Interferon-γ-mediated pathways and in vitro PBMC proliferation in HIV-infected patients

Biological Chemistry

Volumn 390, Issue 2, 2009, Pages 115-123

  Schroecksnadel, Katharina ^a,b   Winkler, Christiana ^a   Werner, Ernst R ^a   Sarcletti, Mario ^b   Romani, Nikolaus ^b   Ebner, Susanne ^b   Schennach, Harald ^b   Fuchs, Dietmar ^a   Zangerle, Robert ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

HIV; IDO; Neopterin; Peripheral blood mononuclear cells (PBMCs); Proliferation; Tryptophan degradation

Indexed keywords

ANTIRETROVIRUS AGENT; CONCANAVALIN A; CYTOKINE; DIOXYGENASE; GAMMA GLUTAMYLTRANSFERASE; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INDOLEAMINE 2,3 DIOXYGENASE; MESSENGER RNA; NEOPTERIN; PHYTOHEMAGGLUTININ; POKEWEED MITOGEN; TRYPTOPHAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGRADATION; DISEASE CONTROL; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POKEWEED; PRIORITY JOURNAL;

ADULT; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HIV INFECTIONS; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MALE; MITOGENS; MOLECULAR SEQUENCE DATA; REFERENCE STANDARDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

PHYTOLACCACEAE;

EID: 59949103960     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2009.018     Document Type: Article

References (28)

1. + T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. Blood 109, 3351-3359.
2. De Francesco, M.A., Caruso, A., Dima, F., Cantalamessa, A., Canaris, A.D., Folghera, S., Fiorentini, S., Flamminio, G., Licenziati, S., Peroni, L., et al. (1996). IFN-γ restores HIV- and non-HIV-specific cell mediated immune response in vitro and its activity is neutralized by antibodies from patients with AIDS. Scand. J. Immunol. 43, 94-100.
3. Fahey, J.L., Taylor, J.M., Manna, B., Nishanian, P., Aziz, N., Giorgi, J.V., and Detels, R. (1998). Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 12, 1581-1590.
4. Fauci, A.S. (1988). The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. Science 239, 617-622.
5. Fuchs, D., Shearer, G.M., Boswell, R.N., Clerici, M., Reibnegger, G., Werner, E.R., Zajac, R.A., and Wachter, H. (1990). Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production. Clin. Exp. Immunol. 80, 44-48.
6. Fuchs, D., Reibnegger, G., Werner-Felmayer, G., Dierich, M.P., and Wachter, H. (1991). IFN-γ to treat patients with AIDS. J. AIDS 4, 297-303.
7. Fuchs, D., Zangerle, R., Artner-Dworzak, E., Weiss, G., Fritsch, P., Tilz, G.P., Dierich, M.P., and Wachter, H. (1993). Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection. Eur. J. Haematol. 50, 90-94.
8. Hober, D., Benyoucef, S., Chehadeh, W., Chieux, V., De, L.T.X, Mouton, Y., Bocket, L., and Wattre, P. (1998). Production of interleukin-4, interferon (IFN)-γ and IFN-α in human immunodeficiency virus-1 infection: an imbalance of type 1 and type 2 cytokines may reduce the synthesis of IFN-α. Scand. J. Immunol. 48, 436-442.
9. Hofmann, B., Lindhardt, B.O., Gerstoft, J., Petersen, C.S., Platz, P., Ryder, L.P., Odum, N., Dickmeiss, E., Nielsen, P.B., Ullman, S., et al. (1987). Lymphocyte transformation response to pokeweed mitogen as a predictive marker for development of AIDS and AIDS related symptoms in homosexual men with HIV antibodies. Br. Med. J. 295, 293-296.
10. Hofmann, B., Jakobsen, K.D., Odum, N., Dickmeiss, E., Platz, P., Ryder, L.P., Pedersen, C., Mathiesen, L., Bygbjerg, I.B., Faber, V., et al. (1989). HIV-induced immunodeficiency. Relatively preserved phytohemagglutinin as opposed to decreased pokeweed mitogen responses may be due to possibly preserved responses via CD2/phytohemagglutinin pathway. J. Immunol. 142, 1874-1880.
11. + T cells and clinical status in Brazilian HIV-1-infected subjects. Rev. Inst. Med. Trop. Sao Paulo 40, 351-354.
12. Katial, R.K., Sachanandani, D., Pinney, C., and Lieberman, M.M. (1998). Cytokine production in cell culture by peripheral blood mononuclear cells from immunocompetent hosts. Clin. Diagn. Lab. Immunol. 5, 78-81.
13. Landesman, S.H. and Vieira, J. (1983). Acquired immune deficiency syndrome (AIDS): a review. Arch. Intern. Med. 143, 2307-2309.
14. Lifson, J.D., Benike, C.J., Mark, D.F., Koths, K., and Engleman, E.G. (1984). Human recombinant interleukin-2 partly reconstitutes deficient in vitro immune responses of lymphocytes from patients with AIDS. Lancet 1, 698-702.
15. Mellor, A.L., Munn, D., Chandler, P., Keskin, D., Johnson, T., Marshall, B., Jhaver, K., and Baban, B. (2003). Tryptophan catabolism and T cell responses. Adv. Exp. Med. Biol. 527, 27-35.
16. Miedema, F. (1992). Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance. Immunodef. Rev. 3, 173-193.
17. Moir, S., Malaspina, A., Pickeral, O.K., Donoghue, E.T., Vasquez, J., Miller, N.J., Krishnan, S.R., Planta, M.A., Turney, J.F., Justement, J.S., et al. (2004). Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily. J. Exp. Med. 200, 587-599.
18. Munn, D.H., Shafizadeh, E., Attwood, J.T., Bondarev, I., Pashine, A., and Mellor, A.L. (1999). Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189, 1363-1372.
19. Murray, H.W., Rubin, B.Y., Masur, H., and Roberts, R.B. (1984). Impaired production of lymphokines and immune (γ) interferon in the acquired immunodeficiency syndrome. N. Engl. J. Med. 310, 883-889.
20. Murray, H.W., Welte, K., Jacobs, J.L., Rubin, B.Y., Mertelsmann, R., and Roberts, R.B. (1985). Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome. J. Clin. Invest. 76, 1959-1964.
21. Nathan, C.F., Murray, H.W., Wiebe, M.E., and Rubin, B.Y. (1983). Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J. Exp. Med. 158, 670-689.
22. Rudy, T., Opelz, G., Gerlach, R., Daniel, V., and Schimpf, K. (1988). Correlation of in vitro immune defects with impaired γ-interferon response in human-immunodeficiency-virus-infected individuals. Vox Sang. 54, 92-95.
23. Samuel, R., Bettiker, R.L., and Suh, B. (2002). AIDS related opportunistic infections, going but not gone. Arch. Pharm. Res. 25, 215-228.
24. Schaefer, T.M., Fuller, C.L., Basu, S., Fallert, B.A., Poveda, S.L., Sanghavi, S.K., Choi, Y.K., Kirschner, D.E., Feingold, E., and Reinhart, T.A. (2006). Increased expression of interferon-inducible genes in macaque lung tissues during simian immunodeficiency virus infection. Microbes Infect. 8, 1839-1850.
25. Widner, B., Werner, E.R., Schennach, H., and Fuchs, D. (1999). An HPLC method to determine tryptophan and kynurenine in serum simultaneously. Adv. Exp. Med. Biol. 467, 827-832.
26. Winkler, C., Wirleitner, B., Schroecksnadel, K., Schennach, H., and Fuchs, D. (2004). St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro. Biol. Chem. 385, 1197-1202.
27. Wirleitner, B., Neurauter, G., Schrocksnadel, K., Frick, B., and Fuchs, D. (2003). Interferon-γ-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr.Med. Chem. 10, 1581-1591.
28. Zangerle, R., Widner, B., Quirchmair, G., Neurauter, G., Sarcletti, M., and Fuchs, D. (2002). Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection. Clin. Immunol. 104, 242-247.