Effect of enalapril on the expression of TGF-β1, p-Smad2/3 and Smad7 in renal interstitial fibrosis in rats

Journal of Central South University (Medical Sciences)

Volumn 34, Issue 1, 2009, Pages 27-34

  Ning, Wangbin ^a   Tao, Lijian ^a   Liu, Chunyan ^a   Sun, Jian ^a   Xiao, Yun ^a   Hu, Jing ^a   Chen, Jiying ^a   Zheng, Xuan ^a   Wang, Wei ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Enalapril; Renal interstitial fibrosis; Smad; Transforming growth factor 1

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; MADH2 PROTEIN, RAT; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; SMAD7 PROTEIN, RAT; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; ARTICLE; FEMALE; FIBROSIS; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT; URETHRA OBSTRUCTION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ENALAPRIL; FEMALE; FIBROSIS; KIDNEY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; URETHRAL OBSTRUCTION;

EID: 60149104546     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Schiffer M, von Gersdorff G, Bitzer M. Smad proteins and transforming growth factor-beta signaling [J]. Kidney Int, 2000, 77 (Suppl 1): S45-52.
2. Hou F F, Zhang X, Zhang G H, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency [J]. N Engl J Med, 2006, 354(2):131-140.
3. Radford M G Jr, Donadio J V Jr, Bergstralh E J, et al. Predicting renal outcome in IgA nephropathy [J]. J Am Soc Nephrol, 1997, 8(2):199-207.
4. Riera M, Torras J, Cruzado J M, et al. The enhancement of endogenous cAMP with pituitary adenylate cyclase-activating polypeptide protects rat kidney against ischemia through the modulation of inflammatory response [J]. Transplantation, 2001, 72 (7):1217-1723.
5. XIN Jing, GU Yong, CHEN Jing, et al. Renoprotective effect of endothelin receptor antagonist bosentan and its possible mechanism [J]. Chinese Journal of Nephrology, 2002, 18(2):107-110.
6. Ruiz-Ortega M, Rupérez M, Esteban V, et al. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases [J]. Nephrol Dial Transplant, 2006, 21 (1):16-20.
7. Schiffer M, von Gersdorff G, Bitzer M, et al. Smad proteins and transforming growth factor-beta signaling [J]. Kidney Int, 2000, 77 (Suppl 1):S45-52.
8. Derynck R, Zhang Y E. Smad-dependent and Smad-independent pathways in TGF-beta family signaling [J]. Nature, 2003, 425(6958):577-584.
9. Koo J W, Kim Y, Rozen S, et al. Enalapril accelerates remodeling of the renal interstitium after release of unilateral ureteral obstruction in rats [J]. J Nephrol, 2003 (16): 203-209.
10. El Chaar M, Chen J, Seshan S V, et al. Effect of combination therapy with Enalapril and the, TGF-beta antagonist 1D11 in unilateral ureteral obstruction [J]. Am J Physiol Renal Physiol, 2007, 292(4):F1291-1301.
11. Yu L, Border W A, Anderson I, et al. Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect [J]. Kidney Int, 2004, 66(5):1774-1784.
12. Schnaper H W, Hayashida T, Poncelet AC. It's a Smad world: regulation of TGF-beta signaling in the kidney [J]. J Am Soc Nephrol, 2002, 13(4):887-893.
13. Fukasawa H, Yamamoto T, Togawa A, et al. Down-regulation of Smad 7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice [J]. Proc Natl Acad Sci USA, 2004, 101(23):8687-8692.
14. Inazaki K, Kanamaru Y, Kojima Y, et al. Smad 3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction [J]. Kidney Int, 2004, 66 (2):597-604.
15. Lan H Y, Mu W, Tomita N, Huang X R, et al. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model [J]. J Am Soc Nephrol, 2003, 14(6):1535-1548.
16. NING Wangbin, HU Jing, TAO Lijian, et al. Effect of losartan on the expression of TGF-β1, p-Smad 2/3 and Smad7 in remnant renal tissue of 5/6 nephrectomized rats [J]. Journal of Central South University. Medical Sciences, 2007, 32(6):1007-1012.