Neoplastic transformation in vitro induced by low doses of 232 MeV protons

International Journal of Radiation Biology

Volumn 81, Issue 4, 2005, Pages 291-297

  Elmore, E ^a   Lao, X Y ^a   Ko, M ^a   Rightnar, S ^b   Nelson, G ^b   Redpath, J L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

High energy protons; Neoplastic transformation

Indexed keywords

PROTON; VANADIUM DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HELA CELL; HUMAN; HUMAN CELL; HYBRID CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTON RADIATION; RADIATION DOSE; SKIN FIBROBLAST;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

CELL TRANSFORMATION, NEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, RADIATION; HELA CELLS; HUMANS; LINEAR ENERGY TRANSFER; PROTONS;

EID: 22244492607     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000500140324     Document Type: Article

References (39)

1. Alpen EL. 1998. In Radiation Biophysics. New York: Academic Press, p. 385.
2. Azzam EI, De Toledo SM, Raaphorst GP, Mitchel REJ. 1996. Low dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiation Research 146: 369-373.
3. Balcer-Kubiczek EK, Harrison GH, Thompson BW. 1987. Repair time for oncogenic transformation in C3H 10T1/2 cells subjected to protracted X-irradiation. International Journal of Radiation Biology 51: 219-226.
4. Bettega D, Calozari P, Noris Chiorda G, Tallone-Lombardi L. 1992. Transformation of C3H 10T1/2 cells with 4. 3 MeV α-particles at low doses: effect of single and fractionated doses. Radiation Research 131: 66-71.
5. Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M. 2003. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know. Proceedings of the National Academy of Sciences, USA 100: 13761-13766.
6. 3H β particles in normal human fibroblasts. Radiation Research 158: 181-186.
7. Cucinotta FA, Wu H, Shavers MR, George K. 2003. Radiation dosimetry and biophysical models of space radiation effects. Gravitational and Space Biology Bulletin 16: 11-18.
8. Feinendegen LE. 2003. Relative implications of protective responses versus damage induction at low dose and low-dose-rate exposures, using the microdose approach. Radiation Protection and Dosimetry 104: 337-346.
9. Fry RJM, Powers-Risius P, Alpen EL, Ainsworth EJ. 1985. High LET radiation carcinogenesis. Radiation Research 104: S188-S195.
10. Han A, Elkind MM. 1979. Transformation of mouse C3H 10T1/2 cells by single and fractionated doses of X-rays and fission-spectrum neutrons. Cancer Research 39: 2123-130.
11. Hill CK, Han A, Elkind MM. 1984. Fission-spectrum neutrons at low dose rate enhance neoplastic transformation in the linear, low dose region (0-10 cGy). International Journal of Radiation Biology 46: 11-15.
12. Iyer R, Lehnert BE. 2002. Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutation Research 503: 1-9.
13. Ko S, Liao, X-Y, Molloi S, Elmore E, Redpath JL. 2004. Neoplastic transformation in vitro following exposure to low doses of mammographic energy X-rays: quantitative and mechanistic aspects. Radiation Research 162: 646-654.
14. Little JB. 1989. The relevance of cell transformation to carcinogenesis in vivo. In: Baverstock KF, Strather JW, editors. Low dose radiation: biological bases of risk assessment. London: Taylor & Francis, p. 396-413.
15. Mendonca MS, Antoniono RJ, Latham KM, Stanbridge EJ, Redpath JL. 1991. Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of gamma-irradiated HeLa × fibroblast cell hybrids. Cancer Research 51: 4455-4462.
16. Mendonca MS, Antoniono RJ, Sun C, Redpath JL. 1992. A simplified and rapid staining method for the HeLa × skin fibroblast human hybrid cell neoplastic transformation assay. Radiation Research 131: 345-350.
17. Mitchell SA, Marino SA, Brenner DJ, Hall EJ. 2004a. Bystander effect and adaptive response in C3H 10T1/2 cells. International Journal of Radiation Biology 80: 465-472.
18. Mitchell SA, Randers-Pehrson G, Brenner DJ, Hall EJ. 2004b. The bystander response in C3H 10T1/2 cells: the influence of cell-to-cell contact. Radiation Research 161: 397-401.
19. Morgan WF. 2003. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiation Research 159: 567-580.
20. Mothersill C, Seymour C. 2003. Radiation-induced bystander effects carcinogenesis and models. Oncogene 22: 7028-7033.
21. National Council on Radiologic Protection and Measurements. 2000. Recommendations of dose limits for low earth orbit. Report 132. Bethesda, MD: NCRP.
22. Pant MC, Liao X-Y, Lu Q, Molloi S, Elmore E, Redpath JL. 2003. Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation. Carcinogenesis 24: 1961-1965.
23. Preston D, Shimizu Y, Pierce DA, Suyama A, Mabuchi K. 2003. Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997. Radiation Research 160: 381-407.
24. Radivoyevitch T, Kozubeck S, Sachs RK. 2002. The risk of chronic myeloid leukemia: can the dose - response curve be U-shaped? Radiation Research 157: 106-109.
25. Redpath JL, Antoniono RJ. 1998. Induction of an adaptive response against low dose gamma radiation. Radiation Research 149: 517-520.
26. Redpath JL, Liang D, Taylor TH, Christie C, Elmore E. 2001. The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation. Radiation Research 156: 700-707.
27. Redpath JL, Lu Q, Liao X, Molloi S, Elmore E. 2003a. Low doses of diagnostic energy X-rays protect against neoplastic transformation in vitro. International Journal of Radiation Biology 79: 235-240.
28. Redpath JL, Short SC, Woodcock M, Johnston PJ. 2003b. Low dose reduction in transformation frequency compared to unirradiated controls: the role of hyper-radiosensitivity to cell kill. Radiation Research 159: 433-436.
29. Russell WC, Newman C, Williamson DH. 1975. A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses. Nature 253: 461-472.
30. Rust DM. 1992. Solar flares: an overview. Advances in Space Research 12: 289-301.
31. Sawant SG, Randers-Pehrson G, Geard CR, Brenner DJ, Hall EJ. 2001a. The bystander effect in radiation oncogenesis: I. Transformation of C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiation Research 155: 397-401.
32. Sawant SG, Randers-Pehrson G, Metting NF, Hall EJ. 2001b. Adaptive response and the bystander effect induced by radiation in C3H 10T1/2 cells in culture. Radiation Research 156: 177-180.
33. Scott BR, Walker DM, Tesfaigi Y, Schollnberger H, Walker V. 2003. Mechanistic basis for non-linear dose - response relationships for low-dose radiation-induced stochastic effects. Nonlinearity in Biology, Toxicology and Medicine 1: 93-122.
34. Stanbridge EJ, Flandemeyer RR, Daniels DW, Nelson-Rees WA. 1981. Specific chromosome loss associated with expression of tumorigenicity in human-cell hybrids. Somatic Cell Genetics 7: 699-712.
35. Sun C, Redpath JL, Colman M, Stanbridge EJ. 1988. Further studies of the radiation-induced expression of a tumor-associated antigen in human cell hybrids. Radiation Research 114: 84-93.
36. Ullrich RL. 1984. Tumor induction in BALB/c female mice after fractionated or protracted exposures to fission-spectrum neutrons. Radiation Research 97: 587-597.
37. Ullrich RL, Storer JB. 1979. Influence of γ irradiation on the development of neoplastic disease in mice. III. Dose-rate effects. Radiation Research 80: 325-342.
38. Wolff S. 1998. The adaptive response in radiobiology: evolving insights and implications. Environmental Health Perspectives 106(Suppl. 1): 277-283.
39. Yang TC. 1999. Proton radiobiology and uncertainties. Radiation Measurements 30: 383-392.