Basis for structural diversity in homologous RNAs

Science

Volumn 306, Issue 5693, 2004, Pages 104-107

  Krasilnikov, Andrey S ^a   Xiao, Yinghua ^a   Pan, Tao ^b   Mondragon, Alfonso ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; GENETIC ENGINEERING; RNA;

AUXILIARY ELEMENTS; RIBOZYMES; STRUCTURAL DIVERSITY; TERTIARY FOLDS;

MOLECULAR STRUCTURE;

RIBONUCLEASE P; RIBOZYME; RNA; BACTERIAL RNA; RIBONUCLEOTIDE; RNA PRECURSOR; TRANSFER RNA;

RNA;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; ENZYMOLOGY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PHYLOGENY; RIBONUCLEASE P; RIBONUCLEOTIDES; RNA PRECURSORS; RNA, BACTERIAL; RNA, TRANSFER; THERMUS THERMOPHILUS;

EID: 6044275739     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101489     Document Type: Article

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26. We thank C. Correll, E. Sontheimer, A. Torres, O. Uhlenbeck, J. Wedekind, and B. Wurzburg for comments and suggestions. We thank members of DuPont-Northwestern-Dow Collaborative Access Team (DND-CAT) for help with data collection. Research was supported by NIH (A.M.) and an NIH National Research Service Award Fellowship (A.K.). We acknowledge support from the R.H. Lurie Cancer Center of Northwestern University to the Structural Biology Center. Portions of this work were performed at the DND-CAT Synchrotron Research Center at the Advanced Photon Source (APS). DND-CAT is supported by DuPont, Dow, and NSF and use of the APS is supported by the U.S. Department of Energy. Coordinates and structure factors have been deposited in the Protein Data Bank under the accession code 1U9S.