3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 5, 2009, Pages 1434-1437

  Biju, Purakkattle ^a   Taveras, Arthur G ^a   Yu, Younong ^a   Zheng, Junying ^a   Hipkin, R William ^a   Fossetta, James ^a   Fan, Xuedong ^a   Fine, Jay ^a   Lundell, Daniel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

3,4 Diamino 1,2,5 thiadiazoles; CXCR2 receptor antagonist

Indexed keywords

3,4 DIAMINO 1,2,5 THIADIAZOLE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY;

DIAMINES; HUMANS; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 60449084221     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.027     Document Type: Article

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