Origin of substrate specificity of human and rat 17β-hydroxysteroid dehydrogenase type 1, using chimeric enzymes and site-directed substitutions

Endocrinology

Volumn 138, Issue 8, 1997, Pages 3532-3539

  Puranen, Terhi ^a   Poutanen, Matti ^a   Ghosh, Debashis ^b,c   Vihko, Reijo ^a   Vihko, Pirkko ^a  

^a UNIVERSITY OF OULU   (Finland)

^b HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTRONE; TESTOSTERONE 17BETA DEHYDROGENASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHIMERA; ENZYME SPECIFICITY; ESTRADIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SITE DIRECTED MUTAGENESIS; STEROID ANALYSIS; STRUCTURE ANALYSIS;

EID: 0030786399     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.8.5303     Document Type: Article

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