An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia mater and cremaster muscle

Brain Research Protocols

Volumn 13, Issue 1, 2004, Pages 1-10

  Gaber, M Waleed ^a   Yuan, Hong ^a,b   Killmar, John T ^a   Naimark, Michael D ^b   Kiani, Mohammad F ^b   Merchant, Thomas E ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Blood brain barrier; Cellular and molecular biology; Cranial window; Intravital microscopy; Leukocyte endothelial cell interactions; Membrane transport; Permeability; Tight junction

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN MICROCIRCULATION; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CREMASTER MUSCLE; ENDOTHELIUM CELL; IONIZING RADIATION; IRRADIATION; LEUKOCYTE; MALE; MEMBRANE TRANSPORT; MICROSCOPY; MICROVASCULATURE; NONHUMAN; PARENCHYMA; PIA MATER; PRIORITY JOURNAL; RAT; TECHNIQUE; THREE DIMENSIONAL IMAGING;

ANIMALS; ANTIBODIES; BLOOD-BRAIN BARRIER; CELL COMMUNICATION; CELL MEMBRANE PERMEABILITY; CRANIOTOMY; DEXTRANS; ENDOTHELIUM, VASCULAR; FLUORESCEIN-5-ISOTHIOCYANATE; IMAGE PROCESSING, COMPUTER-ASSISTED; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; MALE; MICROCIRCULATION; MICROSCOPY; MUSCLE, SKELETAL; PIA MATER; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINES; SPERMATIC CORD; TIGHT JUNCTIONS;

EID: 1942520364     PISSN: 1385299X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresprot.2003.11.005     Document Type: Article

References (26)

1. Acker J.C., Marks L.B., Spencer D.P., Yang W., Avery M.A., Dodge R.K., Rosner G.L., Dewhirst M.W. Serial in vivo observations of cerebral vasculature after treatment with a large single fraction of radiation. Radiat. Res. 149:1998;350-359.
2. Allt G., Lawrenson J.G. Is the pial microvessel a good model for blood-brain barrier studies? Brain Res. Rev. 24:1997;67-76.
3. Baatz H., Steinbauer M., Harris A.G., Krombach F. Kinetics of white blood cell staining by intravascular administration of rhodamine 6G. Int. J. Microcirc. Clin. Exp. 15:1995;85-91.
4. Bekker A.Y., Ritter A.B., Duran W.N. Analysis of microvascular permeability to macromolecules by video-image digital processing. Microvasc. Res. 38:1989;200-216.
5. Butt A.M., Jones H.C., Abbott N.J. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol. 429:1990;47-62.
6. Davson H., Segal M.B. Physiology of the CSF and Blood-Brain Barriers. 1996;CRC Press, Boca Raton. 192 pp.
7. Del Maschio A., Zanetti A., Corada M., Rival Y., Ruco L., Lampugnani M.G., Dejana E. Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J. Cell Biol. 135:1996;497-510.
8. El-Sayed M., Kiani M.F., Naimark M.D., Hikal A.H., Ghandehari H. Extravasation of poly(amidoamine) (PAMAM) dendrimers across microvascular network endothelium. Pharm. Res. 18:2001;23-28.
9. Etienne S., Adamson P., Greenwood J., Strosberg A.D., Cazaubon S., Couraud P.O. ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J. Immunol. 161:1998;5755-5761.
10. Gaber M.W., Sabek O.M., Fukatsu K., Wilcox H.G., Kiani M.F., Merchant T.E. The differences in ICAM-1 and TNF-α expression between high single fractions and fractionated irradiation in mouse brain. Int. J. Radiat. Biol. 79:2003;359-366.
11. Harlan J.M., Winn R.K., Vedder N.B., Doerschuk C.M., Rice C.L. In vivo models of leukocyte adherence to endothelium. Harlan J.M., Liu D.Y. Adhesion: Its Role in Inflammatory Disease. 1992;117-150 Freeman, New York.
12. House S.D., Lipowsky H.H. Microvascular hematocrit and red cell flux in rat cremaster muscle. Am. J. Physiol. 252:1987;H211-H222.
13. Howes A.E. Dose-rate and fractionation. Mauch P.M., Loeffler J.S. Radiation Oncology: Technology and Biology. 1994;509-513 Saunders, Philadelphia.
14. Mayhan W.G. Cellular mechanisms by which tumor necrosis factor-α produces disruption of the blood-brain barrier. Brain Res. 927:2002;144-152.
15. Michel C.C., Curry F.E. Microvascular permeability. Physiol. Rev. 79:1999;703-761.
16. Muizelaar J.P., Bouma G.J., Levasseur J.E., Kontos H.A. Effect of hematocrit variations on cerebral blood flow and basilar artery diameter in vivo. Am. J. Physiol. 262:1992;H949-H954.
17. Panes J., Anderson D.C., Miyasaka M., Granger D.N. Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats. Gastroenterology. 108:1995;1761-1769.
18. Prabhakarpandian B., Goetz D.J., Swerlick R.A., Chen X., Kiani M.F. Expression and functional significance of adhesion molecules on cultured endothelial cells in response to ionizing radiation. Microcirculation. 8:2001;355-364.
19. Renkin E.M. Capillary transport of macromolecules: pores and other endothelial pathways. J. Appl. Physiol. 58:1985;315-325.
20. Revest P.A., Jones H.C., Abbott N.J. Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier. Brain Res. 652:1994;76-82.
21. van de S.A., van der Saag P.T. Intercellular adhesion molecule-1. J. Mol. Med. 74:1996;13-33.
22. Wu N.Z., Klitzman B., Rosner G., Needham D., Dewhirst M.W. Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. Microvasc. Res. 46:1993;231-253.
23. Yuan F., Leunig M., Berk D.A., Jain R.K. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc. Res. 45:1993;269-289.
24. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchilin V.P., Jain R.K. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 55:1995;3752-3756.
25. Yuan H., Gaber M.W., McColgan T., Naimark M.D., Kiani M.F., Merchant T.E. Radiation-induced permeability and leukocyte adhesion in the rat blood-brain barrier: modulation with anti-ICAM-1 antibodies. Brain Res. 969:2003;59-69.
26. Zang Y., Leffler C.W. Compensatory role of NO in cerebral circulation of piglets chronically treated with indomethacin. Am. J. Physiol., Regul. Integr. Comp. Physiol. 282:2002;R400-R410.