Design, synthesis and structure-activity relationships of antiproliferative 1,3-disubstituted urea derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 453-459

  Li, Huan Qiu ^a   Zhu, Tao Tao ^a   Yan, Tao ^a   Luo, Yin ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antiproliferative; K562 cell line; KB cell line; Morpholine ring; SAR; Urea derivatives

Indexed keywords

1 (2 HYDROXY 5 NITROBENZYL) 3,3 DIMETHYL 1 (2 MORPHOLINOETHYL)UREA; 1 (2 HYDROXY 5 NITROBENZYL) 3,3 DIMETHYL 1 (3 MORPHOLINOPROPYL)UREA; 1 (4 HYDROXYBENZYL) 3,3 DIMETHYL 1 (2 MORPHOLINOETHYL)UREA; 1 (4 HYDROXYBENZYL) 3,3 DIMETHYL 1 (3 MORPHOLINOPROPYL)UREA; 1 (5 BROMO 2 HYDROXYBENZYL) 1 (FURAN 2 YLMETHYL) 3,3 DIMETHYLUREA; 1 (5 BROMO 2 HYDROXYBENZYL) 3,3 DIMETHYL 1 (2 MORPHOLINOETHYL)UREA; 1 (5 BROMO 2 HYDROXYBENZYL) 3,3 DIMETHYL 1 (3 MORPHOLINOPROPYL)UREA; 1 (5 CHLORO 2 HYDROXYBENZYL) 1 (FURAN 2 YLMETHYL) 3,3 DIMETHYLUREA; 1 (5 CHLORO 2 HYDROXYBENZYL) 3,3 DIMETHYL 1 (2 MORPHOLINOETHYL)UREA; 1 (5 CHLORO 2 HYDROXYBENZYL) 3,3 DIMETHYL 1 (3 MORPHOLINOETHYL)UREA; 1 (FURAN 2 YLMETHYL) 1 (2 HYRDROXY 5 NITROBENZYL) 3,3 DIMETHYLUREA; 1 (FURAN 2 YLMETHYL) 1 (4 HYDROXYBENZYL) 3,3 DIMETHYLUREA; 1 (FURAN 2 YLMETHYL) 3,3 DIMETHYL 1 (3 NITROBENZYL)UREA; 1 (FURAN 2 YLMETHYL) 3,3 DIMETHYL 1 (4 NITROBENZYL)UREA; 1,1 DIMETHYL 3 (2 MORPHOLINOETHYL) 3 (3 NITROBENZYL)UREA; 1,1 DIMETHYL 3 (2 MORPHOLINOETHYL) 3 (4 NITROBENZYL)UREA; 1,1 DIMETHYL 3 (3 MORPHOLINOPROPYL) 3 (3 NITROBENZYL)UREA; 1,1 DIMETHYL 3 (3 MORPHOLINOPROPYL) 3 (4 NITROBENZYL)UREA; ETHYL 4 [1 (2 HYDROXY 5 NITROBENZYL) 3,3 DIMETHYLUREIDO]PIPERIDINE 1 CARBOXYLATE; ETHYL 4 [1 (4 HYDROXYBENZYL) 3,3 DIMETHYLUREIDO]PIPERIDINE 1 CARBOXYLATE; ETHYL 4 [1 (5 BROMO 2 HYDROXYBENZYL) 3,3 DIMETHYLUREIDO]PIPERIDINE 1 CARBOXYLATE; ETHYL 4 [1 (5 CHLORO 2 HYDROXYBENZYL) 3 DIMETHYLUREIDO]PIPERIDINE 1 CARBOXYLATE; ETHYL 4 [3,3 DIMETHYL 1 (3 NITROBENZYL)UREIDO]PIPERIDINE 1 CARBOXYLATE; ETHYL 4 [3,3 DIMETHYL 1 (4 NITROBENZYL)UREIDO]PIPERIDINE 1 CARBOXYLATE; ETOPOSIDE; HYDROXYL GROUP; PHENYL GROUP; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 60149112782     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.04.011     Document Type: Article

References (13)

1. Gourley M., and Williamson J.S. Curr. Pharm. Des. 6 (2000) 417-439
2. Ullrich A., and Schlessinger J. Cell 61 (1990) 203-212
3. Hubbard S.R., and Till J.H. Annu. Rev. Biochem. 69 (2000) 373-398
4. Hayman M.J., and Enrietto P.J. Cancer Cells 3 (1991) 302-307
5. Dikic I., and Giordano S. Curr. Opin. Cell Biol. 15 (2003) 128-135
6. Uckun F.M., and Mao C. Curr. Pharm. Des. 10 (2004) 1083-1091
7. Traxler P., Green J., Mett H., Sequin U., and Furet P. J. Med. Chem. 42 (1999) 1018-1026
8. Shimshoni J.A., Bialer M., Wlodarczyk B., Finnell R.H., and Yagen B. J. Med. Chem. 50 (2007) 6419-6427
9. Fortin J.S., Lacroix J., Desjardins M., Michel P., Alexandre P.E., and Rene C.G. Bioorg. Med. Chem. 15 (2007) 4456-4469
10. Watson R.J., Allen D.R., Birch H.L., Chapman G.A., Gayle A., Frances F.C., Knight L.A., Meier D., Oliver K., Meissner J.W.G., Owen D.A., Thomas E.J., Tremayne N., and Williams S.C. Bioorg. Med. Chem. Lett. 18 (2008) 147-151
11. Be′chard P., Lacroix J., and Poyet P. Eur. J. Med. Chem. 29 (1994) 963-966
12. Cao P., Huang X.F., Hui D., Ge H.M., Li H.Q., Ruan B.F., and Zhu H.L. Chem. Biodiv. 4 (2007) 881-886
13. Krzysztof P., P.JoannaPiotr K., Jan R., Wiesław P., Oliwia Z.S., Jerzy B., Janusz S.S., Aleksander P.M., and Grzegorz G. Cancer Lett. 203 (2004) 59-65