The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: A molecular modelling study

Molecular and Cellular Endocrinology

Volumn 301, Issue 1-2, 2009, Pages 235-244

  Karkola, Sampo ^a   Wähälä, Kristiina ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Aromatase; CYP450; Enterolactone; Flavone; Isoflavone; Lignan; Molecular modelling; Phytoestrogen

Indexed keywords

3 DEMETHOXY 3' O DEMETHYLMATAIRESINOL; 3 DEMETHOXYMATAIRESINOL; 3' DEMETHOXYSECOISOLARICIRESINOL; 3' DEMETHYLSECOISOLARICIRESINOL; 3,3,' DIDEMTHYLSECOISOLARICIRESINOL; 4,4' DIHYDROXYENTEROLACTONE; ALPHA NAPHTHOFLAVONE; APIGENIN; AROMATASE; BIOCHANIN A; CHRYSIN; COUMESTROL; CYTOCHROME P450; DIDEMETHOXYMATAIRESINOL; ENTERODIOL; ENTEROLACTONE; FLAVONOID; GALANGIN; GENISTEIN; ISOFLAVONE; LIGNAN DERIVATIVE; MATAIRESINOL; NORDIHYDROGUAIARETIC ACID; PHYTOESTROGEN; QUERCETIN; SECOISOLARICIRESINOL; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL;

4-BUTYROLACTONE; ANDROGENS; AROMATASE; BENZOFLAVONES; CATALYTIC DOMAIN; COMPUTER SIMULATION; COUMESTROL; ESTRONE; HEME; LIGNANS; MODELS, MOLECULAR; PHYTOESTROGENS;

EID: 60249092439     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.10.003     Document Type: Article

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