Cloning of rat 17β-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes

Endocrinology

Volumn 137, Issue 5, 1996, Pages 1572-1579

  Akinola, Lateef A ^a,b   Poutanen, Matti ^a   Vihko, Reijo ^a  

^a UNIVERSITY OF OULU   (Finland)

^b WHO Spec Prog Res Devmt

Author keywords

[No Author keywords available]

Indexed keywords

17 OXOSTEROID; ANDROGEN; ANDROSTENEDIONE; COMPLEMENTARY DNA; ESTROGEN; ESTRONE; ISOENZYME; MESSENGER RNA; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CATALYSIS; DNA SEQUENCE; EMBRYO; ENZYME ACTIVITY; ENZYME STRUCTURE; ESTROGEN METABOLISM; FEMALE; HUMAN; HUMAN CELL; KIDNEY; LIVER; MALE; NONHUMAN; OXIDATION; PLACENTA; PRIORITY JOURNAL; RAT; REDUCTION; SMALL INTESTINE; TISSUE DISTRIBUTION;

EID: 0029913731     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.5.8612487     Document Type: Article

References (42)

1. Martel C, Rheaume E, Takahashi M, Trudel C, Couët J, Luu-The V, Simard J, Labrie F 1992 Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues. J Steroid Biochem Mol Biol 41:597-603
2. Peltoketo H, Isomaa V, Mäentausta O, Vihko R 1988 Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett 239:73-77
3. Luu The V, Labrie C, Zhao HF, Couët J, Lachance Y, Simard J, Leblanc G, Côté J, Bérubé D, Gagné R, Labrie F 1989 Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Mol Endocrinol 3:1301-1309
4. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J Biol Chem 268:12964-12969
5. Geissler WM, Davis DL, Wu L, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW, Andersson S 1994 Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3. Nature Genet 7:34-39
6. Leenders F, Adamski J, Husen B, Thole HH, Jungblut PW 1994 Molecular cloning and amino acid sequence of the porcine 17β-estradiol dehydrogenase. Eur J Biochem 222:221-227
7. Deyashiki Y, Ohshima K, Nakanishi M, Sato K, Matsuura K, Hara A 1995 Molecular cloning and characterization of mouse estradiol 17β-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem 270:10461-10467
8. Puranen T, Poutanen M, Peltoketo H, Vihko P, Vihko R 1994 Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1. Biochem J 304:289-293
9. Poutanen M, Miettinen M, Vihko R 1993 Differential estrogen substrate specificities for transiently expressed human placental 17β-hydroxysteroid dehydrogenase and an endogenous enzyme expressed in cultured COS-m6 cells. Endocrinology 133:2639-2644
10. Miettinen MM, Mustonen MVJ, Poutanen MH, Isomaa VV, Vihko RK, Human 17β-hydroxysteroid dehydrogenase type 1, type 2 isoenzymes have opposite activities in cultured cells and characteristic cell and tissue specific expression. Biochem J, in press
11. Poutanen M, Isomaa V, Peltoketo H, Vihko R 1945 Role of 17β-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis. J Steroid Biochem Mol Biol 55:525-532
12. Casey LM, MacDonald PC, Andersson S 1994 17β-hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J Clin Invest 94:2135-2141
13. Poutanen M, Isomaa V, Peltoketo H, Vihko R 1995 Regulation of estrogen action: role of 17β-hydroxysteroid dehydrogenases. Ann Med 27:675-682
14. Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F 1995 The human type II 17β-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. DNA Cell Biol 14:849-861
15. Tremblay Y, Ringler GE, Morel Y, Mohandas TK, Labrie F, Strauss III JF, Miller WL 1989 Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen→q25. J Biol Chem 264:20458-20462
16. Jantus-Lewintre E, Orava M, Peltoketo H, Vihko R 1994 Characterization of 17β-hydroxysteroid dehydrogenase type 1 in choriocarcinoma cells: regulation by basic fibroblast growth factor. Mol Cell Endocrinol 104:1-9
17. Ghersevich SA, Poutanen MH, Martikainen HK, Vihko RK 1994 Expression of 17β-hydroxysteroid dehydrogenase in human granulosa cells: correlation with follicular size, cytochrome P-450 aromatase activity and oestradiol production. J Endocrinol 143:139-150
18. Ghersevich S, Nokelainen P, Poutanen M, Orava M, Autio-Harmainen H, Rajaniemi H, Vihko R 1994 Rat 17β-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Endocrinology 135:1477-1487
19. Ghersevich S, Poutanen M, Rajaniemi H, Vihko R 1994 Expression of 17β-hydroxysteroid dehydrogenase in the rat ovary during follicular development and luteinization induced with pregnant mare serum gonadotrophin and human chorionic gonadotrophin. J Endocrinol 140:409-417
20. Sawetawan C, Milewich L, Word RA, Carr BR, Rainey WE 1994 Compartmentalization of type I 17β-hydroxysteroid oxidoreductase in the human ovary. Mol Cell Endocrinol 99:161-168
21. Mäentausta O, Peltoketo H, Isomaa V, Jouppila P, Vihko R 1990 Immunological measurement of human 17β-hydroxysteroid dehydrogenase. J Steroid Biochem 36:673-680
22. Mäentausta O, Sormunen R, Isomaa V, Lehto V-P, Jouppila P, Vihko R 1991 Immunohistochemical localization of 17β-hydroxysteroid dehydrogenase in the human endometrium during the menstrual cycle. Lab Invest 65:582-587
23. Devereux J, Haeberli P, Smithies O 1984 A comprehensive set of sequence analysis programme for the VAX. Nucleic Acids Res 12: 387-395
24. Bairoch A 1993 The prosite dictionary of sites and patterns in proteins. Nucleic Acids Res 21:3097-3103
25. von Heijne G, Manoil C 1990 Membrane proteins: from sequence to structure. Protein Engin 4:109-112
26. Haltia T, Freire E 1995 Forces and factors that contribute to the structural stability of membrane proteins. Biochim Biophys Acta 1228:1-27
27. Jackson MR, Nilsson T, Peterson PA 1990 Identification of a consensus motif for retention of transmemberane proteins in the endoplasmic reticulum. EMBO J 9:3153-3162
28. Nilsson T, Warren G 1994 Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus. Curr Opin Cell Biol 6:517-521
29. Krozowski Z 1994 The short-chain alcohol dehydrogenase superfamily: variations on a common theme. J Steroid Biochem Mol Biol 51:125-130
30. Baker ME 1994 Sequence analysis of steroid- and prostaglandin-metabolizing enzymes: application to understanding catalysis. Steroids 59:248-258
31. Jörnvall H, Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D 1995 Short-chain dehydrogenases/reductases (SDR). Biochemistry 34:6003-6013
32. Ghosh D, Wawrzak Z, Weeks CM, Duax WL, Erman M 1994 The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases. Structure 2:629-640
33. Ghosh D, Pletnev VZ, Zhu D-W, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin S-X 1995 Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 Å resolution. Structure 3:503-513
34. Chen Z, Jiang JC, Lin Z-G, Lee WR, Baker ME, Chang SH 1993 Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Biochemistry 32:3342-3346
35. Poutanen M, Moncharmont B, Vihko R 1992 17β-Hydroxysteroid dehydrogenase gene expression in human breast cancer cells: regulation of expression by a progestin. Cancer Res 52:290-294
36. Tremblay Y, Beaudoin C 1993 Regulation of 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase messenger ribonucleic acid levels by cyclic adenosine 3′,5′-monophosphate and phorbol myristate acetate in human choriocarcinoma cells. Mol Endocrinol 7:355-364
37. Reed MJ, Rea D, Duncan LJ, Parker MG 1994 Regulation of estradiol 17β-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells. Endocrinology 135:4-9
38. Warshaw ML, Johnson DC, Khan I, Eckstein B, Gibori G 1986 Placental secretion of androgens in the rat. Endocrinology 119:2642-2648
39. Jackson JA, Albrecht ED 1985 The development of placental androstenedione and testosterone production and their utilization by the ovary for aromatization to estrogen during rat pregnancy. Biol Reprod 33:451-457
40. SCC gene expression and regulation in the rat placenta. Endocrinology 130:1309-1317
41. Elo JP, Akinola LA, Poutanen M, Vihko P, Kyllönen AP, Lukkarinen O, Vihko R, Characterization of 17β-hydroxysteroid dehydrogenase isoenzyme expression in benign, malignant human prostate. Int J Cancer, in press
42. Kyte J, Doolittle RF 1982 A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105-132