In vivo mouse model for analysis of hydroxysteroid (17β) dehydrogenase 1 inhibitors

Molecular and Cellular Endocrinology

Volumn 301, Issue 1-2, 2009, Pages 158-162

  Lamminen, Tarja ^a   Saloniemi, Taija ^a   Huhtinen, Kaisa ^a   Koskimies, Pasi ^b   Messinger, Josef ^c   Husen, Bettina ^c   Thole, Hubert ^c   Poutanen, Matti ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b Hormos Medical Ltd   (Finland)

^c Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

Hydroxysteroid (17 ) dehydrogenase; Inhibitor; Transgenic mouse

Indexed keywords

17 BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; ESTRONE; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENE;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PROMOTER REGIONS, GENETIC; TRANSGENES;

EID: 60249089420     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.10.034     Document Type: Article

References (45)

1. Adamski J., and Jakob F.J. A guide to 17β-hydroxysteroid dehydrogenases. Mol. Cell. Endocrinol. 171 (2001) 1-4
2. Aghajanova, L., Hamilton, A., Kwintkiewicz, J., Vo, K.C., Giudice, L.C., Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biol. Reprod. in press.
3. Akinola L.A., Poutanen M., and Vihko R. Cloning of rat 17β- hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Endocrinology 137 (1996) 1572-1579
4. Baker M.E. Evolution of 17β-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. Mol. Cell. Endocrinol. 171 (2001) 211-215
5. Bonney R.C., Reed M.J., Davidson K., Beranek P.A., and James V.H. The relationship between 17β-hydroxysteroid dehydrogenase activity and oestrogen concentrations in human breast tumors and in normal breast tissue. Clin. Endocrinol. 19 (1983) 727-739
6. Carneiro M.M., Morsch D.M., Camargos A.F., Spritzer P.M., and Reis F.M. Expression of 17beta-hydroxysteroid dehydrogenase type 2 in pelvic endometriosis. Gynecol. Endocrinol. 23 (2007) 188-192
7. Casey M.L., MacDonald P.C., and Andersson S. 17β-hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J. Clin. Invest. 94 (1994) 2135-2141
8. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
9. Dassen H., Punyadeera C., Kamps R., Delvoux B., Van Langendonckt A., Donnez J., Husen B., Thole H., Dunselman G., and Groothuis P. Estrogen metabolizing enzymes in endometrium and endometriosis. Hum. Reprod. 22 (2007) 3148-3158
10. Fournet-Dulguerov N., MacLusky N.J., Leranth C.Z., Todd R., Mendelson C.R., Simpson E.R., and Naftolin F. Immunohistocehmical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. J. Clin. Endocrinol. Metab. 65 (1987) 757-764
11. Geisler J., and Lønning P.E. Aromatase inhibition: translation into a successful therapeutic approach. Clin. Cancer Res. 11 (2005) 2809-2821
12. Ghersevich S.A., Poutanen M., Martikainen H.K., and Vihko R.K. Expression of 17 beta-hydroxysteroid dehydrogenase in human granulose cells: correlation with follicular size, cytochrome P450 aromatase activity and oestradiol production. J. Endocrinol. 143 (1994) 139-150
13. Goss P.E., and Strasser K. Chemoprevention with aromatase inhibitors - trial strategies. J. Steroid Biochem. Mol. Biol. 79 (2001) 143-149
14. Gunnarsson C., Jerevall P.L., Hammar K., Olsson B., Nordenskjöld B., Jansson A., and Stål O. Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer. Breast Cancer Res. Treat. 108 (2008) 35-41
15. Hogan B.L., Constantini E., and Lacy E. Manipulating the Mouse Embryo (1986), Cold Spring Harbor Press, New York
16. Husen B., Huhtinen K., Poutanen M., Kangas L., Messinger J., and Thole H. Evaluation of inhibitors for 17β-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme. Mol. Cell. Endocrinol. 27 (2006) 109-113
17. Husen B., Huhtinen K., Saloniemi T., Messinger J., Thole H.H., and Poutanen M. Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts. Endocrinology 147 (2006) 5333-5339
18. Labrie F., Luu-The V., Lin S.X., Simard J., Labrie C., El-Alfy M., Pelletier G., and Bélanger A. Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease. J. Mol. Endocrinol. 25 (2000) 1-16
19. Matsuzaki S., Canis M., Pouly J.L., Déchelotte P.J., and Mage G. Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection. Fertil. Steril. 85 (2006) 308-313
20. McNeill J.M., Reed M.J., Beranek P.A., Bonney R.C., Ghilchik M.W., Robinson D.J., and James V.H. A comparison of the in vivo uptake and metabolism of 3H-oestrone and 3H-oestradiol by normal breast and breast tumour tissues in post-menopausal women. Int. J. Cancer 38 (1986) 193-196
21. Miettinen M.M., Mustonen M.V.J., Poutanen M.H., Isomaa V.V., and Vihko R.K. Human 17β-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultures cells and characteristic cell- and tissue-specific expression. Biochem. J. 314 (1996) 839-845
22. Miettinen M., Mustonen M., Poutanen M., Isomaa V., Wickman M., Söderqvist G., Vihko R., and Vihko P. 17β-hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue. Breast Cancer Res. Treat. 57 (1999) 175-182
23. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1988) 1215
24. Mindnich R., Möller G., and Adamski J. The role of 17β-hydroxysteroid dehydrogenases. Mol. Cell. Endocrinol. 218 (2004) 7-20
25. Noble L.S., Simpson E.R., Johns A., and Bulun S.E. Aromatase expression in endometriosis. J. Clin. Endocrinol. Metab. 81 (1996) 174-179
26. Oduwole O.O., Li Y., Isomaa V.V., Mäntyniemi A., Pulkka A.E., Soini Y., and Vihko P.T. 17β-hydroxysteroid dehydrogenase type 1 is an independent prognostic marker in breast cancer. Cancer Res. 64 (2004) 7604-7609
27. Peltoketo H., Luu-The V., Simard L., and Adamski J. 17β-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nolenclature and main characteristics of the 17HSD/KSR enzymes. J. Mol. Endocrinol. 23 (1999) 1-11
28. Poutanen M., Isomaa V., Lehto V.-P., and Vihko R. Immunological analysis of 17β-hydroxysteroid dehydrogenase in benign and malignant human breast tissue. Int. J. Cancer 50 (1992) 386-390
29. Poutanen M., Miettinen M., and Vihko R. Differential estrogen substrate specificities for transiently expressed human placental 17β-hydroxysteroid dehydrogenase and endogenous enzyme expressed in cultured COS-m6 cells. Endocrinology 133 (1993) 2639-2644
30. Poutanen M., Isomaa V., Peltoketo H., and Vihko R. Role of 17β-hydroxysteroid dehydrogenase type I in endocrine and intracrine estradiol biosynthesis. J. Steroid. Biochem. 55 (1995) 525-532
31. Puranen T., Poutanen M., Ghosh D., Vihko P., and Vihko R. Characterization of structural and functional properties of human 17β-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis. Mol. Endo. 11 (1997) 77-86
32. Puranen T., Poutanen M., Ghosh D., Vihko P., and Vihko R. Origin of substrate specificity of human and rat 17β-hydroxysteroid dehydrogenase type 1, using chimeric enzymes and site-directed substitutions. Endocrinol. 138 (1997) 3532-3539
33. Rugo H.S. The breast cancer continuum in hormone-receptor-positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors. Ann. Oncol. 19 (2008) 16-27
34. Saloniemi T., Lamminen T., Huhtinen K., Welsh M., Saunders P., Kujari H., and Poutanen M. Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas. Mol. Endocrinol. 21 (2007) 2627-2636
35. Satyaswaroop P.G., Wartell D.J., and Mortel R. Distribution of progesterone receptor, estradiol dehydrogenase, and 20 alpha-dihydroprogesterone dehydrogenase activities in human endometrial glands and stroma: progestin induction of steroid dehydrogenase activities in vitro is restricted to the glandular epithelium. Endocrinology 111 (1982) 743-749
36. Smuc T., Pucelj M.R., Sinkovec J., Husen B., Thole H., and Lanisnik Rizner T. Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis. Gynecol. Endocrinol. 23 (2007) 105-111
37. Smuc, T., Hevir, N., Ribič-Pucelj, M., Husen, B., Thole, H., Rižner, T.L., Disturbed estrogen and progesterone action in ovarian endometriosis. Mol. Cell. Endocrinol. in press.
38. Tseng L., and Gurpide E. Induction of human endometrial estradiol dehydrogenase by progestins. Endocrinology 97 (1975) 825-833
39. Tseng L., and Gurpide E. Stimulation of various 17β- and 20α-hydroxysteroid dehydrogenase activities by progestins in human endometrium. Endocrinology 104 (1979) 1745-1748
40. Vermeulen A., Deslypere J.P., and Paridaens R. Steroid dynamics in the normal and carcinomatous mammary gland. J. Steroid Biochem. 25 (1986) 799-802
41. Yue W., Wang J.P., Hamilton C.J., Demers L.M., and Santen R.J. In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res. 58 (1998) 927-932
42. Yue W., Wang J.P., Li Y., Bocchinfuso W.P., Korach K.S., Devanesan P.D., Rogan E., Cavalieri E., and Santen R.J. Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin. Cancer Res. 11 (2005) 925s-930s
43. Zeitoun K., Takayama K., Sasano H., Suzuki T., Moghrabi N., Andersson S., Johns A., Meng L., Putman M., Carr B., and Bulun S.E. Deficient 17β-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17β-estradiol. J. Clin. Endocrinol. 83 (1998) 4474-4480
44. Zhongyi S., Rantakari P., Lamminen T., Toppari J., and Poutanen M. Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids. Endocrinology 148 (2007) 3827-3836
45. Wu L., Einstein M., Geissler W.M., Chan H.K., Elliston K.O., and Andersson S. Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J. Biol. Chem. 17 (1993) 12964-12969