Kv1.1 expression in microglia regulates production and release of proinflammatory cytokines, endothelins and nitric oxide

Neuroscience

Volumn 158, Issue 4, 2009, Pages 1500-1508

  Wu, C Y ^a   Kaur, C ^b   Sivakumar, V ^b   Lu, J ^c   Ling, E A ^b  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DSO NATIONAL LABORATORIES   (Singapore)

Author keywords

endothelins; hypoxia; Kv1.1; microglia; nitric oxide; proinflammatory cytokines

Indexed keywords

CYTOKINE; DEXAMETHASONE; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 3; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; POTASSIUM CHANNEL KV1.1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HYPOXIA; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MICROGLIA; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SERODIAGNOSIS; UPREGULATION; WESTERN BLOTTING; WISTAR RAT;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANOXIA; ANTIBODIES; BRAIN; CELL LINE, TRANSFORMED; COLORIMETRY; CYTOKINES; ENDOTHELINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; KV1.1 POTASSIUM CHANNEL; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 60149091402     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.11.043     Document Type: Article

References (28)

1. Boucsein H., Kettenmann H., and Nolte C. Electrophysiological properties of microglial cells in normal and pathologic rat brain slices. Eur J Neurosci 12 (2000) 2049-2058
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72 (1976) 248-254
3. Cao Q., Lu J., Kaur C., Sivakumar V., Li F., Cheah P.S., Dheen S.T., and Ling E.A. Expression of Notch-1 and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia 56 (2008) 1224-1237
4. Chung Y.H., Shin C.M., Kim M.J., Lee B.K., and Cha C.I. Age-related changes in the distribution of Kv1.1 and Kv1.2 channel subunits in the rat cerebellum. Brain Res 897 (2001) 193-198
5. + channels: role of the Kv1.2 α-subunit in mediating the hypoxic response. J Physiol 524 3 (2000) 783-793
6. Deng Y., Lu J., Sivakumar V., Ling E.A., and Kaur C. Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats. Brain Pathol 18 (2008) 387-400
7. Dheen S.T., Kaur C., and Ling E.A. Microglial activation and its implications in the brain diseases. Curr Med Chem 14 (2007) 1189-1197
8. Fordyce C.B., Jagasia R., and Zhu X. Microglia Kv1.3 channels contribute to their ability to kill neurons. J Neurosci 25 (2005) 7139-7149
9. Hallows J.L., and Tempel B.L. Expression of Kv1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia. J Neurosci 18 (1998) 5682-5691
10. Kaur C., Viswanathan S., Dheen S.T., and Ling E.A. Insulin-like growth factor-I and II expression and modulation in activated microglial cells by lipopolysaccharide and retinoic acid. Neuroscience 138 (2006) 1233-1244
11. + channels and the microglial respiratory burst. Am J Physiol Cell Physiol 280 (2001) C796-C806
12. Kotecha S.A., and Schlichter L.C. A Kv1.5 to Kv1.3 switches in endogenous hippocampal microglia and a role in proliferation. J Neurosci 19 (1999) 10680-10693
13. Li F., Lu J., Wu C.Y., Kaur C., Sivakumar V., Sun J., Li S., and Ling E.A. Expression of Kv1.2 in microglia and its putative roles in modulating production of proinflammatory cytokines and reactive oxygen species. J Neurochem 106 (2008) 2093-2105
14. Li J.J., Lu J., Kaur C., Sivakumar V., Wu C.-Y., and Ling E.-A. Effects of hypoxia and expression of transforming growth factor-β1 and its receptors I and II in the amoeboid microglial cells and murine BV-2 cells. Neuroscience 156 (2008) 662-672
15. Ling E.A., and Wong W.C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 7 (1993) 9-18
16. Ling E.A., Ng Y.K., Wu C.H., and Kaur C. Microglia: its development and role as a neuropathology sensor. Prog Brain Res 132 (2001) 61-79
17. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T) method. Methods 24 (2001) 402-408
18. Lyons S.A., Pastor A., Ohlemeyer C., Kann O., Wiegand F., Prass K., Knapp F., Kettenmann H., and Dirnagl U. Distinct physiologic properties of microglia and blood-borne cells in rat brain slices after permanent middle cerebral artery occlusion. J Cereb Blood Flow Metab 20 (2000) 1537-1549
19. + channel in rat microglia cultivated on Teflon. Neurosci Lett 160 (1993) 69-72
20. Prentice H.M., Milton S.L., Milton, Scheurle D., and Lutz P.L. Gene transcription of brain voltage-gated potassium channels is reversibly regulated by oxygen supply. Am J Physiol Regul Integr Comp Physiol 285 (2003) 1317-1321
21. Schilling T., Quandt F.N., Cherny V.V., Zhou W., Heinemann U., DeCoursey T.E., and Eder C. Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-ß. Am J Physiol 279 (2000) C1123-C1134
22. - channels and their involvement in proliferation of rat microglial cells. Glia 17 (1996) 225-236
23. Schmidt K., Eulita D., Veh R., Kettenmann H., and Kirchhoff F. Heterogeneous expression of voltage-gated potassium channels of the shaker family (kv1) in oligodendrocyte progenitors. Brain Res 843 (1999) 145-160
24. Walz W., and Bekar L. Ion channels in cultured microglia. Micros Res Tech 54 (2001) 26
25. Wang H., Kunkel D.D., Schwartzkroin P.A., and Tempel B.L. Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J Neurosci 14 (1994) 4588-4599
26. Wu C.Y., Kaur C., Lu J., Cao Q., Guo C.H., Zhou Y., Viswanathan S., and Ling E.A. Transient expression of endothelins in the amoeboid microglial cells in the developing rat brain. Glia 54 (2006) 513-525
27. Yang Q., Chen S.R., Li D.P., and Pan J.L. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience 149 (2007) 315-327
28. Zhou Y., Ling E.A., and Dheen S.T. Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia. J Neurochem 102 (2007) 667-666