Bipartite interaction between neurofibromatosis type I protein (Neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans

Journal of Neuroscience

Volumn 21, Issue 11, 2001, Pages 3764-3770

  Hsueh, Yi Ping ^a,b   Roberts, Anne M ^c   Volta, Manuela ^c   Sheng, Morgan ^b   Roberts, Roland G ^c  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Axon; CASK LIN 2; NF1; Postsynaptic density; RasGAP; Yeast two hybrid analysis

Indexed keywords

NEUROFIBROMIN; PROTEOHEPARAN SULFATE; SYNDECAN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; DRUG RECEPTOR BINDING; GENE DISRUPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE;

EID: 0035371069     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-11-03764.2001     Document Type: Article

References (15)

1. Asundi V, Carey D (1995) Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. J Biol Chem 270:26404-26410.
2. Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F (1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851-859.
3. Bernfield M, Kokenyesi R, Kato M, Hinkes MT, Spring J, Gallo RL, Lose EJ (1992) Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycans. Annu Rev Cell Biol 8:365-393.
4. Brannan C, Perkins A, Vogel K, Ratner N, Nordlund M, Reid S, Buchberg A, Jenkins N, Parada L, Copeland N (1994) Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 8:1019-1029.
5. Bredt DS (1998) Sorting out genes that regulate epithelial and neuronal polarity. Cell 94:691-694.
6. Butz S, Okamoto M, Südhof TC (1998) A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94:773-782.
7. Carey D (1997) Syndecans: multifunctional cell-surface coreceptors. Biochem J 327:1-16.
8. Cichowski K, Shih T, Schmitt E, Santiago S, Reilly K, McLaughlin M, Bronson R, Jacks T (1999) Mouse models of tumor development in neurofibromatosis type 1. Science 286:2172-2176.
9. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM (1998) Human Cask/Lin-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol 142:129-138.
10. Daston M, Scrable H, Nordlund M, Sturbaum A, Nissen L, Ratner N (1992) The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron 8:415-428.
11. David G (1993) Integral membrane heparan sulfate proteoglycans. FASEB J 7:1023-1030.
12. Ethell I, Yamaguchi Y (1999) Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J Cell Biol 144:575-586.
13. Grootjans J, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, David G (1997) Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci USA 94:13683-13688.
14. Guo H, The I, Hannan F, Bernards A, Zhong Y (1997) Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science 276:795-798.
15. Guo H, Tong J, Hannan F, Luo L, Zhong Y (2000) A neurofibro-matosis-1-regulated pathway is required for learning in Drosophila. Nature 403:895-898.