James ^a   Fan, Xuedong ^a   Fine, Jay ^a   Qiu, Hongchen ^a   Merritt, J Robert ^b   Baldwin, John J ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b PHARMACOPEIA INC   (United States)

Author keywords

Antagonist; CXCR2 and CXCR1 receptor; Thiadiazole 1 oxide

Indexed keywords

3,4 DIAMINO 2,5 THIADIAZOLE 1 OXIDE; CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR1 ANTAGONIST; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; GRO ALPHA PROTEIN; INTERLEUKIN 8; MYELOPEROXIDASE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; NEUTROPHIL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMOKINE CXCL1; CHEMOTACTIC FACTORS; HUMANS; INTERLEUKIN-8; KINETICS; NEUTROPHILS; OXIDES; PEROXIDASE; RATS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 37549040581     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.094     Document Type: Article

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