Biosynthesis, processing, and secretion of glial cell line-derived neurotrophic factor in astroglial cells

Molecular and Cellular Biochemistry

Volumn 323, Issue 1-2, 2009, Pages 1-7

  Oh hashi, Kentaro ^a   Ito, Masatoshi ^a   Tanaka, Tatsuhide ^a   Hirata, Yoko ^a   Kiuchi, Kazutoshi ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Furin; Glial cell line derived neurotrophic factor (GDNF); Processing; proGDNF

Indexed keywords

FURIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHORESIS; EXPRESSION VECTOR; GENE DELETION; GENE OVEREXPRESSION; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; ASTROCYTES; CELLS, CULTURED; CULTURE MEDIA; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEURONS; PROTEIN PRECURSORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 59949103816     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9958-3     Document Type: Article

References (30)

1. Lin LF, Doherty DH, Lile JD et al (1993) GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132. doi: 10.1126/science.8493557
2. Poulsen KT, Armanini MP, Klein RD et al (1994) TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13:1245-1252. doi: 10.1016/0896-6273(94)90062-0
3. Choi-Lundberg DL, Bohn MC (1995) Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res Dev Brain Res 85:80-88. doi: 10.1016/0165-3806(94)00197-8
4. Suvanto P, Hiltunen JO, Arumae U et al (1996) Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. Eur J Neurosci 8:816-822. doi: 10.1111/ j.1460-9568.1996.tb01267.x
5. Moore MW, Klein RD, Farinas I et al (1996) Rosenthal, renal and neuronal abnormalities in mice lacking GDNF. Nature 382:76-79. doi: 10.1038/ 382076a0
6. Pichel JG, Shen L, Sheng HZ et al (2000) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382:73-76. doi: 10.1038/382073a0
7. Satake K, Matsuyama Y, Kamiya M et al (2000) Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury. Neuroreport 11:3877-3881. doi: 10.1097/00001756-200011270-00054
8. Ikeda T, Koo H, Xia YX (2002) Bimodal upregulation of glial cell line-derived neurotrophic factor (GDNF) in the neonatal rat brain following ischemic/hypoxic injury. Int J Dev Neurosci 20:555-562. doi: 10.1016/S0736-5748(02)00082-5
9. Eslamboli A, Georgievska B, Ridley RM et al (2005) Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. J Neurosci 25:769-777. doi: 10.1523/JNEUROSCI.4421-04.2005
10. Eigenbrot C, Gerber N (1997) X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat Struct Biol 4:435-438. doi: 10.1038/nsb0697-435
11. Mouri A, Nomoto H, Furukawa S (2007) Processing of nerve growth factor: the role of basic amino acid clusters in the pro-region. Biochem Biophys Res Commun 353:1056-1062. doi: 10.1016/j.bbrc.2006.12.136
12. Nomoto H, Takaiwa M, Mouri A, Furukawa S (2007) Pro-region of neurotrophins determines the processing efficiency. Biochem Biophys Res Commun 356:919-924. doi: 10.1016/j.bbrc.2007.03.059
13. Lim KC, Tyler CM, Lim ST et al (2007) Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun 361:599-604. doi: 10.1016/j.bbrc.2007.07.039
14. Tanaka T, Oh-hashi K, Ito M et al (2008) Identification of a novel GDNF mRNA induced by LPS in immune cell lines. Neurosci Res 61:11-17. doi: 10.1016/j.neures.2008.01.004
15. Alfano I, Vora P, Mummery RS et al (2007) The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding. Biochem J 404:131-140. doi: 10.1042/BJ20061747
16. Immonen T, Alakuijala A, Hytönen M et al (2008) A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus. Exp Neurol 210:793-796. doi: 10.1016/j.expneurol.2007.12.018
17. Scamuffa N, Calvo F, Chrétien M et al (2006) Proprotein convertases: Lessons from knockouts. FASEB J 20:1954-1963. doi: 10.1096/ fj.05-5491rev
18. Bruno MA, Cuello AC (2006) Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. Proc Natl Acad Sci USA 103:6735-6740. doi: 10.1073/pnas.0510645103
19. Mowla SJ, Farhadi HF, Pareek S et al (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276:12660-12666. doi: 10.1074/ jbc.M008104200
20. Kinameri E, Matsuoka I (2003) Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells. Brain Res Mol Brain Res 117:221-227. doi: 10.1016/S0169-328X(03)00326-7
21. Oh-hashi K, Kaneyama M, Hirata Y, Kiuchi K (2006) ER calcium discharge stimulates GDNF gene expression through MAPK-dependent and -independent pathways in rat C6 glioblastoma cells. Neurosci Lett 405:100-105. doi: 10.1016/j.neulet.2006.06.027
22. Ribeiro CM, McKay RR, Hosoki E et al (2000) Effects of elevated cytoplasmic calcium and protein kinase C on endoplasmic reticulum structure and function in HEK293 cells. Cell Calcium 27:175-185. doi: 10.1054/ceca.2000.0108
23. Shiraishi H, Okamoto H, Yoshimura A, Yoshida H (2006) ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. J Cell Sci 119:3958-3966. doi: 10.1242/ jcs.03160
24. Nielsen M, Madsen P, Christensen EI et al (2001) The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J 20:2180-2190. doi: 10.1093/ emboj/20.9.2180
25. Nykjaer A, Lee R, Teng KK et al (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427:843-848. doi: 10.1038/ nature02319
26. Teng HK, Teng KK, Lee R et al (2005) ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25:5455-5463. doi: 10.1523/JNEUROSCI.5123-04.2005
27. Chen ZY, Ieraci A, Teng H et al (2005) Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci 25:6156-6166. doi: 10.1523/JNEUROSCI.1017-05.2005
28. Lee R, Kermani P, Teng KK, Hempstead BL (2001) Regulation of cell survival by secreted proneurotrophins. Science 294:1945-1948. doi: 10.1126/science.1065057
29. Fahnestock M, Michalski B, Xu B, Coughlin MD (2001) The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol Cell Neurosci 18:210-220. doi: 10.1006/mcne.2001.1016
30. Harrington AW, Leiner B, Blechschmitt C et al (2004) Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proc Natl Acad Sci USA 101:6226-6230. doi: 10.1073/pnas.0305755101