Identification of glucoside and carboxyl-linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil

British Journal of Pharmacology

Volumn 126, Issue 5, 1999, Pages 1075-1082

  Shipkova, Maria ^a   Armstrong, Victor William ^a   Wieland, Eberhard ^a   Niedmann, Paul Dieter ^a   Schütz, Ekkehard ^a   Brenner Weiß, Gerald ^b   Voihsel, Martin ^c   Braun, Felix ^a   Oellerich, Michael ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b WFM Wasserforschung Mainz GmbH   (Germany)

^c PE Applied Biosystems   (Germany)

Author keywords

Acyl glucuronide; High performance liquid chromatography; Human microsomes; Mass spectrometry; Metabolites; Mycophenolic acid

Indexed keywords

BETA GLUCOSIDASE; BETA GLUCURONIDASE; CYTOCHROME P450; GLUCOSIDE; GLUCURONIDE; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM HYDROXIDE; URIDINE DIPHOSPHATE GLUCOSE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ARTICLE; CONJUGATE; CROSS REACTION; DRUG METABOLISM; HUMAN; HUMAN TISSUE; HYDROLYSIS; IMMUNOASSAY; LIVER METABOLISM; LIVER MICROSOME; MASS SPECTROMETRY; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

EID: 0033014930     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702399     Document Type: Article

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