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Volumn 70, Issue 3, 2009, Pages 439-445

Use of a GH receptor antagonist (GHRA) to explore the relationship between GH and IGF-I in adults with severe GH deficiency (GHD)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GROWTH HORMONE; PEGVISOMANT; PLACEBO; SOMATOMEDIN C;

EID: 60349122807     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03481.x     Document Type: Article
Times cited : (9)

References (36)
  • 1
    • 0030744020 scopus 로고    scopus 로고
    • Insulin-like growth factor-I in growth hormone-deficient adults: Relationship to population-based normal values, body composition and insulin tolerance test
    • Svensson, J., Johannsson, G. Bengtsson, B.A. (1997) Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal values, body composition and insulin tolerance test. Clinical Endocrinology, 46, 579 586.
    • (1997) Clinical Endocrinology , vol.46 , pp. 579-586
    • Svensson, J.1    Johannsson, G.2    Bengtsson, B.A.3
  • 2
    • 0029932234 scopus 로고    scopus 로고
    • Gender differences in secretory activity of the human somatotropic (growth hormone) axis
    • Veldhuis, J.D. (1996) Gender differences in secretory activity of the human somatotropic (growth hormone) axis. European Journal of Endocrinology, 134, 287 295.
    • (1996) European Journal of Endocrinology , vol.134 , pp. 287-295
    • Veldhuis, J.D.1
  • 3
    • 14044272879 scopus 로고    scopus 로고
    • Insulin-Like Growth Factor-I Response to a Single Bolus of Growth Hormone Is Increased in Obesity
    • Gleeson, H.K., Lissett, C.A. Shalet, S.M. (2005) Insulin-Like Growth Factor-I Response to a Single Bolus of Growth Hormone Is Increased in Obesity. Journal of Clinical Endocrinology and Metabolism, 90, 1061 1067.
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 1061-1067
    • Gleeson, H.K.1    Lissett, C.A.2    Shalet, S.M.3
  • 4
    • 0025347581 scopus 로고
    • The relationship between insulin-like growth factor-I, adiposity, and aging
    • Copeland, K.C., Colletti, R.B., Devlin, J.T. et al. (1990) The relationship between insulin-like growth factor-I, adiposity, and aging. Metabolism, 39, 584 587.
    • (1990) Metabolism , vol.39 , pp. 584-587
    • Copeland, K.C.1    Colletti, R.B.2    Devlin, J.T.3
  • 5
    • 0029964173 scopus 로고    scopus 로고
    • Serum growth hormone-binding protein in obesity: Effect of a short-term, very low calorie diet and diet-induced weight loss
    • Rasmussen, M.H., Ho, K.K., Kjems, L. et al. (1996) Serum growth hormone-binding protein in obesity: effect of a short-term, very low calorie diet and diet-induced weight loss. Journal of Clinical Endocrinology and Metabolism, 81, 1519 1524.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 1519-1524
    • Rasmussen, M.H.1    Ho, K.K.2    Kjems, L.3
  • 6
    • 0023949155 scopus 로고
    • Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man
    • Ho, K.Y., Veldhuis, J.D., Johnson, M.L. et al. (1988) Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. Journal of Clinical Investigation, 81, 968 975.
    • (1988) Journal of Clinical Investigation , vol.81 , pp. 968-975
    • Ho, K.Y.1    Veldhuis, J.D.2    Johnson, M.L.3
  • 7
    • 0034896661 scopus 로고    scopus 로고
    • Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency
    • Maccario, M., Aimaretti, G., Grottoli, S. et al. (2001) Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency. International Journal of Obesity-Related Metabolic Disorders, 25, 1233 1239.
    • (2001) International Journal of Obesity-Related Metabolic Disorders , vol.25 , pp. 1233-1239
    • MacCario, M.1    Aimaretti, G.2    Grottoli, S.3
  • 8
    • 33644828674 scopus 로고    scopus 로고
    • The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency
    • Darzy, K.H., Murray, R.D., Gleeson, H.K. et al. (2006) The impact of short-term fasting on the dynamics of 24-hour growth hormone (GH) secretion in patients with severe radiation-induced GH deficiency. Journal of Clinical Endocrinology and Metabolism, 91, 987 994.
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , pp. 987-994
    • Darzy, K.H.1    Murray, R.D.2    Gleeson, H.K.3
  • 10
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Rosen, T. Bengtsson, B.-A. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, 336, 285 288.
    • (1990) Lancet , vol.336 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.-A.2
  • 11
    • 0035835469 scopus 로고    scopus 로고
    • Association between premature mortality and hypopituitarism. West midlands prospective hypopituitary study group
    • Tomlinson, J.W., Holden, N., Hills, R.K. et al. (2001) Association between premature mortality and hypopituitarism. West midlands prospective hypopituitary study group. Lancet, 357, 425 431.
    • (2001) Lancet , vol.357 , pp. 425-431
    • Tomlinson, J.W.1    Holden, N.2    Hills, R.K.3
  • 12
    • 0033345441 scopus 로고    scopus 로고
    • The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients
    • Gibney, J., Wallace, J.D., Spinks, T. et al. (1999) The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients. Journal of Clinical Endocrinology and Metabolism, 84, 2596 2602.
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 2596-2602
    • Gibney, J.1    Wallace, J.D.2    Spinks, T.3
  • 13
    • 0034749231 scopus 로고    scopus 로고
    • A prospective study of 5 years of GH replacement therapy in GH deficient adults: Sustained effects on body composition, bone mass, and the metabolic indices
    • Gotherstrom, G., Svensson, J., Koranyi, J. et al. (2001) A prospective study of 5 years of GH replacement therapy in GH deficient adults: sustained effects on body composition, bone mass, and the metabolic indices. Journal of Clinical Endocrinology and Metabolism, 86, 4657 4665.
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 4657-4665
    • Gotherstrom, G.1    Svensson, J.2    Koranyi, J.3
  • 14
    • 0033785295 scopus 로고    scopus 로고
    • Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: A two year study
    • Florakis, D., Hung, V., Kaltsas, G. et al. (2000) Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study. Clinical Endocrinology, 53, 453 459.
    • (2000) Clinical Endocrinology , vol.53 , pp. 453-459
    • Florakis, D.1    Hung, V.2    Kaltsas, G.3
  • 15
    • 4644351107 scopus 로고    scopus 로고
    • Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: Screening study at 3 months after the brain injury
    • Aimaretti, G., Ambrosio, M.R., Di Somma, C. et al. (2004) Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury. Clinical Endocrinology, 61, 320 326.
    • (2004) Clinical Endocrinology , vol.61 , pp. 320-326
    • Aimaretti, G.1    Ambrosio, M.R.2    Di Somma, C.3
  • 16
    • 0031792510 scopus 로고    scopus 로고
    • Consensus Guidelines for the Diagnosis and Treatment of Adults with Growth Hormone Deficiency: Summary Statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency
    • No authors listed (
    • No authors listed (1998) Consensus Guidelines for the Diagnosis and Treatment of Adults with Growth Hormone Deficiency: Summary Statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. Journal of Clinical Endocrinology and Metabolism, 83, 379 381.
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , pp. 379-381
  • 17
    • 0346732359 scopus 로고    scopus 로고
    • Seeking the optimal target range for insulin-like growth factor i during the treatment of adult growth hormone disorders
    • Mukherjee, A., Monson, J.P., Jonsson, P.J. et al. (2003) Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders. Journal of Clinical Endocrinology and Metabolism, 88, 5865 5870.
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , pp. 5865-5870
    • Mukherjee, A.1    Monson, J.P.2    Jonsson, P.J.3
  • 18
    • 0035944825 scopus 로고    scopus 로고
    • Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
    • Van der Lely, A.J., Hutson, R.K., Trainer, P.J. et al. (2001) Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet, 358, 1754 1759.
    • (2001) Lancet , vol.358 , pp. 1754-1759
    • Van Der Lely, A.J.1    Hutson, R.K.2    Trainer, P.J.3
  • 19
    • 0025335293 scopus 로고
    • Two-site and competitive chemiluminescent immunoassays
    • Strasburger, C.J. Kohen, F. (1990) Two-site and competitive chemiluminescent immunoassays. Methods Enzymology, 184, 481 496.
    • (1990) Methods Enzymology , vol.184 , pp. 481-496
    • Strasburger, C.J.1    Kohen, F.2
  • 20
    • 0033305394 scopus 로고    scopus 로고
    • Growth hormone (GH) receptor blocade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not actually stimulate serum GH
    • Thorner, M.O., Strasburger, C.J., Wu, Z. et al. (1999) Growth hormone (GH) receptor blocade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not actually stimulate serum GH. Journal of Clinical Endocrinology and Metabolism, 84, 2098 2103.
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 2098-2103
    • Thorner, M.O.1    Strasburger, C.J.2    Wu, Z.3
  • 21
    • 0025723443 scopus 로고
    • Ligand mediated immunofunctional assay for quantification of growth hormone-binding protein in human blood
    • Carlsson, L.M., Rowland, A.M., Clark, R.G. et al. (1991) Ligand mediated immunofunctional assay for quantification of growth hormone-binding protein in human blood. Journal of Clinical Endocrinology and Metabolism, 73, 1216 1223.
    • (1991) Journal of Clinical Endocrinology and Metabolism , vol.73 , pp. 1216-1223
    • Carlsson, L.M.1    Rowland, A.M.2    Clark, R.G.3
  • 22
    • 10744225758 scopus 로고    scopus 로고
    • Serum insulin-like growth factor-I reference values for an automated chemiluminiscence immunoassay system: Results from a multicenter study
    • Von zur Muhlen
    • Brabant, G., Von zur Muhlen, Wuster, C. et al. (2003) Serum insulin-like growth factor-I reference values for an automated chemiluminiscence immunoassay system: results from a multicenter study. Hormone Research, 60 (Suppl. 2 53 60.
    • (2003) Hormone Research , vol.602 , pp. 53-60
    • Brabant, G.1    Wuster, C.2
  • 23
    • 0031885373 scopus 로고    scopus 로고
    • Standardization of BMD measurements
    • Formica, C.A. (1998) Standardization of BMD measurements. Osteoporos International, 8 1 3.
    • (1998) Osteoporos International , vol.8 , pp. 1-3
    • Formica, C.A.1
  • 24
    • 0034926532 scopus 로고    scopus 로고
    • Lowering total plasma insulin-like growth factor i concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men
    • Veldhuis, J.D., Bidlingmaier, M., Anderson, S.M. et al. (2001) Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men. Journal of Clinical Endocrinology and Metabolism, 86, 3304 3310.
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 3304-3310
    • Veldhuis, J.D.1    Bidlingmaier, M.2    Anderson, S.M.3
  • 25
    • 34447135520 scopus 로고    scopus 로고
    • Clinical implications of residual growth hormone (GH) response to provocative testing in adults with severe GH deficiency
    • Brabant, G., Krogh Rasmussen, A., Biller, B.M. et al. (2007) Clinical implications of residual growth hormone (GH) response to provocative testing in adults with severe GH deficiency. Journal of Clinical Endocrinology and Metabolism, 92, 2604 2609.
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 2604-2609
    • Brabant, G.1    Krogh Rasmussen, A.2    Biller, B.M.3
  • 26
    • 33847392443 scopus 로고    scopus 로고
    • Clinical pharmacodynamic effect of the growth hormone receptor antagonist pegvisomant: Implications for cancer therapy
    • Yin, D., Vreeland, F., Shaaf, L.J. et al. (2007) Clinical pharmacodynamic effect of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. Clinical Cancer Research, 13, 1000 1009.
    • (2007) Clinical Cancer Research , vol.13 , pp. 1000-1009
    • Yin, D.1    Vreeland, F.2    Shaaf, L.J.3
  • 27
    • 0029835895 scopus 로고    scopus 로고
    • Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3
    • Harrela, M., Koistinen, H., Kaprio, J. et al. (1996) Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. Journal of Clinical Investigation, 98, 2612 2615.
    • (1996) Journal of Clinical Investigation , vol.98 , pp. 2612-2615
    • Harrela, M.1    Koistinen, H.2    Kaprio, J.3
  • 28
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: Biological actions
    • Jones, J.I. Clemmons, D.R. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocrine Review, 16, 3 34.
    • (1995) Endocrine Review , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 29
    • 0031442972 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins in serum and other biological fluids: Regulation and functions
    • Rajaram, S., Baylink, D.J. Mohan, S. (1997) Insulin-like growth factor binding proteins in serum and other biological fluids: regulation and functions. Endocrine Review, 18, 801 831.
    • (1997) Endocrine Review , vol.18 , pp. 801-831
    • Rajaram, S.1    Baylink, D.J.2    Mohan, S.3
  • 30
    • 0033304507 scopus 로고    scopus 로고
    • The insulin-like growth factor binding protein (IGFBP) superfamily
    • Hwa, V., Oh, Y. Rosenfeld, R.G. (1999) The insulin-like growth factor binding protein (IGFBP) superfamily. Endocrine Review, 20, 761 787.
    • (1999) Endocrine Review , vol.20 , pp. 761-787
    • Hwa, V.1    Oh, Y.2    Rosenfeld, R.G.3
  • 31
    • 0029961064 scopus 로고    scopus 로고
    • Monitoring of growth hormone replacement therapy in adults based on measurement of serum markers
    • De Boer, H., Blok, G.J., Popp-Snijders, C. et al. (1996) Monitoring of growth hormone replacement therapy in adults based on measurement of serum markers. Journal of Clinical Endocrinology and Metabolism, 81, 1371 1377.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 1371-1377
    • De Boer, H.1    Blok, G.J.2    Popp-Snijders, C.3
  • 32
    • 0033304486 scopus 로고    scopus 로고
    • Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life
    • Aguiar-Oliveira, M.H., de Gill, M.S.A., Barretto, E.S. et al. (1999) Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. Journal of Clinical Endocrinology and Metabolism, 84, 4118 4126.
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 4118-4126
    • Aguiar-Oliveira, M.H.1    De Gill, M.S.A.2    Barretto, E.S.3
  • 33
    • 0034799545 scopus 로고    scopus 로고
    • Monitoring of treatment success in patients with acromegaly: The value of serum insulin-like growth factor binding protein-3 and serum leptin measurements in comparison to plasma insulin-like growth factor i determination
    • Páramo, C., Fluiters, E., de la Fuente, J. et al. (2001) Monitoring of treatment success in patients with acromegaly: the value of serum insulin-like growth factor binding protein-3 and serum leptin measurements in comparison to plasma insulin-like growth factor I determination. Metabolism, 50, 1117 1121.
    • (2001) Metabolism , vol.50 , pp. 1117-1121
    • Páramo, C.1    Fluiters, E.2    De La Fuente, J.3
  • 34
    • 0034520154 scopus 로고    scopus 로고
    • Tumor necrosis factor-α converting enzyme (TACE) is a GHBP sheddase: The metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation
    • Zhang, Y., Jiang, J., Black, R.A. et al. (2000) Tumor necrosis factor-α converting enzyme (TACE) is a GHBP sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation. Endocrinology, 141, 4342 4348.
    • (2000) Endocrinology , vol.141 , pp. 4342-4348
    • Zhang, Y.1    Jiang, J.2    Black, R.A.3
  • 35
    • 32944465568 scopus 로고    scopus 로고
    • Growth hormone-binding protein (GHBP)
    • Katsumata, N. (2005) Growth hormone-binding protein (GHBP). Nippon Rinsho, 63 (Suppl. 8 183 185.
    • (2005) Nippon Rinsho , vol.638 , pp. 183-185
    • Katsumata, N.1
  • 36
    • 0035040522 scopus 로고    scopus 로고
    • Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimmer
    • Ross, R.J.M., Leung, K.C., Maamra, M. et al. (2001) Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimmer. Journal of Clinical Endocrinology and Metabolism, 86, 1716 1723.
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 1716-1723
    • Ross, R.J.M.1    Leung, K.C.2    Maamra, M.3


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