Neoplastic Transformation Induced by Carbon Ions

International Journal of Radiation Oncology Biology Physics

Volumn 73, Issue 3, 2009, Pages 861-868

  Bettega, Daniela ^a   Calzolari, Paola ^a   Hessel, Petra ^b   Stucchi, Claudio G ^c   Weyrather, Wilma K ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b Biophysik   (Germany)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Carbon ions; CGL1 cells; Clonogenic survival; Neoplastic transformation; Relative biologic effectiveness

Indexed keywords

CELL CULTURE; IONS; PHOTONS;

CARBON IONS; CGL1 CELLS; CLONOGENIC SURVIVAL; NEOPLASTIC TRANSFORMATION; RELATIVE BIOLOGIC EFFECTIVENESS;

FOURIER TRANSFORMS;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL SURVIVAL; CLONOGENESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; ION THERAPY; PHOTON THERAPY; PRIORITY JOURNAL; RADIATION DOSE; TUMOR VOLUME;

CARBON; CARBON RADIOISOTOPES; CELL NUCLEUS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; FIBROBLASTS; HELA CELLS; HUMANS; HYBRID CELLS; LINEAR ENERGY TRANSFER; PHOTONS; POISSON DISTRIBUTION; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 59849129325     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.07.067     Document Type: Article

References (47)

1. Schulz-Ertner D., Nikoghosyan A., Thilmann C., et al. Results of carbon ion radiotherapy in 152 patients. Int J Radiat Oncol Biol Phys 58 (2004) 631-640
2. Schulz-Ertner D., Karger C.P., Feuerhake A., et al. Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 68 (2007) 449-457
3. Hawkins M.M. Second primary tumors following radiotherapy for childhood cancer. Int J Radiat Oncol Biol Phys 19 (1990) 1297-1301
4. Heyn R., Haeberlen V., Newton W.A., et al. Second malignant neoplasm in children treated for rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee. Clin Oncol 11 (1993) 262-270
5. Sznajder L., Abrahams C., Parry D., et al. Multiple schwannomas and meningiomas associated with irradiation in childhood. Arch Intern Med 156 (1996) 1873-1878
6. Reznikoff C.A., Brankow D.W., and Heidelberger C. Establishment and characterization of a clone line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res 33 (1973) 3231-3238
7. Hei T.K., Komatsu K., Hall E.J., et al. Oncogenic transformation by charged particles of defined LET. Carcinogenesis 9 (1988) 747-750
8. Miller R.C., and Hall E.J. Oncogenic transformation of C3H 10T1/2 cells by acute and protracted exposures to monoenergetic neutrons. Radiat Res 128 Suppl 1 (1991) S60-S64
9. Balcer-Kubiczek E.K., Harrison G.H., and Hei T.K. Neutron dose-rate experiments at the AFRRI Nuclear Reactor. Radiat Res 128 Suppl 1 (1991) S65-S70
10. Bettega D., Calzolari P., Pollara P., et al. In vitro cell transformations induced by 31 MeV protons. Radiat Res 104 (1985) 178-181
11. Bettega D., Calzolari P., Noris Chiorda G., et al. Transformation of C3H 10T1/2 cells with 4.3 MeV α particles at low doses: Effects of single and fractionated doses. Radiat Res 131 (1992) 66-71
12. Miller R.C., Marino A., Brenner D.J., et al. The biological effectiveness of radon-progeny alpha particles. II. Oncogenic transformation as a function of linear energy transfer alpha particles. Radiat Res 142 (1995) 54-60
13. Yang T.C.-H., Craise L.M., Mei M.-T., et al. Neoplastic cell transformation by heavy charged particles. Radiat Res 104 Suppl 8 (1985) S177-S187
14. Miller R.C., Marino S.A., Napoli J., et al. Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons. Int J Radiat Biol 76 (2000) 327-333
15. International Commission on Radiation Units and Meaurements. The Quality Factor in Radiation Protection. Report 40. International Commission on Radiation Units and Meaurements. Washington, DC; 1986.
16. International Commission on Radiation Protection. 1990 Recommendations of the International Commission on Radiation Protection. Publication 60. Annals of the ICRP 21 (1991), Pergamon, London
17. Stanbridge E.J., Der C.J., Doersen C.J., et al. Human cell hybrids analysis of transformation and tumorigenicity. Science 215 (1982) 252-259
18. Redpath J.L., Sun C., Colman M., et al. Neoplastic transformation of human hybrid cells by radiation: A quantitative assay. Radiat Res 110 (1987) 468-472
19. Mendonca M.S., Antoniono R.J., Latham K.M., et al. Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of γ-irradiated HeLa x fibroblast cell hybrids. Cancer Res 51 (1991) 4455-4462
20. Mendonca M.S., Antoniono R.J., Sun C., et al. A simplified and rapid staining method for the HeLa x skin fibroblast human hybrid cell neoplastic transformation assay. Radiat Res 131 (1992) 345-350
21. Bettega D., Calzolari P., Piazzolla A., et al. Alpha-particle-induced neoplastic transformation in synchronized hybrid cells of HeLa and human skin fibroblasts. Int J Radiat Biol 72 (1997) 523-529
22. Weyrather W.K., Ritter S., Scholz M., et al. RBE for carbon track-segment irradiation in cell lines of differing repair capacity. Int J Radiat Biol 75 (1999) 1357-1364
23. Sun C., Redpath J.L., Colman M., et al. Further studies on the radiation-induced expression of a tumor-specific antigen in human cell hybrids. Radiat Res 114 (1988) 84-93
24. Han A., and Elkind M.M. Transformation of mouse C3H10T1/2 cells by single and fractionated doses of X-rays and fission-spectrum neutrons. Cancer Res 39 (1979) 123-130
25. Kraft G., Daues H.W., Fischer B., et al. Irradiation chamber and sample changer for biological samples. Nucl Instrum Methods 168 (1980) 175-179
26. Kraft-Weyrather W., Kraft G., Ritter S., et al. The preparation of biological targets for heavy-ion experiments up to 20 MeV/u. Nucl Instrum Methods 282 (1989) 22-27
27. Haberer T., Becher W., Schardt D., et al. Magnetic scanning system for heavy ion therapy. Nucl Instrum Methods 330 (1993) 296-305
28. Schwab T. Transport von Schwerionen durch Materie innerhalb ionenoptischer Systeme. Ph.D. thesis, Universitát Giessen. GSI Report 1991;91-10.
29. Bettega D., Calzolari P., Doglia B., et al. Cell thickness measurements by confocal fluorescence microscopy on C3H10T1/2 and V79 cells. Int J Radiat Biol 74 (1998) 397-403
30. Jaekel O., Hartmann G.H., Karger C.P., et al. A calibration procedure for beam monitors in a scanned beam of heavy charged particles. Med Phys 31 (2004) 1009-1013
31. Jäkel O., Hartmann G., Karger C., et al. Quality assurance for a treatment planning system in scanned ion beam therapy. Med Phys 27 (2000) 1588-1600
32. Colman M., Bhatt S., Candelaria M., et al. A comparison of the radiation sensitivities of non-tumorigenic and tumorigenic human hybrid cell lines. Int J Radiat Biol 53 (1988) 609-616
33. M for various end points. Radiat Res 157 (2002) 99-105
34. Frankenberg-Schwager M., Spieren S., Pralle E., et al. Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays. Radiat Prot Dosimetry 122 (2006) 180-184
35. Elmore E., Lao X.-Y., Ko M., et al. Neoplastic transformation in vitro induced by low doses of 232 MeV protons. Int J Radiat Biol 81 (2005) 291-297
36. 1 phase are not hypersensitive cell cycle phases for neoplastic transformation of hela x skin fibroblast human hybrid cells induced by fission-spectrum neutrons. Radiat Res 141 (1995) 37-43
37. Han R.C., Suzuki H., Suzuki F., et al. Neoplastic transformation of hamster embryo cells by heavy ions. Adv Space Res 22 (1998) 1725-1732
38. Borek C., Hall E.J., and Rossi H.H. Malignant transformation in cultured hamster embryo cells produced by X-rays, 430-keV monoenergetic neutrons, and heavy ions. Cancer Research 38 (1978) 2997-3005
39. Suzuki M., Watanabe M., Suzuki K., et al. Neoplastic cell transformation by heavy ions. Radiat Res 120 (1989) 468-476
40. Martin S., Miller R.C., Geard C.R., et al. The biological effectiveness of radon-progeny alpha particles. IV. Morphological transformation of Syrian hamster embryo cells at low doses. Radiat Res 142 (1995) 70-77
41. Hall E.J. Failla Memorial Lecture; From beans to genes-back to the future. Radiat Res 129 (1992) 235-249
42. Trott D.A., Cuthbert A.P., Overell R.W., et al. Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens. Carcinogenesis 16 (1995) 193-204
43. Mendonca M.S., Howard K., Fasching C.L., et al. Loss of suppressor loci on chromosomes 11 and 14 may be required for radiation-induced neoplastic transformation on HeLa x fibroblast human cell hybrids. Radiat Res 149 (1998) 246-255
44. Alpen E.L., Powers-Risius P., Curtis S.B., et al. Fluence-based relative biological effectiveness for charged particles carcinogenesis in mouse Harderian gland. Adv Space Res 14 (1994) 573-581
45. Imaoka T., Nishimura M., Kakinuma S., et al. High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-Ras and TP53 mutations. Int J Radiat Oncol Biol Phys 69 (2007) 194-203
46. Hall E.J., and Wuu C.-S. Radiation-induced second cancers: The impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56 (2003) 83-88
47. Hall E.J. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 65 (2006) 1-7