-
1
-
-
0025790437
-
Identification and characterization of the neurofibromatosis type 1 protein product
-
DeClue J.E., Cohen B.D., and Lowy D.R. Identification and characterization of the neurofibromatosis type 1 protein product. Proc. Natl. Acad. Sci. USA 88 (1991) 9914-9918
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 9914-9918
-
-
DeClue, J.E.1
Cohen, B.D.2
Lowy, D.R.3
-
4
-
-
0004042176
-
-
Johns Hopkins University Press, Baltimore, Maryland
-
Friedman J.M., Gutmann D.H., MacCollin M., and Riccardi V.M. Neurofibromatosis: Phenotype, Natural History, and Pathogenesis (1999), Johns Hopkins University Press, Baltimore, Maryland
-
(1999)
Neurofibromatosis: Phenotype, Natural History, and Pathogenesis
-
-
Friedman, J.M.1
Gutmann, D.H.2
MacCollin, M.3
Riccardi, V.M.4
-
5
-
-
0035936783
-
NF1 tumor suppressor gene function: narrowing the GAP
-
Cichowski K., and Jacks T. NF1 tumor suppressor gene function: narrowing the GAP. Cell 104 (2001) 593-604
-
(2001)
Cell
, vol.104
, pp. 593-604
-
-
Cichowski, K.1
Jacks, T.2
-
6
-
-
0035835817
-
Neurofibromin, a tumor suppressor in the nervous system
-
Zhu Y., and Parada L.F. Neurofibromin, a tumor suppressor in the nervous system. Exp. Cell Res. 264 (2001) 19-28
-
(2001)
Exp. Cell Res.
, vol.264
, pp. 19-28
-
-
Zhu, Y.1
Parada, L.F.2
-
8
-
-
0024376173
-
Ras oncogenes in human cancer: a review
-
Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49 (1989) 4682-4689
-
(1989)
Cancer Res.
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
10
-
-
0023619575
-
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
-
Trahey M., and McCormick F. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238 (1987) 542-545
-
(1987)
Science
, vol.238
, pp. 542-545
-
-
Trahey, M.1
McCormick, F.2
-
11
-
-
0024294392
-
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain
-
Adari H., Lowy D.R., Willumsen B.M., Der C.J., and McCormick F. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science 240 (1988) 518-521
-
(1988)
Science
, vol.240
, pp. 518-521
-
-
Adari, H.1
Lowy, D.R.2
Willumsen, B.M.3
Der, C.J.4
McCormick, F.5
-
12
-
-
0025729180
-
Differential regulation of rasGAP and neurofibromatosis gene product activities
-
Bollag G., and McCormick F. Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature 351 (1991) 576-579
-
(1991)
Nature
, vol.351
, pp. 576-579
-
-
Bollag, G.1
McCormick, F.2
-
13
-
-
0025201012
-
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
-
Ballester R., Marchuk D., Boguski M., Saulino A., Letcher R., Wigler M., and Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63 (1990) 851-859
-
(1990)
Cell
, vol.63
, pp. 851-859
-
-
Ballester, R.1
Marchuk, D.2
Boguski, M.3
Saulino, A.4
Letcher, R.5
Wigler, M.6
Collins, F.7
-
14
-
-
0025251137
-
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
-
Martin G.A., Viskochil D., Bollag G., McCabe P.C., Crosier W.J., Haubruck H., Conroy L., Clark R., O'Connell P., Cawthon R.M., et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63 (1990) 843-849
-
(1990)
Cell
, vol.63
, pp. 843-849
-
-
Martin, G.A.1
Viskochil, D.2
Bollag, G.3
McCabe, P.C.4
Crosier, W.J.5
Haubruck, H.6
Conroy, L.7
Clark, R.8
O'Connell, P.9
Cawthon, R.M.10
-
15
-
-
0025091465
-
The neurofibromatosis type 1 gene encodes a protein related to GAP
-
Xu G.F., O'Connell P., Viskochil D., Cawthon R., Robertson M., Culver M., Dunn D., Stevens J., Gesteland R., White R., et al. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 62 (1990) 599-608
-
(1990)
Cell
, vol.62
, pp. 599-608
-
-
Xu, G.F.1
O'Connell, P.2
Viskochil, D.3
Cawthon, R.4
Robertson, M.5
Culver, M.6
Dunn, D.7
Stevens, J.8
Gesteland, R.9
White, R.10
-
16
-
-
0030018796
-
Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin
-
Ahmadian M.R., Wiesmuller L., Lautwein A., Bischoff F.R., and Wittinghofer A. Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin. J. Biol. Chem. 271 (1996) 16409-16415
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16409-16415
-
-
Ahmadian, M.R.1
Wiesmuller, L.2
Lautwein, A.3
Bischoff, F.R.4
Wittinghofer, A.5
-
17
-
-
0030772378
-
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K., Ahmadian M.R., Kabsch W., Wiesmuller L., Lautwein A., Schmitz F., and Wittinghofer A. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277 (1997) 333-338
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmuller, L.4
Lautwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
18
-
-
0031231083
-
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
-
Ahmadian M.R., Stege P., Scheffzek K., and Wittinghofer A. Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat. Struct. Biol. 4 (1997) 686-689
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 686-689
-
-
Ahmadian, M.R.1
Stege, P.2
Scheffzek, K.3
Wittinghofer, A.4
-
19
-
-
0032479992
-
Structural analysis of the GAP-related domain from neurofibromin and its implications
-
Scheffzek K., Ahmadian M.R., Wiesmuller L., Kabsch W., Stege P., Schmitz F., and Wittinghofer A. Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J. 17 (1998) 4313-4327
-
(1998)
EMBO J.
, vol.17
, pp. 4313-4327
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wiesmuller, L.3
Kabsch, W.4
Stege, P.5
Schmitz, F.6
Wittinghofer, A.7
-
20
-
-
75749096541
-
-
M. Schmidt Ed, Wuerzburg, Karger
-
S. Welti, I. D'Angelo, K. Scheffzek, in: M. Schmidt (Ed.), Neurofibromatoses, vol 16, Wuerzburg, Karger, 2008.
-
(2008)
Neurofibromatoses
, vol.16
-
-
Welti, S.1
D'Angelo, I.2
Scheffzek, K.3
-
21
-
-
0033602422
-
Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling [letter]
-
Aravind L., Neuwald A.F., and Ponting C.P. Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling [letter]. Curr. Biol. 9 (1999) R195-197
-
(1999)
Curr. Biol.
, vol.9
-
-
Aravind, L.1
Neuwald, A.F.2
Ponting, C.P.3
-
22
-
-
21644438874
-
Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein
-
Bonneau F., D'Angelo I., Welti S., Stier G., Ylanne J., and Scheffzek K. Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein. Acta Crystallogr. D Biol. Crystallogr. 60 (2004) 2364-2367
-
(2004)
Acta Crystallogr. D Biol. Crystallogr.
, vol.60
, pp. 2364-2367
-
-
Bonneau, F.1
D'Angelo, I.2
Welti, S.3
Stier, G.4
Ylanne, J.5
Scheffzek, K.6
-
23
-
-
33645831773
-
A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein
-
D'Angelo I., Welti S., Bonneau F., and Scheffzek K. A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein. EMBO Rep. 7 (2006) 174-179
-
(2006)
EMBO Rep.
, vol.7
, pp. 174-179
-
-
D'Angelo, I.1
Welti, S.2
Bonneau, F.3
Scheffzek, K.4
-
24
-
-
33846396338
-
The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex
-
Welti S., Fraterman S., D'Angelo I., Wilm M., and Scheffzek K. The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex. J. Mol. Biol. 366 (2007) 551-562
-
(2007)
J. Mol. Biol.
, vol.366
, pp. 551-562
-
-
Welti, S.1
Fraterman, S.2
D'Angelo, I.3
Wilm, M.4
Scheffzek, K.5
-
25
-
-
0029897881
-
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase
-
Izawa I., Tamaki N., and Saya H. Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase. FEBS Lett. 382 (1996) 53-59
-
(1996)
FEBS Lett.
, vol.382
, pp. 53-59
-
-
Izawa, I.1
Tamaki, N.2
Saya, H.3
-
26
-
-
0033924917
-
Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain
-
Fahsold R., Hoffmeyer S., Mischung C., Gille C., Ehlers C., Kucukceylan N., Abdel-Nour M., Gewies A., Peters H., Kaufmann D., et al. Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain. Am. J. Hum. Genet. 66 (2000) 790-818
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 790-818
-
-
Fahsold, R.1
Hoffmeyer, S.2
Mischung, C.3
Gille, C.4
Ehlers, C.5
Kucukceylan, N.6
Abdel-Nour, M.7
Gewies, A.8
Peters, H.9
Kaufmann, D.10
-
27
-
-
0027310225
-
Characterization of full-length neurofibromin: tubulin inhibits Ras GAP activity
-
Bollag G., McCormick F., and Clark R. Characterization of full-length neurofibromin: tubulin inhibits Ras GAP activity. EMBO J. 12 (1993) 1923-1927
-
(1993)
EMBO J.
, vol.12
, pp. 1923-1927
-
-
Bollag, G.1
McCormick, F.2
Clark, R.3
-
28
-
-
33847624936
-
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit
-
Tarendeau F., Boudet J., Guilligay D., Mas P.J., Bougault C.M., Boulo S., Baudin F., Ruigrok R.W., Daigle N., Ellenberg J., et al. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat. Struct. Mol. Biol. 14 (2007) 229-233
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 229-233
-
-
Tarendeau, F.1
Boudet, J.2
Guilligay, D.3
Mas, P.J.4
Bougault, C.M.5
Boulo, S.6
Baudin, F.7
Ruigrok, R.W.8
Daigle, N.9
Ellenberg, J.10
-
29
-
-
50849137828
-
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit
-
Tarendeau F., Crepin T., Guilligay D., Ruigrok R.W., Cusack S., and Hart D.J. Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog. 4 (2008) e1000136
-
(2008)
PLoS Pathog.
, vol.4
-
-
Tarendeau, F.1
Crepin, T.2
Guilligay, D.3
Ruigrok, R.W.4
Cusack, S.5
Hart, D.J.6
-
30
-
-
43249128376
-
The structural basis for cap binding by influenza virus polymerase subunit PB2
-
Guilligay D., Tarendeau F., Resa-Infante P., Coloma R., Crepin T., Sehr P., Lewis J., Ruigrok R.W., Ortin J., Hart D.J., et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat. Struct. Mol. Biol. 15 (2008) 500-506
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 500-506
-
-
Guilligay, D.1
Tarendeau, F.2
Resa-Infante, P.3
Coloma, R.4
Crepin, T.5
Sehr, P.6
Lewis, J.7
Ruigrok, R.W.8
Ortin, J.9
Hart, D.J.10
-
33
-
-
32244437769
-
Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells
-
Mangoura D., Sun Y., Li C., Singh D., Gutmann D.H., Flores A., Ahmed M., and Vallianatos G. Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. Oncogene 25 (2006) 735-745
-
(2006)
Oncogene
, vol.25
, pp. 735-745
-
-
Mangoura, D.1
Sun, Y.2
Li, C.3
Singh, D.4
Gutmann, D.H.5
Flores, A.6
Ahmed, M.7
Vallianatos, G.8
-
34
-
-
0032479992
-
Structural analysis of the GAP-related domain from neurofibromin and its implications
-
Scheffzek K., Ahmadian M.R., Wiesmuller L., Kabsch W., Stege P., Schmitz F., and Wittinghofer A. Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J. 17 (1998) 4313-4327
-
(1998)
EMBO J.
, vol.17
, pp. 4313-4327
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wiesmuller, L.3
Kabsch, W.4
Stege, P.5
Schmitz, F.6
Wittinghofer, A.7
-
36
-
-
8744219635
-
Pleckstrin homology domains: not just for phosphoinositides
-
Lemmon M.A. Pleckstrin homology domains: not just for phosphoinositides. Biochem. Soc. Trans. 32 (2004) 707-711
-
(2004)
Biochem. Soc. Trans.
, vol.32
, pp. 707-711
-
-
Lemmon, M.A.1
-
37
-
-
0029392854
-
HEAT repeats in the Huntington's disease protein
-
Andrade M.A., and Bork P. HEAT repeats in the Huntington's disease protein. Nat. Genet. 11 (1995) 115-116
-
(1995)
Nat. Genet.
, vol.11
, pp. 115-116
-
-
Andrade, M.A.1
Bork, P.2
-
38
-
-
0035371069
-
Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans
-
Hsueh Y.P., Roberts A.M., Volta M., Sheng M., and Roberts R.G. Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans. J. Neurosci. 21 (2001) 3764-3770
-
(2001)
J. Neurosci.
, vol.21
, pp. 3764-3770
-
-
Hsueh, Y.P.1
Roberts, A.M.2
Volta, M.3
Sheng, M.4
Roberts, R.G.5
-
39
-
-
0037443055
-
Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
-
Cichowski K., Santiago S., Jardim M., Johnson B.W., and Jacks T. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 17 (2003) 449-454
-
(2003)
Genes Dev.
, vol.17
, pp. 449-454
-
-
Cichowski, K.1
Santiago, S.2
Jardim, M.3
Johnson, B.W.4
Jacks, T.5
|