Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors

Bioscience Reports

Volumn 28, Issue 6, 2008, Pages 299-306

  Seredenina, Tamara ^a   Ferraro, Teresa ^a   Terstappen, Georg C ^a   Caricasole, Andrea ^a   Roncarati, Renza ^a  

^a Siena Biotech SpA   (Italy)

Author keywords

bungarotoxin (a Bgt); 7 nicotinic acetylcholine receptor ( 7 nAChR); Chaperone; Resistant to inhibitors of cholinesterase 3 (RIC 3); Splice variant

Indexed keywords

ALPHA-BUNGAROTOXIN RECEPTOR; BUNGAROTOXIN RECEPTOR; CHAPERONE; ISOPROTEIN; MESSENGER RNA; NICOTINIC RECEPTOR; RIC3 PROTEIN, HUMAN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; CHO CELL; CRICETULUS; EXON; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; EXONS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; RNA, MESSENGER;

EID: 60249103122     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20080055     Document Type: Article

References (28)

1. Dajas-Bailador, F. and Wonnacott, S. (2004) Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol. Sci. 25, 317-324
2. Gotti, C., Riganti, L., Vailati, S. and Clementi, F. (2006) Brain neuronal nicotinic receptors as new targets for drug discovery. Curr. Pharm. Des. 12, 407-428
3. Levin, E. D. and Rezvani, A. H. (2002) Nicotinic treatment for cognitive dysfunction. Curr. Drug Targets. CNS. Neurol. Disord. 1, 423-431
4. Rusted, J. M., Newhouse, P. A. and Levin, E. D. (2000) Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease. Behav. Brain Res. 113, 121-129
5. Martin, L. F., Kem, W. R. and Freedman, R. (2004) α-7 Nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology 174, 54-64
6. Cooper, S. T. and Millar, N. S. (1997) Host cell-specific folding and assembly of the neuronal nicotinic acetylcholine receptor α7 subunit. J. Neurochem. 68, 2140-2151
7. Quik, M., Choremis, J., Komourian, J., Lukas, R. J. and Puchacz, E. (1996) Similarity between rat brain nicotinic α-bungarotoxin receptors and stably expressed α-bungarotoxin binding sites. J. Neurochem. 67, 145-154
8. Rangwala, F., Drisdel, R. C., Rakhilin, S., Ko, E., Atluri, P., Harkins, A. B., Fox, A. P., Salman, S. S. and Green, W. N. (1997) Neuronal α-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors. J. Neurosci. 17, 8201-8212
9. Sweileh, W., Wenberg, K., Xu, J., Forsayeth, J., Hardy, S. and Loring, R. H. (2000) Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptorsubtype- dependent. Brain Res. Mol. Brain Res. 75, 293-302
10. Chen, D., Dang, H. and Patrick, J. W. (1998) Contributions of N-linked glycosylation to the expression of a functional α7-nicotinic receptor in Xenopus oocytes. J. Neurochem. 70, 349-357
11. Blumenthal, E. M., Conroy, W. G., Romano, S. J., Kassner, P. D. and Berg, D. K. (1997) Detection of functional nicotinic receptors blocked by α-bungarotoxin on PC12 cells and dependence of their expression on post-translational events. J. Neurosci. 17, 6094-6104
12. Halevi, S., McKay, J., Palfreyman, M., Yassin, L., Eshel, M., Jorgensen, E. and Treinin, M. (2002) The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors. EMBO J. 21, 1012-1020
13. Williams, M. E., Burton, B., Urrutia, A., Shcherbatko, A., Chavez-Noriega, L. E., Cohen, C. J. and Aiyar, J. (2005) Ric-3 promotes functional expression of the nicotinic acetylcholine receptor α7 subunit in mammalian cells. J. Biol. Chem. 280, 1257-1263
14. Halevi, S., Yassin, L., Eshel, M., Sala, F., Sala, S., Criado, M. and Treinin, M. (2003) Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. J. Biol. Chem. 278, 34411-34417
15. Cheng, A., Bollan, K. A., Greenwood, S. M., Irving, A. J. and Connolly, C. N. (2007) Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition. J. Biol. Chem. 282, 26158-26166
16. Castelan, F., Castillo, M., Mulet, J., Sala, S., Sala, F., Dominguez del Toro, E. and Criado, M. (2008) Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. J Neurochem. 105, 617-627
17. Castillo, M., Mulet, J., Gutierrez, L. M., Ortiz, J. A., Castelan, F., Gerber, S., Sala, S., Sala, F. and Criado, M. (2005) Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. J. Biol. Chem. 280, 27062-27068
18. Lansdell, S. J., Gee, V. J., Harkness, P. C., Doward, A. I., Baker, E. R., Gibb, A. J. and Millar, N. S. (2005) RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. Mol. Pharmacol. 68, 1431-1438
19. Edgar, R. C. (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792-1797
20. Roncarati, R., Seredenina, T., Jow, B., Jow, F., Papini, S., Kramer, A., Bothmann, H., Dunlop, J. and Terstappen, G. C. (2008) Functional properties of α7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. Assay Drug Dev. Technol. 6, 181-193
21. Seguela, P., Wadiche, J., Dineley-Miller, K., Dani, J. A. and Patrick, J. W. (1993) Molecular cloning, functional properties, and distribution of rat brain α 7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13, 596-604
22. Dominguez del Toro, E., Juiz, J. M., Peng, X., Lindstrom, J. and Criado, M. (1994) Immunocytochemical localization of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. J. Comp. Neurol. 349, 325-342
23. Bray, C., Son, J. H., Kumar, P. and Meizel, S. (2005) Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility. Biol. Reprod. 73, 807-814
24. Kumar, P. and Meizel, S. (2005) Nicotinic acetylcholine receptor subunits and associated proteins in human sperm. J. Biol. Chem. 280, 25928-25935
25. Hurst, R. S., Hajos, M., Raggenbass, M., Wall, T. M., Higdon, N. R., Lawson, J. A., Rutherford-Root, K. L., Berkenpas, M. B., Hoffmann, W. E., Piotrowski, D. W. et al. (2005) A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J. Neurosci. 25, 4396-4405
26. Ben Ami, H. C., Yassin, L., Farah, H., Michaeli, A., Eshel, M. and Treinin, M. (2005) RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. J. Biol. Chem. 280, 28053-28060
27. Lansdell, S. J., Collins, T., Yabe, A., Gee, V. J., Gibb, A. J. and Millar, N. S. (2008) Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. J. Neurochem. 105, 1573-1581
28. Rose, A. and Meier, I. (2004) Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins. Cell. Mol. Life Sci. 61, 1996-2009