IFN-γ restores HIV- and non-HIV-specific cell mediated immune response in vitro and its activity is neutralized by antibodies from patients with AIDS

Scandinavian Journal of Immunology

Volumn 43, Issue 1, 1996, Pages 94-100

  De Francesco, M A ^a   Caruso, A ^a   Dima, F ^a   Cantalamessa, A ^b   Canaris, A D ^a   Folghera, S ^a   Fiorentini, S ^a   Flamminio, G ^a   Licenziati, S ^a   Peroni, L ^a   Gao, Jing ^a   Garotta, G ^c   Turano, A ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b Ser T USSL 31   (Italy)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G; RECOMBINANT GAMMA INTERFERON; SYNTHETIC PEPTIDE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLUENZA VIRUS A; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; VIRUS ENVELOPE;

EID: 0029671039     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1996.d01-5.x     Document Type: Article

References (25)

1. Levy A. Pathogenesis of human immunodeficiency virus infection. Microb Rev 1993;57:183-289.
2. Lane H C, Masur H, Edgard LC, Whalen G et al. Abnormalities of B cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 1988;309: 453-7.
3. Rook AK, Manischewitz JD, Frederick WR et al. Deficient, HLA-restricted, cytomegalovirus-specific cytotoxic T cells and natural killer cells in patients with the acquired immunodeficiency syndrome. J Infect Dis 1985;152:627-32.
4. Shearer GM, Salahuddin SZ, Markham PD et al. Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus-III in homosexual men. J Clin Invest 1985;76:1699-704.
5. + CD25 T cell population. J Immunol 1990;444:1696-702.
6. Clerici M, Lucey DR, Berzofsky JA et al. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 1993;262:1721-29.
7. Clerici M, Shearer GM. A Th1-Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-11.
8. Clerici M, Hackim FA, Venzon DJ et al. Role of interleukin-10 (IL-10) in T helper cell dysfunction in asymptomatic individuals infected with the HIV-1. J Clin Invest 1993;91:759-62.
9. Clerici M, Stocks NI, Zajac RA et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, HIV seropositive individuals: independence of CD4 cell number and clinical staging. J Clin Invest 1989;84:1892-9.
10. Chehimi J, Starr SE, Frank J et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994;179: 1361-66.
11. Shearer GM, Clerici M. Early T-helper cell defects in HIV infection. AIDS 1991; 5: 245-53.
12. Trinchieri G. Interleukin-12 and its role in the generation of TH1 cells. Immunol Today 1993; 14: 335-8.
13. Tripp CS, Gately MK, Hakimi J et al. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. J Immunol 1994;147: 1883-6.
14. Afonso LCC, Scharton TM, Vieira LQ et al. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994;263:235-7.
15. Caruso A, Foresti I, Gribaudo G et al. Anti-interferon-γ antibodies in sera from HIV infected patients. J Biol Reg Homeost Agents 3:8-12.
16. + lymphocytes of AIDS patients synthesize increased amounts of IFN-γ. J Acquir Immune Def Syndr, in press.
17. Cease KB, Margalit H, Cornette JL et al. Helper T cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide. Proc Natl Acad Sci U.S.A. 1987;84:4249-53.
18. Clerici M, Stocks NI, Zajac RA et al. Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals. Nature 1989;339: 383-5.
19. Dobeli H, Gentz R, Jucker W et al. Role of the carboxy-terminal sequence on the biological activity of human immune interferon (IFN-γ). J Biotechnol 1988;7:199-212.
20. Centers for Diseases Control. Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescent and adult. MMWR 1993;41:1-19.
21. Viani E, Flamminio G, Caruso A et al. Purification of natural human IFN-γ antibodies. Immunol Lett 1991; 30: 53-8.
22. Novelli F, Giovarelli M, Reber-Liske R et al. Blockade of physiologically secreted IFN-γ inhibits human T lymphocytes and natural killer cell activation. J Immunol 1991;147: 1445-52.
23. Caruso A, Bonfanti C, Colombrita D et al. Natural antibodies to IFN-γ in man and their increase during viral infection. J Immunol 1990;144: 685-9.
24. Bonfanti C, Caruso A, Bakhiet M et al. Increased levels of antibodies to IFN-γ in human and experimental african trypanosomiasis. Scand J Immunol 1994;41:49-52.
25. Turano A, Balsari A, Viani E et al. Natural human antibodies to γ interferon interfere with the immunomodulating activity of the lymphokine. Proc Natl Acad Sci USA 1992;89: 4447-51.