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[25] To a solution of Mannich base 4 (6.60 g, 24 mmol) dissolved in aqueous acetic acid (81 148 mL) was added hexamethylenetetramine (9.45 g, 67.5 mmol). The mixture was stirred at 130 °C for 4 h. After the mixture cooled to room temperature, the precipitate was collected by filtration and washed with methanol. For details, see: H. Houjou, T. Motoyama, S. Banno, I. Yoshikawa, K. Araki, J. Org. Chem., in press.
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[25] To a solution of Mannich base 4 (6.60 g, 24 mmol) dissolved in aqueous acetic acid (81 vol.-%, 148 mL) was added hexamethylenetetramine (9.45 g, 67.5 mmol). The mixture was stirred at 130 °C for 4 h. After the mixture cooled to room temperature, the precipitate was collected by filtration and washed with methanol. For details, see: H. Houjou, T. Motoyama, S. Banno, I. Yoshikawa, K. Araki, J. Org. Chem., in press.
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