Lead optimization of 7-benzyloxy 2-(4′-pyridylmethyl)thio isoflavone aromatase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6571-6577

  Su, Bin ^a   Hackett, John C ^a   Díaz Cruz, Edgar S ^a   Kim, Young Woo ^a   Brueggemeier, Robert W ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

interaction; Aromatase; Enzyme inhibitors; Isoflavones; SK BR 3 breast cancer cells

Indexed keywords

3 PHENYL 7 (2' METHOXYPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (2' NITROPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (2' PYRIDYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (3' NITROPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' BIPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' BROMOPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' CHLOROPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' FLUOROPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' METHOXYPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (4' NITROPHENYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (ALPHA NAPHTHYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (BETA NAPHTHYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (CYCLOHEXYLMETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; 3 PHENYL 7 (PHENYLETHOXY) 2 [(4' PYRIDYLMETHYL)THIO] 4H 1 BENZOPYRAN 4 ONE; ANDROSTENEDIONE; AROMATASE INHIBITOR; ISOFLAVONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50;

AROMATASE; AROMATASE INHIBITORS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; ISOFLAVONES; KINETICS; MICROSOMES; MOLECULAR STRUCTURE; PLACENTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27544469200     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.038     Document Type: Article

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