Culture nutrition and physiology impact the inhibitor tolerance of the yeast Pichia stipitis NRRL Y-7124

Biotechnology and Bioengineering

Volumn 102, Issue 3, 2009, Pages 778-790

  Slininger, Patricia J ^a   Gorsich, Steven W ^b   Liu, Zonglin L ^a  

^a NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

^b CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

5 hydroxymethylfur fural; Amino acids; Ethanol; Furan methanol; Furan 2,5 dimethanol; Furfural; Lignocellulose hydrolysate fermentation; Minerals; Viable cell survival

Indexed keywords

5-HYDROXYMETHYLFUR-FURAL; FURAN METHANOL; FURAN-2,5-DIMETHANOL; LIGNOCELLULOSE HYDROLYSATE FERMENTATION; VIABLE CELL SURVIVAL;

ALDEHYDES; AMINATION; AMINES; AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOMASS; CELL CULTURE; CELLULOSE; CHEMICAL ANALYSIS; CHROMATOGRAPHIC ANALYSIS; DETOXIFICATION; ETHANOL; FERMENTATION; FURFURAL; GLUCOSE; IMPACT RESISTANCE; LIGNIN; MAGNESIUM; METHANOL; MINERALOGY; ORGANIC ACIDS; PROCESS ENGINEERING; RENEWABLE ENERGY RESOURCES; SILICA; SILICATE MINERALS; YEAST;

MINERALS;

5 HYDROXYMETHYLFURFURAL; ALCOHOL; AMINO ACID; CARBON; FURFURAL; GLUCOSE; LIGNOCELLULOSE; MAGNESIUM SULFATE; METHANOL DERIVATIVE; MINERAL; NITROGEN; PROTEIN HYDROLYSATE; XYLOSE;

ALCOHOL PRODUCTION; ALCOHOL TOLERANCE; ARTICLE; BIOFUEL PRODUCTION; BIOMASS CONVERSION; BIOMASS FERMENTATION; CARBON SOURCE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CULTURE MEDIUM; CULTURE OPTIMIZATION; DETOXIFICATION; FUNGAL BIOMASS; FUNGAL CELL CULTURE; FUNGUS GROWTH; GROWTH INHIBITION; NONHUMAN; NUTRITIONAL TOLERANCE; PICHIA STIPITIS; YEAST CELL;

AMINO ACIDS; ANALYSIS OF VARIANCE; BIOMASS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; ETHANOL; FERMENTATION; FURALDEHYDE; GLUCOSE; LIGNIN; MINERALS; NITROGEN; PICHIA; XYLOSE;

PICHIA STIPITIS;

EID: 60349106674     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22110     Document Type: Article

References (47)

1. Alexandre H, Rousseaux I, Charpentier C. 1993. Ethanol adaptation mechanisms in Saccharomyces cerevisiae. Biotechnol Appl Biochem 20:173-183.
2. Bruinenberg PM, deBot PHM, Van Dijken JP, Scheffers WA. 1984. NADH-linked aldose reductase: The key to anaerobic alcoholic fermentation of xylose by yeasts. Appl Microbiol Biotechnol 19:256-260.
3. Casey GP, Magnus CA, Ingledew WM. 1984. High-gravity brewing: Effects of nutrition on yeast composition, fermentative ability, and alcohol production. Appl Environ Microbiol 48:639-646.
4. Chen C, Dickman MB. 2005. Proline suppresses apoptosis in the fungal Colletotrichum trifolii. PNAS 102:3459-3464.
5. Devantier R, Pedersen S, Olsson L. 2005. Transcription analysis of S. cerevisiae in VHG fermentation: The genome-wide transcriptional response of Saccharomyces cerevisiae during very high gravity ethanol fermentations is highly affected by the stationary phase. Ind Biotechnol 1:51-63.
6. Dombek KM, Ingram LO. 1986. Magnesium limitation and its role in apparent toxicity of ethanol during yeast fermentation. Appl Environ Microbiol 52:975-981.
7. du Preez JC, Van Driessel B, Prior BA. 1989. Ethanol tolerance of Pichia stipitis and Candida shehatae strains in fed-batch cultures at controlled low dissolved oxygen levels. Appl Microbiol Biotechnol 30:53-58.
8. Girbes T, Parrilla R. 1983. Effect of ethanol on the uptake and utilization of nutrients by alcohol-resistant yeasts. Cell Mol Biol 29:443-449.
9. Girbes T, Parrilla R. 1986. Correlation between ethanol resistance and incorporation of nutrients by must fermenting yeast. Cell Mol Biol 32:545-549.
10. Gorsich SW, Dien BS, Nichols NN, Slininger PJ, Liu ZL, Skory CD. 2006. Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 71:339-349.
11. Horvath IS, Franzén CJ, Taherzadeh MJ, Niklasson C, Lidén G. 2003. Effects of furfural on the respiratory metabolism of Saccharomyces cerevisiae in glucose-limited chemostats. Appl Environ Microbiol 69:4076-4086.
12. Jasper P, Silver S. 1977. Chapter 1 magnesium transport in microorganisms. In: Weinberg ED, editor. Microorganisms and minerals, microorganisms and minerals. Marcel Dekker, Inc. p 8-12.
13. Jeffries TW, Grigoriev IV, Grimwood J, Laplaza JM, Aerts A, Salamov A, Schmutz J, Lindquist E, Dehal P, Shapiro H, Jin Y, Passoth V, Richardson PM. 2007. Genome sequence of the lignocellulose-biocon-verting and xylose-fermenting yeast Pichia stipitis. Nat Biotechnol 25:319-326.
14. Jones RP. 1989. Biological principles for the effects of ethanol. Enzyme Microb Technol 11:130-153.
15. Jones RP, Greenfield PE. 1987. Ethanol and the fluidity of the yeast plasma membrane. Yeast 3:223-232.
16. Larroy C, Fernandez MR, Gonzalez E, Pares X, Biosca JA. 2002. Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene pro
17. duct as a broad specificity NADPH-dependent alcohol dehydrogenase: Relevance in aldehyde reduction. Biochem J 361:163-172.
18. Larssen S, Palmqvist E, Hahn-Hagerdal B, Tengborg C, Stenberg K, Zacchi G, Nilvebrant NO. 1998. The generation of fermentation inhibitors during dilute acid hydrolysis of softwood. Enzyme Microb Technol 24:151-159.
19. Liu ZL, Slininger PJ, Dien BS, Berhow MA, Kurtzman CP, Gorsich SW. 2004. Adaptive response of yeasts to furfural and 5-hydroxymethyl-furfural and new chemical evidence for HMF conversion to 2,5-bis-hydroxymethylfuran. J Ind Microbiol Biotechnol 31:345-352.
20. Liu ZL, Slininger PJ, Gorsich SW. 2005. Enhanced biotransformation of furfural and hydroxymethylfurfural by newly developed ethanologenic yeast strains. Appl Biochem Biotechnol 121-124:451-460.
21. Mauricio JC, Valero E, Millan C, Ortega JM. 2001. Changes in nitrogen compounds in must and wine during fermentation and biological aging by flor yeasts. J Agric Food Chem 49:3310-3315.
22. Modig T, Lidén G, Taherzadeh MJ. 2002. Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase. Biochem J 363:769-776.
23. Morimoto S, Murakami M. 1967. Studies on fermentation products from aldehyde by microorganisms: The fermentative production of furfural alcohol from furfural by yeasts (part I). J Ferment Technol 45:442-446.
24. Nemirovskii VD, Kostenko VG. 1991. Transformation of yeast growth inhibitors, which occurs during biochemical processing of wood hydolysates. Gidroliz Lesokhim Prom-st 1:16-17.
25. Nemirovskii VD, Gusarova LA, Rakhmilevich Ya D, Sizov AI, Kostenko VG. 1989. Furfurol and hydroxymethylfurfurol transformation routes during culturing of nutrient yeasts. Biotekhnologiya 5:285-289.
26. Nilsson A, Gorwa-Grauslund MF, Hahn-Hägerdal B, Liden G. 2005. Cofactor dependence in furan reduction by Saccharomyces cerevisiae in fermentation of acid-hydrolyzed lignocellulose. Appl Environ Microbiol 71:7866-7871.
27. O'Connor-Cox ESC, Paik J, Ingledew WM. 1991. Improved ethanol yields through supplementation with excess assimilable nitrogen. J Ind Microbiol 8:45-52.
28. Palmqvist E, Hahn-Haagerdal B. 2000. Fermentation of lignocellulosic hydrolysates. II. Inhibitors and mechanisms of inhibition. Bioresource Technol 74:25-33.
29. Palmqvist E, Almeida J, Hahn-Hagerdal B. 1999. Influence of furfural on anaerobic glycolytic kinetics of Saccharomyces cerevisiae in batch culture. Biotechnol Bioeng 62:447-454.
30. Perlack RD, Wright LL, Turhollow AF, Graham RL, Stokes BJ, Erbach DC. 2005. Biomass as feedstock for a bioenergy and bioproducts industry: The technical feasibility of a billion-ton annual supply. U.S. Department of Energy and U.S. Department of Agriculture. http://www1.eere.energy.gov/biomass/pdfs/ final-billionton-vision-report2.pdf.
31. Petersson A, Almeida JRM, Modig T, Karhumaa K, Hahn-Hagerdal B, Gorwa-Grauslund MF, Liden G. 2006. A 5-hydroxymethyl furfural
32. reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast 23:455-464.
33. Prior BA, Kilian SG, du Preez JC. 1989. Fermentation of D-xylose by the yeasts Candida shehatae and Pichia stipitis. Proc Biochem February 21-32.
34. Sajbidor J. 1997. Effect of some environmental factors on the content and composition of microbial membrane lipids. Crit Rev Biotechnol 17:87-103.
35. Sajbidor J, Grego J. 1992. Fatty acid alterations in Saccharomyces cerevisiae exposed to ethanol stress. FEMS Microbiol Lett 93:13-16.
36. Sanchez B, Bautista J. 1988. Effects of furfural and 5- hydroxymethylfurfural on the fermentation of Saccharomyces cerevisiae and biomass production from Candida guillermondii. Enzyme Microb Technol 10:315-318.
37. Slininger PJ, Bothast RJ, Okos MR, Ladisch MR. 1985. Comparative evaluation of ethanol production by xylose-fermenting yeasts presented high xylose concentrations. Biotechnol Lett 7:431-436.
38. Slininger PJ, Branstrator LE, Lomont JM, Dien BS, Okos MR, Ladisch MR, Bothast RJ. 1990a. Stoichiometry and kinetics of xylose fermentation by Pichia stipitis. Ann NY Acad Sci 589:25-40.
39. Slininger PJ, Bothast RJ, Ladisch MR, Okos MR. 1990b. Optimum pH and temperature conditions for xylose fermentation by Pichia stipitis. Biotechnol Bioeng 35:727-731.
40. Slininger PJ, Branstrator LE, Bothast RJ, Okos MR, Ladisch MR. 1991. Growth, death, and oxygen uptake kinetics of Pichia stipitis on xylose. Biotechnol Bioeng 37:973-980.
41. Slininger PJ, Dien BS, Gorsich SW, Liu ZL. 2006. Nitrogen source and mineral optimization enhance D-xylose conversion to ethanol by the yeast Pichia stipitis NRRL Y-7124. Appl Microbiol Biotechnol 72:1285-1296.
42. Taherzadeh MJ, Gustafsson L, Niklasson C, Lidén G. 1999a. Conversion of furfural in aerobic and anaerobic batch fermentation of glucose by Saccharomyces cerevisiae. J Biosci Bioeng 87:169-174.
43. Taherzadeh MJ, Niklasson C, Lidén G. 1999b. Conversion of dilute-acid hydrolyzates of spruce and birch to ethanol by fed-batch fermentation. Bioresource Technol 69:59-66.
44. Taherzadeh MJ, Gustafsson L, Niklasson C, Lidén G. 2000. Physiological effects of 5-hydroxymethylfurfural on Saccharomyces cerevisiae. Appl Microbiol Biotechnol 53:701-708.
45. Viegas CA, Sa-Correia I, Novais JM. 1985. Nutrient-enhanced production of remarkably high concentrations of ethanol by Saccharomyces cerevisiae through soy flour supplementation. Appl Environ Microbiol 50:1333-1335.
46. Villa GP, Bartroli R, Lopez R, Guerra M, Enrique M, Penas M, Rodriquez E, Redondo D, Iglesias I, Diaz M. 1992. Microbial transformation of furfural to furfuryl alcohol by Saccharomyces cerevisiae. Acta Biotechnol 12:509-512.
47. Weigert B, Klein C, Rizzi M, Lauterbach C, Dellweg H. 1988. Xylose fermentation by yeasts. 8. Influence of furfural on the aerobic growth of the yeast Pichia stipitis. Biotechnol Lett 10:895-900.