Differentiating nicotine- versus schizophrenia-associated decreases of the α7 nicotinic acetylcholine receptor transcript, CHRFAM7A, in peripheral blood lymphocytes

Journal of Neural Transmission

Volumn 116, Issue 2, 2009, Pages 213-220

  Severance, Emily G ^a   Dickerson, Faith B ^b   Stallings, Cassie R ^b   Origoni, Andrea E ^b   Sullens, Anne ^b   Monson, Eric T ^c   Yolken, Robert H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHEPPARD PRATT HEALTH SYSTEM   (United States)

^c UTAH STATE UNIVERSITY   (United States)

Author keywords

Alpha7 nicotinic receptor; Biomarker; Inflammation; Nicotinic acetylcholine receptor; Peripheral blood monocytes; Smoking

Indexed keywords

BUNGAROTOXIN RECEPTOR; C REACTIVE PROTEIN; COTININE; NICOTINE; PROTEIN CHRFAM7A; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SCHIZOPHRENIA; SMOKING; TRANSCRIPTION INITIATION;

C-REACTIVE PROTEIN; COTININE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LYMPHOCYTES; NICOTINE; PROTEIN ISOFORMS; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCHIZOPHRENIA; SMOKING; TRANSCRIPTION, GENETIC;

EID: 59849113167     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-008-0164-y     Document Type: Article

References (52)

1. Becton-Dickinson BD (2003) Vacutainer CPT package insert. Becton, Dickinson and Company, New Jersey
2. CR Breese MJ Lee CE Adams 2000 Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia Neuropsychopharmacology 23 351 364
3. N Breslau EO Johnson 2000 Predicting smoking cessation and major depression in nicotine-dependent smokers Am J Public Health 90 1122 1127
4. DE Casey 2005 Metabolic issues and cardiovascular disease in patients with psychiatric disorders Am J Med 118 15S 22S
5. CDC 2005 Cigarette smoking among adults-United States, 2004 MMWR Morb Mortal Wkly Rep 54 1121 1124
6. L Chafetz MC White G Collins-Bride 2005 The poor general health of the severely mentally ill: impact of schizophrenic diagnosis Community Ment Health J 41 169 184
7. GW Dalack DJ Healy JH Meador-Woodruff 1998 Nicotine dependence and schizophrenia: clinical phenomenon and laboratory findings Am J Psychiatry 155 1490 1501
8. R de Beaurepaire M Lukasiewicz P Beauverie 2007 Comparison of self-reports and biological measures for alcohol, tobacco, and illicit drugs consumption in psychiatric inpatients Eur Psychiatry 22 540 548
9. V De Luca O Likhodi HH Van Tol 2006 Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia Acta Psychiatr Scand 114 211 215
10. EL Dempster T Toulopoulou C McDonald 2006 Episodic memory performance predicted by the 2 bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene Am J Psychiatry 163 1832 1834
11. F Dickerson C Stallings A Origoni 2007 C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia Schizophr Res 93 261 265
12. T Dietrich RI Garcia P de Pablo 2007 The effects of cigarette smoking on C-reactive protein concentrations in men and women and its modification by exogenous oral hormones in women Eur J Cardiovasc Prev Rehabil 14 694 700
13. X Fan C Pristach EY Liu 2007 Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia Psychiatry Res 149 267 271
14. R Filik A Sipos PG Kehoe 2006 The cardiovascular and respiratory health of people with schizophrenia Acta Psychiatr Scand 113 298 305
15. First MB, Spitzer RL, Gibbon M, Williams JBW (1996) Structured clinical interview for DSM-IV axis I disorders, clinician version (SCID-CV). American Psychiatric Press, Washington DC
16. MA Fisher GW Taylor BJ Shelton 2007 Sociodemographic characteristics and diabetes predict invalid self-reported non-smoking in a population-based study of US adults BMC Public Health 7 33
17. RH Flomen DA Collier S Osborne 2006 Association study of CHRFAM7A copy number and 2 bp deletion polymorphisms with schizophrenia and bipolar affective disorder Am J Med Genet B Neuropsychiatr Genet 141B 571 575
18. R Freedman M Hall LE Adler 1995 Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia Biol Psychiatry 38 22 33
19. R Freedman H Coon M Myles-Worsley 1997 Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus Proc Natl Acad Sci USA 94 587 592
20. J Gault M Robinson R Berger 1998 Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) Genomics 52 173 185
21. J Gault J Hopkins R Berger 2003 Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects Am J Med Genet B Neuropsychiatr Genet 123B 39 49
22. TP George JC Vessicchio A Termine 2003
23. DC Goff DC Henderson E Amico 1992 Cigarette smoking in schizophrenia: relationship to psychopathology and medication side effects Am J Psychiatry 149 1189 1194
24. DC Goff C Cather AE Evins 2005 Medical morbidity and mortality in schizophrenia: guidelines for psychiatrists J Clin Psychiatry 66 183 194
25. ZZ Guan X Zhang K Blennow 1999 Decreased protein level of nicotinic receptor alpha7 subunit in the frontal cortex from schizophrenic brain NeuroReport 10 1779 1782
26. TF Heatherton LT Kozlowski RC Frecker 1991 The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire Br J Addict 86 1119 1127
27. IW Jones A Westmacott E Chan 2006 Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes J Mol Neurosci 30 83 84
28. K Kawashima T Fujii 2000 Extraneuronal cholinergic system in lymphocytes Pharmacol Ther 86 29 48
29. 2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T cell line Life Sci 72 2155 2158
30. V Kumari P Postma 2005 Nicotine use in schizophrenia: the self medication hypotheses Neurosci Biobehav Rev 29 1021 1034
31. IC Lai CJ Hong SJ Tsai 2001 Association study of a nicotinic receptor variant with schizophrenic disorders Neuropsychobiology 43 15 18
32. S Leonard C Adams CR Breese 1994 Schizophrenia and nicotinic receptors Harv Rev Psychiatry 2 179 192
33. S Leonard J Gault J Hopkins 2002 Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia Arch Gen Psychiatry 59 1085 1096
34. CM Martin-Ruiz VH Haroutunian P Long 2003 Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia Biol Psychiatry 54 1222 1233
35. A Marutle X Zhang J Court 2001 Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia J Chem Neuroanat 22 115 126
36. SV Mathew AJ Law BK Lipska 2007 {alpha}7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in Neuregulin 1 Hum Mol Genet 16 2921 2932
37. RG McCreadie 2002 Use of drugs, alcohol and tobacco by people with schizophrenia: case-control study Br J Psychiatry 181 321 325
38. DS McGehee LW Role 1995 Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons Annu Rev Physiol 57 521 546
39. K Pärna M Rahu LD Youngman 2005 Self-reported and serum cotinine-validated smoking in pregnant women in Estonia Matern Child Health J 9 385 392
40. O Perl T Ilani RD Strous 2003 The alpha7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes FASEB J 17 1948 1950
41. O Perl RD Strous A Dranikov 2006 Low levels of alpha7-nicotinic acetylcholine receptor mRNA on peripheral blood lymphocytes in schizophrenia and its association with illness severity Neuropsychobiology 53 88 93
42. G Raux F Bonnet-Brilhault S Louchart 2002 The -2 bp deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit Mol Psychiatry 7 1006 1011
43. 2+ response J Immunol 179 2889 2898
44. B Riley M Williamson D Collier 2002 A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14 Genomics 79 197 209
45. KZ Sato T Fujii Y Watanabe 1999 Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines Neurosci Lett 266 17 20
46. EG Severance RH Yolken 2008 Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia Genes Brain Behav 7 37 45
47. MV Skok EN Kalashnik LN Koval 2003 Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines Mol Pharmacol 64 885 889
48. MV Skok R Grailhe JP Changeux 2005 Nicotinic receptors regulate B lymphocyte activation and immune response Eur J Pharmacol 517 246 251
49. HK Takahashi H Iwagaki R Hamano 2007 The immunosuppressive effects of nicotine during human mixed lymphocyte reaction Eur J Pharmacol 559 69 74
50. D Twardella J Küpper-Nybelen D Rothenbacher 2004 Short-term benefit of smoking cessation in patients with coronary heart disease: estimates based on self-reported smoking data and serum cotinine measurements Eur Heart J 25 2101 2108
51. Y Villiger I Szanto S Jaconi 2002 Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes J Neuroimmunol 126 86 98
52. DM Ziedonis JM Williams 2003 Management of smoking in people with psychiatric disorders Curr Opin Psychiatry 16 305 315