Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke

Pediatric Research

Volumn 62, Issue 3, 2007, Pages 261-266

  Wang, Rong ^a   Ashwal, Stephen ^a   Tone, Beatriz ^a   Tian, Hou Rou ^a   Badaut, Jerome ^b   Rasmussen, Alison ^a   Obenaus, Andre ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN G; SODIUM CHLORIDE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HEMISPHERE; HISTOPATHOLOGY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEONATAL STROKE; NEUROIMAGING; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NEWBORN DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERMEABILITY; PRIORITY JOURNAL; RAT; REPERFUSION; STAINING; STROKE; WATER TRANSPORT;

ADULT; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; CEREBRAL INFARCTION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; NEUROPROTECTIVE AGENTS; PERMEABILITY; RATS; RATS, INBRED SHR; SERUM ALBUMIN; STROKE;

EID: 34548131624     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318123f757     Document Type: Article

References (45)

1. Lynch JK, Nelson KB 2001 Epidemiology of perinatal stroke. Curr Opin Pediatr 13:499-505
2. Emerson TE Jr 1989 Unique features of albumin: a brief review. Crit Care Med 17:690-694
3. Belayev L, Busto R, Zhao W, Clemens J, Ginsberg M 1997 Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats. J Neurosurg 87:595-601
4. Belayev L, Zhao W, Pattany P, Weaver G, Huh P, Lin B, Busto R, Ginsberg M 1998 Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. Stroke 29:2587-2599
5. Huh PW, Belayev L, Zhao W, Busto R, Saul I, Ginsberg MD 1998 The effect of high-dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats. Brain Res 804:105-113
6. Belayev L, Liu Y, Weizhao Z, Busto R, Ginsberg M 2001 Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke 32:553-560
7. Heros RC, Korosue K 1989 Hemodilution for cerebral ischemia. Stroke 20:423-427
8. Cole DJ, Drummond JC, Patel PM, Marcantonio S 1994 Effects of viscosity and oxygen content on cerebral blood flow in ischemic and normal rat brain. J Neurol Sci 124:15-20
9. Belayev L, Saul I, Busto R, Danielyan K, Vigdorchik A, Khoutorova L, Ginsberg MD 2005 Albumin treatment reduces neurological deficit and protects blood-brain barrier integrity after acute intracortical hematoma in the rat. Stroke 36:326-331
10. Halliwell B, Gutteridge JM 1990 The antioxidants of human extracellular fluids. Arch Biochem Biophys 280:1-8
11. Rodriguez de Turco EB, Belayev L, Liu Y, Busto R, Parkins N, Bazan NG, Ginsberg MD 2002 Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. J Neurochem 83:515-524
12. Keaney JF Jr, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J 1993 NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest 91:1582-1589
13. Tabernero A, Medina A, Sanchez-Abarca LI, Lavado E, Medina JM 1999 The effect of albumin on astrocyte energy metabolism is not brought about through the control of cytosolic Ca2-+ concentrations but by free-fatty acid sequestration. Glia 25:1-9
14. Ginsberg MD, Hill MD, Palesch YY, Ryckborst KJ, Tamariz D 2006 The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke. I: Physiological responses and safety results. Stroke 37:2100-2106
15. Palesch YY, Hill MD, Ryckborst KJ, Tamariz D, Ginsberg MD 2006 The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke. II: Neurologic outcome and efficacy analysis. Stroke 37:2107-2114
16. Ginsberg MD, Palesch YY, Hill MD 2006 The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report. Biochem Soc Trans 34:1323-1326
17. Greenough A 1998 Use and misuse of albumin infusions in neonatal care. Eur J Pediatr 157:699-702
18. Uhing MR 2004 The albumin controversy. Clin Perinatol 31:475-488
19. Evans N 2003 Volume expansion during neonatal intensive care: do we know what we are doing? Semin Neonatol 8:315-323
20. Ashwal S, Cole DJ, Osborne S, Osborne TN, Pearce WJ 1995 A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat pup. Pediatr Neurol 12:191-196
21. Ashwal S, Tone B, Tian HR, Chong S, Obenaus A 2006 Serial magnetic resonance imaging in a rat pup filament stroke model. Exp Neurol 202:294-301
22. Bartnik BL, Kendall EJ, Obenaus A 2001 Cortical devascularization: quantitative diffusion weighted magnetic resonance imaging and histological findings. Brain Res 915:133-142
23. De Ryck M, Van Reempts J, Borgers M, Wauquier A, Janssen PA 1989 Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats. Stroke 20:1383-1390
24. Moser VC 1998 EPA/AIHC Training video and reference manual for a functional observational battery. Joseph F. Ross, Proctor U.S. Environmental Protection Agency
25. Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, Riyamongkol P, Zhao W, Busto R, Ginsberg MD 2002 Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses. Stroke 33:1077-1084
26. Belayev L, Saul I, Huh PW, Finotti N, Zhao W, Busto R, Ginsberg MD 1999 Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats. Brain Res 845:107-111
27. Belayev L, Busto R, Zhao W, Ginsberg MD 1996 Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 739:88-96
28. Zoellner H, Hofler M, Beckmann R, Hufnagl P, Vanyek E, Bielek E, Wojta J, Fabry A, Lockie S, Binder BR 1996 Serum albumin is a specific inhibitor of apoptosis in human endothelial cells. J Cell Sci 109:2571-2580
29. Schnitzer JE, Sung A, Horvat R, Bravo J 1992 Preferential interaction of albumin-binding proteins, gp30 and gp18, with conformationally modified albumins. Presence in many cells and tissues with a possible role in catabolism. J Biol Chem 267:24544-24553
30. Antohe F, Dobrila L, Heltianu C, Simionescu N, Simionescu M 1993 Albumin-binding proteins function in the receptor-mediated binding and transcytosis of albumin across cultured endothelial cells. Eur J Cell Biol 60:268-275
31. Wasil M, Halliwell B, Hutchison DC, Baum H 1987 The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of alpha 1-antiproteinase by hypochlorous acid and by hydrogen peroxide. Biochem J 243:219-223
32. Halliwell B 1988 Albumin - an important extracellular antioxidant? Biochem Pharmacol 37:569-571
33. Curry S, Mandelkow H, Brick P, Franks N 1998 Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol 5:827-835
34. Trigatti BL, Gerber GE 1995 A direct role for serum albumin in the cellular uptake of long-chain fatty acids. Biochem J 308:155-159
35. Koch-Weser J, Sellers EM 1976 Binding of drugs to serum albumin (first of two parts). N Engl J Med 294:311-316
36. Menzies SA, Hoff JT, Betz AL 1990 Extravasation of albumin in ischaemic brain oedema. Acta Neurochir Suppl (Wien) 51:220-222
37. Kuroiwa T, Shibutani M, Okeda R 1988 Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia. Acta Neuropathol (Berl) 76:62-70
38. Young W, Rappaport ZH, Chalif DJ, Flamm ES 1987 Regional brain sodium, potassium, and water changes in the rat middle cerebral artery occlusion model of ischemia. Stroke 18:751-759
39. Hatashita S, Hoff JT 1990 Brain edema and cerebrovascular permeability during cerebral ischemia in rats. Stroke 21:582-588
40. Tuor UI, Chumas PD, Del Bigio MR 1995 Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting. Exp Neurol 132:116-122
41. Muramatsu K, Fukuda A, Togari H, Wada Y, Nishino H 1997 Vulnerability to cerebral hypoxic-ischemic insult in neonatal but not in adult rats is in parallel with disruption of the blood-brain barrier. Stroke 28:2281-2288
42. Yang GY, Betz AL 1994 Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25:1658-1664
43. Abraham CS, Harada N, Deli MA, Niwa M 2002 Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats. Cell Mol Neurobiol 22:455-462
44. Qiao M, Malisza KL, Del Bigio MR, Tuor UI 2001 Correlation of cerebral hypoxic-ischemic T2 changes with tissue alterations in water content and protein extravasation. Stroke 32:958-963
45. Memezawa H, Smith ML, Siesjo BK 1992 Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559